Appraising histone H4 lysine 5 lactylation as a novel biomarker in breast cancer.

Background Posttranslational modifications of histone lysine (K) have integral connections with cell metabolism, and participate in the carcinogenesis of various cancers. This study focuses on evaluating the expression of histone H4 lys 5 lactylation (H4K5lac) and its clinical role in breast cancer (BC). Methods During this research, immunohistochemistry (IHC) and immunoblotting, utilizing a specific primary anti-L-lactyl-histone H4 (Lys 5) rabbit monoclonal antibody, were employed to assess H4K5lac expression in BC tissue chips.

The association between obstructive sleep apnea and nocturnal enuresis in children: current advances and research trends.

Background: Obstructive sleep apnea (OSA) and nocturnal enuresis (NE) represent two clinically prevalent pediatric disorders that frequently present as comorbidities. OSA, characterized by recurrent upper airway collapse during sleep, and NE, defined as involuntary voiding during sleep, collectively contribute to psychosocial distress in children. Emerging evidence suggests that OSA in children can cause NE through multiple mechanisms, though the pathophysiological interplay involving altered arousal thresholds and hormonal dysregulation remains incompletely elucidated.

Effects of Low Concentrations of Hypochloric Acid on the Agricultural Soil Properties.

The oxidant (e.g., hypochlorous acid, HClO) has been widely used to remediate contaminated sites.

Chinese Association of Ultrasound in Medicine and Engineering, Superficial Organs and Peripheral Vessels Committee Expert Consensus on Selected Common Clinical Issues in Parathyroid Ultrasound (2024 Edition).

Parathyroid ultrasound is widely used in clinical practice and plays a crucial role in the diagnosis and treatment of parathyroid diseases. Nevertheless, ultrasound physicians frequently encounter a number of challenges and doubts in their professional practice. For this reason, Superficial Organs and Peripheral Vessels Committee of Chinese Association of Ultrasound in Medicine and Engineering has formulated the expert consensus on certain common clinical problems of parathyroid ultrasound based on the current research progress and clinical experience, in order to guide the clinical practice.

Farnesoid X receptor regulates CYP1A1 and CYP1B1 and estradiol metabolism in mouse and human cell lines.

Human CYP1A1 and CYP1B1 are two important enzymes for the hydroxylation of estrogens. In this study, we aimed to investigate the potential role for FXR receptor in the regulation of CYP1A1 and CYP1B1 expressions and activities. First, pharmacokinetic analysis was conducted in male wild-type and Fxr mice after intraperitoneal dosing of exogenous estradiol.

The impact of digital transformation on open innovation performance: The intermediary role of digital innovation dynamic capability.

In the context of digital economy, both the process and boundaries of open innovation performance are changing, and digital transformation has become an important factor for enterprises to realize open innovation performance in a complex and changing environment. This study based on the dynamic capability theory, etc. to explore how digital transformation drives the open innovation performance of enterprises and analyze its impact effects as well as the internal mechanism of action.

Tuberculosis incidence, deaths and disability-adjusted life years in children and adolescence, 1990-2021: Results from the Global Burden of Disease Study 2021.

Background: For a long time, eliminating tuberculosis (TB) has been an enormous challenge in global health. We aim to use the 2021 Global Burden of Disease Study (GBD 2021) to systematically analyze the TB burden in children and adolescents.

Methods: We used the 2021 GBD to retrieve TB incidence, mortality, and disability-adjusted life years (DALYs) data among people aged 0 to19 years in 204 countries and regions between 1990 to 2021.

Measurement of Mitochondrial Membrane Potential In Vivo using a Genetically Encoded Voltage Indicator.

Mitochondrial membrane potential (MMP, ΔΨm) is critical for mitochondrial functions, including ATP synthesis, ion transport, reactive oxygen species (ROS) generation, and the import of proteins encoded by the nucleus. Existing methods for measuring ΔΨm typically use lipophilic cation dyes, such as Rhodamine 800 and tetramethylrhodamine methyl ester (TMRM), but these are limited by low specificity and are not well-suited for in vivo applications. To address these limitations, we have developed a novel protocol utilizing genetically encoded voltage indicators (GEVIs).

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis.

Background: We investigated the corneal biomechanical properties and their genotype-phenotype correlation correlations in patients with Marfan syndrome (MFS) and ectopia lentis (EL).

Methods: Patients with MFS with EL underwent panel-based next-generation sequencing in this retrospective cohort study. The FBN1 genotypes were categorized into the dominant-negative (DN) group and the haploinsufficiency (HI) group.

Nanohelix Arrays with Giant Circular Dichroism through Patch-Enthalpy-Driven Self-Confined Self-Assembly of Janus Nanoparticles.

Plasmonic nanohelix arrays, exhibiting strong circular dichroism, are among the most promising optical chiral metamaterials. However, achieving chiral plasmonic effects in the visible range remains challenging with current manufacturing techniques, as it requires structures small enough to resonate at visible wavelengths. Herein, we propose a novel strategy for constructing nanohelix arrays through patch-enthalpy-driven self-confined self-assembly of Janus nanoparticles.

Fabrication of a Whitlockite/PLGA Scaffold with Hierarchical Porosity for Bone Repair.

Regenerating functional bone tissue in critical-sized defects remains a formidable issue. Bone-tissue engineering (BTE) scaffolds are emerging as potential alternatives to bone transplantation for the repair of bone defects. However, developing BTE scaffolds with unique bone-healing properties and natural bone porous structure is challenging.

Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43.

Background: Colonic motility dysfunction is a common symptom of ulcerative colitis (UC), significantly affecting patients' quality of life. Evidence suggests that glial cell line-derived neurotrophic factor (GDNF) plays a role in restoring colonic function.

Aim: To investigate whether GDNF enhances aberrant colonic motility in mice with experimental colitis connexin 43 (Cx43).

GATI-RS model using Bi-LSTM and multi-head attention mechanism to enhance online shopping experience for the elderly with accurate click-through rate prediction.

With the rapid development of e-commerce and the increasing aging population, more elderly people are engaging in online shopping. However, challenges they face during this process are becoming more apparent. This article proposes a recommendation system based on click-through rate (CTR) prediction, aiming to enhance the online shopping experience for elderly users.

Targeted-release budesonide: A comprehensive review on its potential in IgA nephropathy.

IgA nephropathy (IgAN) is characterized by the presence of IgA deposits in the glomerular mesangium, representing a prevalent form of primary glomerulonephritis worldwide. This condition is associated with a significant risk of progression to end-stage renal disease (ESRD). Hypertension, proteinuria, and reduced glomerular filtration rate (GFR) are established risk factors.

Ubiquitin specific protease 7 is a potential therapeutic target for gastric cancer.

Introduction: As a deubiquitinase, ubiquitin-specific protease 7 (USP7) plays a vital role in diverse cancers, nevertheless, its role in gastric cancer (GC), which is the fifth leading cause of death in diverse cancers worldwide, has rarely been reported.

Methods: To gain a comprehensive understanding about USP7 in the progression of GC, 287 paired GC tissues were collected and analyzed. ShRNA and small molecular inhibitor were used to investigate the impact of USP7 on cell proliferation.

The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial.

Introduction: Transsphenoidal endoscopic pituitary (TEP) tumor resection is performed through the nose via the sphenoid sinus to remove tumors from the pituitary gland. Also, enhanced recovery after surgery (ERAS) was adapted to reduce physical and physiological traumatic stress response of surgical patients.

Methods: A total of 174 patients who underwent TEP tumor resection in our department from August 2021 to June 2022 were randomly divided into non-ERAS group and ERAS group.

Predictors for the Efficacy of 4-Week Dupilumab Treatment in Atopic Dermatitis Patients.

Background: Atopic dermatitis (AD) is a common inflammatory disease with heterogeneous clinical features. Certain meaningful phenotypes and clinical features may help better classify AD patients for personalized medicine. To our knowledge, no ideal predictors have been found so far.

Benchmarking the high conductive two-dimensional layered structured NbS, ZrS, ReS and NbSe materials with zero energy bandgap ( ) for photocatalytic application: a DFT study.

Two-dimensional materials are among the most scientifically accessible materials in material science at the beginning of the twenty-first century. There has been interest in the monolayer transition metal dichalcogenide (TMDC) family because of its large active site surface area for UV photons of light for wastewater treatment. In the present work, density functional theory (DFT) is utilized to model the optical, structural and electrical properties of TMDCs such as NbS, ZrS, ReS and NbSe using the GGA-PBE simulation approximation.

Research Progress of Liver Cancer Recurrence Based on Energy Metabolism of Liver Cancer Stem Cells.

Objective: The aim of this study is to investigate the recurrence and progression of liver cancer by focusing on the energy metabolism of liver cancer stem cells.

Methods: A comprehensive literature search was conducted using databases including CNKI, PubMed, Wanfang, and Citexs to analyze the etiology and treatment of hepatocellular carcinoma (HCC), the factors and mechanisms contributing to HCC recurrence, and the impact of energy metabolism in HCC stem cells on the development of HCC. Furthermore, the association between HCC recurrence and the energy metabolism of HCC stem cells was examined.

Abnormal static and dynamic functional connectivity of striatal subregions in patients with obsessive-compulsive disorder.

Background: As a crucial node of the cortico-striato-thalamo-cortical (CSTC) loop, the striatum has long been considered to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Numerous neuroimaging studies have reported functional abnormalities of the striatum in OCD. However, altered dynamic functional connectivity (DFC) patterns of striatal subregions were rarely reported in patients with OCD.

Temporal Variation in Bacterial Community Characteristics Shaped by Habitat in a Reservoir Buffer Strip in China.

Habitat and temporal variation can both influence microbial community dynamics, although their relative importance in reservoir buffer zones with complex hydrology regimes and dramatically altered environments remains controversial. To elucidate this, we investigated spatiotemporal variation in soil bacterial diversity and ecological processes from the flooding period to the dry period (April and June, respectively) using high-throughput 16S amplicon sequencing in three habitats (abandoned cropland, grassland, and woodland) within the Chushandian Reservoir's buffer strip, China. The results showed that habitat was more important than temporal variation in shaping soil bacterial diversity and ecological processes in the reservoir buffer zone.

The triglyceride-glucose index is a promising predictor for the risk of cardiovascular disease in the diabetic population aged ≥60 years in the United States: a retrospective cohort study from NHANES (2007-2016).

Background: The predictive value of triglyceride-glucose index (TyG) for cardiovascular disease (CVD) in the US elderly diabetic patients is ambiguous. This study aimed to investigate the association between TyG index and the risk of CVD in an older US population with diabetes.

Methods: The study examined data from the 2007-2016 National Health and Nutrition Examination Survey (NHANES).

The six whole mitochondrial genomes for the species: features, evolution and phylogeny.

In this study, the complete mitogenomes of three species ( ZM79-3, ZM33-4 and sp. ZM41-5) were sequenced, assembled and compared with the other three previously sequenced mitogenomes ( VNIIKR SE Dcaul3, MSPL 10-6 and VNIIKR SE Dps12). The six mitogenomes were found to be circular DNA molecules, with lengths ranging from 53,646 bp to 108,865 bp.

Development of a novel label-free NIR aptasensor based on triphenylmethane dyes for rapid and sensitive detection of copper ions.

Heavy metal pollution, particularly from copper ions (Cu), poses a significant threat to both the ecological environment and human health. However, traditional copper ion analysis techniques are often hindered by the need for expensive equipment, labor-intensive sample preparation and skilled operation, which limits their effectiveness for field and real-time applications. In this work, we report a novel near-infrared aptamer sensor (NIRApt) that originates from the binding reaction between the DNA aptamer Apt and the fluorescent small molecule crystal violet (CV), enabling rapid detection of Cu through the competitive effect of Cu with Apt.