Study on preparation and performance of cement-stabilized macadam containing ground sludge gasification slag (GSGS).

Traditional cement-based road materials face problems of high energy consumption and carbon emissions, and the use of activated solid waste as a substitute for cementitious materials has been applied in road engineering. Sludge gasification slag (SGS), a product obtained from the pyrolysis and gasification of sludge, is a typical silicon-aluminum-rich solid waste that exhibits good compatibility with alkaline activation systems due to its potential activity. This study focuses on the component reconstruction mechanism of SGS in alkali-activated materials, employing cement (P) and carbide slag (CS) for synergistic modification, exploring the mechanism for enhancing the cementitious properties of sludge gasification slag under multi-component mixing conditions, and verifying its feasibility for use in cement-stabilized macadam.

Unveiling Ion-Pairing and Anion Dual Charge Carrier in Ca-Organic Batteries.

Calcium-organic batteries offer sustainable energy storage with high voltage, yet their reaction mechanisms remain unclear. Here, a hidden dual-ion charge storage mechanism is unveiled in poly(anthraquinone imide) (PAQI) using Ca(TFSI)₂/ether-based electrolytes, challenging the conventional Ca⁺-only storage model. It is demonstrated that Ca⁺-TFSI⁻ ion pairs co-bind to carbonyl groups during the first electron transfer, followed by TFSI⁻ dissociation to activate adjacent carbonyl sites in the second step-a process reversible upon charging.

Synergistic effect of corn straw and mulberry leaves fermantation in vitro and effects on growth performance and antioxidant capacity of sheep.

This study was to determine the synergistic effect of corn straw and mulberry leaves in sheep diet. Corn straw and mulberry leaves were mixed as culture substrate for six groups: 100:0 (T0), 80:20 (T20), 60:40 (T40), 40: 60 (T60), 20:80 (T80) and 0:100 (T100). The in vitro culture indicated that mulberry leaves exhibited a positive correlation with theoretical gas production (GP), cumulative GP, microbial crude protein concentration, and organic matter digestibility.

Theoretical Studies on the Competing Mechanism and Origin of Diastereoselectivity of NHC-Catalyzed Intramolecular [3 + 2] Annulations of Ynals.

Chiral tricyclic 6,5,5-fused rings exhibit structural diversity and possess important biological activities in the synthesis of natural products. However, predicting the possible mechanism and origin of stereoselectivity in these reactions remains a challenge. In this article, we conducted a theoretical investigation into the NHC-catalyzed intramolecular [3 + 2] annulations of ynals to generate tricyclic 6,5,5-fused rings.

HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification.

Background: Hepatocellular carcinoma is a fatal malignancy that lacking specific therapies. Homeobox B4 (HOXB4) was negatively correlated with poor prognosis in cancers, but its role in hepatocellular carcinoma has not been elucidated.

Results: We confirmed that HOXB4 was downregulated in hepatocellular carcinoma tissues and lower HOXB4 expression associated with poor prognosis.

E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma.

Background: Oral squamous cell carcinoma (OSCC) is one of the leading causes of cancer-related mortality worldwide due to its high aggressive potential and drug resistance. Previous studies have revealed an important function of HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 5 (HERC5) in cancer. Six GEO gene microarrays identified HERC5 as a significant upregulated gene in OSCC tissues or cells (log2 Fold change > 1 and adj.

Exploring a recurrence model for atypical meningioma based on multiparametric MRI radiomic and clinical characteristics: a multicenter retrospective cohort study.

Objectives: Atypical meningioma (AM) has a high recurrence rate. This study explored the factors associated with recurrence and built a predictive model for AM by combining radiomic and clinical features.

Methods: This retrospective cohort study enrolled 451 adult AM patients who underwent surgical treatment at three institutions between May 2012 and April 2024.

Motor developmental delay in preschoolers with autism spectrum disorders in China and its association with core symptoms and maternal risk factors: a multi-center survey.

Background: Motor disturbance, as a related symptom of autism spectrum disorders (ASD), has not received the attention it deserves. We aimed to investigate the different degrees of motor developmental delay and influencing factors in Chinese preschool children with ASD, in order to enhance people's awareness of motor developmental delay in ASD children.

Methods: We recruited 1,256 ASD children aged 2-6 years from the China Multi-Center Preschool Autism Project (CMPAP).

Frailty mediated the associations of fine particulate matter with depression and anxiety: Findings from the UK Biobank.

Background: The role of frailty in the associations of fine particulate matter (PM2.5) with depression and anxiety was unknown.

Methods: This study is a longitudinal population-based cohort study.

Threshold size criterion to suspect malignant supraclavicular lymph node < 10 mm in esophageal cancer.

Objectives: To determine the threshold size for predicting metastasis of supraclavicular lymph nodes (SCLNs) < 10 mm on axial and multiplanar reconstruction CT in esophageal squamous cell carcinoma (ESCC).

Methods: This retrospective, multicenter study received approval from three institutional review boards, which waived informed consent. Patients with ESCC had ultrasound-guided fine-needle aspiration biopsy (US-FNAB) for SCLNs, with contrast-enhanced CT performed within 2 weeks prior to US-FNAB.

Stroke Mechanisms in Intracranial Atherosclerotic Disease: A Modified Classification System and Clinical Implications.

Background: In patients with symptomatic intracranial atherosclerotic stenosis (sICAS), recent evidence has suggested an association between artery-to-artery embolism (AAE) and cortical borderzone (CBZ) infarcts.

Methods: We recruited patients with 50-99% anterior-circulation sICAS in this cohort. Stroke mechanisms were categorized as isolated parent artery atherosclerosis occluding penetrating artery (PAO), isolated AAE, isolated hypoperfusion, and mixed mechanisms, using two classification systems.

Label-free electrochemical biosensor based on AuNPs and PCL-b-PHEAA amphiphilic copolymer for highly sensitive detection of CEA.

Carcinoembryonic antigen (CEA) is a broad-spectrum tumor marker expressed in various human cancers. In this study, the electrode loaded with AuNPs was used to replace the traditional electrode, providing more active sites for biological probes and significantly enhancing the sensitivity of the sensor. By constructing an aptamer-antigen-aptamer "sandwich structure," highly selective detection was achieved, effectively avoiding cross-reactions.

Influence of soil-rock composite stratum on mechanical response and failure modes of underground utility tunnel.

This research combines scaled model experiments with theoretical analysis to investigate the impact of underground utility tunnels (UUTs) on foundation bearing capacity and to examine the interaction between soil-rock composite strata and the stress-strain responses of the tunnel. The findings indicate that UUTs alter the foundation mechanism by reducing soil depth, streamlining the load transfer path, and causing stress to converge at the tunnel's top. Additionally, the results reveal that the influence range of the tunnel on both sides is approximately 1.

A safety risk assessment method for TBM tunnel construction based on attribute interval identification theory.

Based on the identification and analysis of safety risks in TBM tunnel construction, we construct a comprehensive safety risk dynamic evaluation index system tailored to this context. To account for the dynamic nature of safety risks during TBM tunnel construction, variable weight theory is incorporated, allowing for a more accurate reflection of the time-varying importance of risk indicators. Building on the theoretical framework of attribute interval recognition theory, we establish a TBM tunnel construction safety risk evaluation model grounded in attribute interval theory.

Post-cardiovascular disease healthy lifestyle, inflammation and metabolic biomarkers, and risk of dementia: a population-based longitudinal study.

Background: Cardiovascular disease (CVD) is associated with an increased risk of dementia, but the impact of healthy lifestyle on post-CVD dementia remains unclear.

Objectives: The aim of this study was to explore the association between post-CVD healthy lifestyle factors and risk of dementia. We further examined whether inflammation and metabolic biomarkers played a role in this association.

Status and factors influencing health-related quality of life in patients with non-alcoholic fatty liver disease in Hangzhou: a cross-sectional study.

Objective: Due to rapid economic development and the unique lifestyles, cultures and customs of Hangzhou, non-alcoholic fatty liver disease (NAFLD) has attracted widespread attention, with a prevalence rate of 35-45%. In this study, we used the Chinese version of the Chronic Liver Disease Questionnaire for NAFLD (CLDQ-NAFLD) to investigate the current health-related quality of life (HRQL) among patients with NAFLD and analyse the influencing factors, which provides a reference for improving the patients' HRQL.

Design: A cross-sectional design.

Germline mutation in Cbl proto-oncogene B is associated with inherited thrombocytopenia and predisposes megakaryocytes to ferroptosis.

Background: Inherited thrombocytopenias (ITs) are a group of heterogeneous diseases characterized by low platelet counts and bleeding diathesis. ITs are primarily caused by mutations in genes involved in megakaryocyte differentiation, maturation and platelet release. To date, ITs encompass 45 disorders with different degrees of variability in the prognosis.

Effect of prednisone plus either adalimumab or cyclosporine on dermatological symptoms in Vogt-Koyanagi-Harada disease: systemic outcomes from a randomized trial.

Background: Vogt-Koyanagi-Harada (VKH) disease causes vitiligo, poliosis, and alopecia.

Objective: To investigate the effect of prednisone plus either adalimumab or cyclosporine-based immunosuppression on VKH dermatological disorders using ancillary data from a VKH eye disease trial.

Methods: Patients with VKH disease treated with individualized prednisone tapering (maximum daily dose, 40 mg; maximum duration, 6 months) were randomized to adjunctive adalimumab (N=54) or cyclosporine (N=56).

A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans.

To identify genomic regions subject to positive selection that might contain genes involved in high-altitude adaptation (HAA), we performed a genome-wide scan by whole-genome sequencing of Tibetan highlanders and Han lowlanders. We revealed a collection of candidate genes located in 30 genomic loci under positive selection. Among them, MCUR1 at 6p23 was a novel pronounced candidate.

Socioeconomic developments drove regime shifts of agriculture-ecology-economy nexus of social-ecological system: Four-decade lessons from southeast China.

Urbanization has been recognized as an effective measure to promote socioeconomic development; however, it leads to cropland and habitat loss and aggravates ecosystem services (ESs), which have not been sufficiently and systematically revealed from the perspective of agriculture-ecology-economy nexus (AEEN). To address these knowledge gaps, this novel study adopted a hotspot of urbanization to examine the response dynamics of ESs and agricultural production to urbanization, as well as their regime shifts and interactions, by employing statistical records, satellite images, and incorporating biophysical model-based ESs into AEEN. In the past four decades, Guangdong has undergone rapid urbanization and associated landscape transformations, represented by cropland and wetland shrinkage and urban expansion, particularly around central city clusters, which have caused ESs degradation and grain productivity reduction.

Polypropylene microplastic exposure modulates multiple metabolic pathways in tobacco leaves, impacting lignin biosynthesis.

The adverse effects of microplastics (MPs) and nanoplastics (NPs) on plant growth have gained significant attention. However, the response of tobacco plants to polypropylene microplastics (PP-MPs) remains poorly understood. To address this, a microcosm experiment was conducted in which tobacco seedlings were exposed to PP-MPs at varying concentrations (100 and 1000 mg/kg) and particle sizes (20 nm and 100 µm) for 48 days in red soil.