Enhanced Hot/Free Electron Effect for Photocatalytic Hydrogen Evolution Based on 3D/2D Graphene/MXene Composite.

Photocatalytic hydrogen production through water splitting represents a promising strategy to store solar energy as chemical energy. Current photocatalysts primarily focus on traditional semiconductor materials, such as metal oxides, sulfides, nitrides, g-CN, etc. However, these materials often suffer from large bandgap and fast charge recombination, which limit sunlight utilization and result in unsatisfactory photon conversion efficiency.

Fluorescence Quenching of Graphene Quantum Dots from Orange Peel for Methyl Orange Detection.

Methyl orange (MO) is an organic synthetic dye widely used in laboratory and industrial applications. In laboratory settings, it serves as an acid-base indicator due to its distinct color change in both acidic and alkaline environments. Industrially, it is primarily utilized in the textile industry for its ultraviolet (UV) absorption properties.

Nano Cobalt-Loaded Porous Carbon Derived from Waste Plastic for Efficient Persulfate Activation and Tetracycline Degradation.

The excessive utilization and emission of waste plastics have caused serious damage to the environment, and it is of great significance to explore high-value utilization methods for these waste plastics. To address this challenge, functional nano cobalt-loaded porous carbon materials (CoPC) with excellent antibiotic wastewater removal properties were prepared by one-step pyrolysis using waste PET plastics as a carbon source, a process described in this paper. Characterization revealed that the obtained CoPC-2 catalysts had a high degree of defects, a large specific surface area (343.

Low-Crystallized Carbon as an Electron Mediator in g-CN/C/TiO for Enhancing Photocatalytic Degradation of Antibiotics.

Photodegradation of antibiotics based on photocatalytic semiconductors is a promising option to alleviate water pollution. Despite its limitations, TiO-based photocatalysts are still the most widely studied materials for pollutant degradation. In this work, a pomegranate-like g-CN/C/TiO nano-heterojunction was constructed using the hydrothermal-calcination method, consisting of interconnected small crystals with a dense structure and closely contacted interface.

Recent Progress in Bismuth Vanadate-Based Photocatalysts for Photodegradation Applications.

Bismuth vanadate (BiVO), a well-known semiconductor photocatalyst with various advantages, has shown great potential in addressing energy and environmental issues. However, its inherent drawbacks restrict the photocatalytic performance of pure BiVO. In the past few years, many efforts have been devoted to improving the catalytic activity of BiVO and revealing the degradation mechanism in depth.

Distribution and Pharmacokinetic Characteristics of Cordycepin in Rat: Investigated by UHPLC-HRMS/MS and Blood-Brain Synchronous Microdialysis.

Cordycepin, a natural adenosine derivative, exhibits multiple pharmacological effects on organisms. However, its distribution and metabolic characteristics have not been fully elucidated in vivo. In this study, ultra-high liquid chromatography tandem high-resolution mass spectrometry (UHPLC-HRMS/MS) was used to investigate the pharmacokinetic characteristics and effects of cordycepin on endogenous adenosine and inosine.

The role of protein phosphorylation modifications mediated by iron metabolism regulatory networks in the pathogenesis of Alzheimer's disease.

Alzheimer's disease (AD) is a severe neurodegenerative disease characterized mainly by the formation of amyloid beta (Aβ) plaques and abnormal phosphorylation of tau. In recent years, an imbalance in iron homeostasis has been recognized to play a key role in the pathological process of AD. Abnormal iron accumulation can activate various kinases such as glycogen synthase kinase-3β, cyclin-dependent kinase 5, and mitogen-activated protein kinase, leading to abnormal phosphorylation of tau and amyloid precursor protein, and accelerating the formation of Aβ plaques and neurofibrillary tangles.

Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression.

Hepatocellular carcinoma (HCC) ranks among the most prevalent and lethal cancers affecting humans. Currently, there are limited effective treatments available for HCC. Carfilzomib, a proteasome inhibitor, is known to exert anti-HCC activities; however, its underlying mechanisms of action remain unclear.

A Novel Disulfidptosis-Related Diagnostic Gene Signature and Differential Expression Validation in Ischaemic Cardiomyopathy.

Ischaemic cardiomyopathy (IC) predominantly arises from prolonged deprivation of oxygen in the coronary arteries, resulting in compromised cardiac contractility or relaxation. This study investigates the role of disulfidptosis-associated genes (DiGs) in IC. Through the analysis of datasets GSE5406 and GSE57338, we explored the association between DiGs and immune characteristics to identify crucial genes contributing to IC development.

Influence of SARS-CoV-2 Infection on the Perioperative Period of Functional Endoscopic Sinus Surgery.

Objective: This study was aimed at exploring the safety and timing of functional endoscopic sinus surgery (FESS) in patients after mild-to-moderate SARS-CoV-2 infection.

Methods: The study group comprised 63 adult inpatients who underwent FESS in our department after mild-to-moderate SARS-CoV-2 infection between December 2022 and February 2023. Sixty adult patients without prior SARS-CoV-2 infection were randomly selected as the control group.

Pressure-Driven Circularly Polarized Luminescence Enhancement and Chirality Amplification.

Achieving ultrahigh-color-purity circularly polarized luminescence (CPL) in low-dimensional chiral perovskites is challenging due to strong electron-phonon coupling caused by lead halide octahedral distortion. Herein, the circularly polarized piezoluminescence behaviors of six novel chiral perovskites, (/-3-XPEA)PbBr (PEA = phenethylamine; X = F, Cl, Br), were systematically investigated. Upon compression, (/-3-ClPEA)PbBr exhibits significant piezofluorochromic behaviors, transforming from yellow CPL to ultrahigh-color-purity deep-blue CPL.

Targeting NAD + biosynthesis suppresses TGF-β1/Smads/RAB26 axis and potentiates cisplatin cytotoxicity in non-small cell lung cancer brain metastasis.

Nicotinamide adenine dinucleotide (NAD) plays an important role in tumor progression, but its role in non-small cell lung cancer with brain metastasis (NSCLC BM) remains unclear. Herein, we investigated NAD biosynthesis targeting as a new therapeutic strategy for NSCLC BM. Therapeutic activity of nicotinamide phosphoribosyl transferase (NAMPT) inhibitors was evaluated in mouse models of NSCLC BM and using various assays such as NAD quantitation, cell viability, and apoptosis assays.

Clinical staff's perceptions of transitional care from hospital to home for stroke patients: a qualitative study.

Background: The transition from hospital to home is a critical period for stroke survivors and their caregivers. This study explores the clinical staff's attitudes and perspectives on transitional care (from hospital to home) for stroke patients in the neurology department.

Methods: This qualitative descriptive phenomenological study involved semi-structured interviews with 15 clinical staff members in the neurology department of a tertiary hospital, conducted either face-to-face or via telephone.

Somatostatin-expressing interneurons of prefrontal cortex modulate social deficits in the Magel2 mouse model of autism.

Dysfunction in social interactions is a core symptom of autism spectrum disorder (ASD). Nevertheless, the neural mechanisms underlying social deficits in ASD are poorly understood. By integrating electrophysiological, in vivo fiber photometry, viral-mediated tracing, optogenetic and pharmacological stimulation, we show reduced intrinsic excitability and hypoactivity of SOM interneurons in medial prefrontal cortex (mPFC) in Magel2-deficient mice, an established ASD model, were required to social defects.

Using network analysis to identify central symptoms of depression and anxiety in different profiles of infertility patients.

Background: Depression and anxiety were not only common but also with serious consequence in infertility patients. The current study endeavors to define distinct depression and anxiety profiles of infertility patients and identify central symptoms within different profiles to facilitate targeted interventions.

Method: The research employed K-means Clustering to delineate the depression and anxiety profiles, followed by a repetition of the analysis using Latent Class Analysis (LCA).

PKN2 enhances the immunosuppressive activity of polymorphonuclear myeloid-derived suppressor cells in esophageal carcinoma by mediating fatty acid oxidation.

Background: Myeloid-derived suppressor cells (MDSCs) in tumor microenvironment reduce the efficacy of immunotherapy. PKN2 plays a role in colon cancer, but its function in esophageal cancer (EC) remains unclear. This study investigated PKN2 expression in MDSCs derived from EC tissues and determined whether PKN2 regulates immunosuppressive activity of MDSCs by mediating fatty acid oxidation (FAO).

Utilizing SMOTE-TomekLink and machine learning to construct a predictive model for elderly medical and daily care services demand.

This study aims to construct a prediction model for the demand for medical and daily care services of the elderly and to explore the factors that affect the demand for medical and daily care services of the elderly. In this study, a questionnaire survey on the demand for medical and daily care services of 1291 elderly was conducted using multi-stage stratified whole cluster random sampling. SPSS21.

Semantic SLAM system for mobile robots based on large visual model in complex environments.

Simultaneous localization and mapping (SLAM) plays an important role in many fields, one of which is to help unmanned devices such as drones, self-driving cars and intelligent robots to achieve precise positioning and mapping. However, when facing complex or changing surroundings, especially when healthcare robots face a large number of mobile healthcare workers and patients in wards, the hospital environment is relatively complex, and the traditional positioning and mapping methods based on geometric features, such as points and lines, are not able to achieve accurate positioning and mapping results for healthcare robots. This paper mainly focuses on the characteristics of complex dynamic environment, and proposes a method to obtain semantic information of surrounding ring and dynamic point culling strategy for robot localisation and mapping.

Major depressive disorder on a neuromorphic continuum.

The heterogeneity of major depressive disorder (MDD) has hindered clinical translation and neuromarker identification. Biotyping facilitates solving the problems of heterogeneity, by dissecting MDD patients into discrete subgroups. However, interindividual variations suggest that depression may be conceptualized as a "continuum," rather than as a "category.

Acupuncture combined with pelvic floor rehabilitation training for postpartum stress urinary incontinence: A systematic review and meta-analysis.

ObjectivePostpartum stress urinary incontinence is a common postpartum complication. Acupuncture combined with pelvic floor rehabilitation training has certain clinical effects. This systematic review and meta-analysis aims to investigate the efficacy of acupuncture combined with pelvic floor rehabilitation training in the treatment of postpartum stress urinary incontinence.

HSV-1 as a gene delivery platform for cancer gene therapy.

Herpes simplex virus type 1 (HSV-1) is a DNA virus with strong replication capabilities, a large genomic payload (≥30 kb), and low toxicity, making it a prominent vector in cancer gene therapy. Clinically approved oncolytic HSV-1 (oHSV-1) variants, such as T-VEC and G47Δ, demonstrate safety and efficacy in localized tumors, but face challenges in treating metastatic disease. To address this issue, next-generation oHSV-1 designs focus on precision targeting and immune remodeling through the delivery of multiple exogenous genes.

Effect of ambidextrous leadership on clinical nurse leadership: The mediating role of psychological empowerment among critical care nurses.

Background: In critical care departments, the clinical leadership of nurses who specialize in critical care nursing significantly influences care quality and clinical outcomes. The leadership styles of head nurses are closely associated with clinical nurse leadership. Ambidextrous leadership, which integrates transactional and transformational leadership, is a common leadership style.

Expert consensus on clinical genome sequencing interpretation and reporting.

Genome sequencing (GS) refers to a technology that comprehensively and systematically detects the DNA sequences of an individual's nuclear and mitochondrial genomes. It aims to identify genetic variants and investigate their roles in human health and disease progression. As an emerging diagnostic tool, GS offers significant support for clinical diagnosis due to its high throughput, accuracy, and comprehensiveness.

Tailoring foaming behavior of poly(lactic acid) by different geometric sizes of bio-based polyamide.

Naturally derived materials have attracted much attention owing to the demand of sustainability. In this work, bio-based polyamide was used to tailor the foaming behavior of poly(lactic acid) by dispersing into different geometric sizes. The results showed that both micro-sized spherical and fibrillar polyamide markedly shortened the half-crystallization time of poly(lactic acid) in isothermal crystallization process, while nanofibrils played a better role on promoting crystallization than submicron spheres.

Postharvest ripening-induced modification of cell wall polysaccharide affects plum phenolic bioavailability.

The mechanisms by which cell wall polysaccharides regulate phenolic release are essential to human health. Scanning electron microscopy (SEM), surface area and porosimetry analyzer, high-performance liquid chromatography (HPLC), and atomic force microscopy (AFM) indicated that compared to fresh plums, postharvest ripening reduced chain linearity in the homogalacturonan region of pectins and the degree of branching of RG-I; pectin and hemicellulose underwent solubilization and depolymerization by cell wall-degrading enzymes; and the specific surface area of cellulose was reduced by 19.5 %-26.