Optical coherence tomography angiography for visualization of retinal capillary plexuses in pachychoroid neovasculopathy.

Objective: To evaluate retinal capillary plexus alterations in patients with pachychoroid neovasculopathy (PNV) by optical coherence tomographic angiography (OCTA).

Design: Retrospective observational study.

Participants: The study included 43 patients with PNV (43 eyes, PNV group) and 43 normal eyes (control group).

Secretogranin III as a novel target for the therapy of choroidal neovascularization.

Wet age-related macular degeneration (AMD) with choroidal neovascularization (CNV) is a leading cause of vision loss in the elderly. The advent of anti-vascular endothelial growth factor (VEGF) drugs represents a major breakthrough in wet AMD therapy but with limited efficacy to improve visual acuity. Secretogranin III (Scg3, SgIII) was recently discovered as a novel angiogenic factor with VEGF-independent mechanisms.

Assessment of capillary dropout in the superficial retinal capillary plexus by optical coherence tomography angiography in the early stage of diabetic retinopathy.

Background: To assess capillary dropout in the superficial retinal capillary plexus (SCP) by optical coherence tomography angiography (OCTA) in the early stage of diabetic retinopathy (DR).

Methods: This study was a cross-sectional observational study. Patients that underwent OCTA examinations in our hospital between November 2015 and May 2016 were included in the study.

Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease.

Angiogenic factors play an important role in the pathogenesis of diabetic retinopathy (DR), neovascular age-related macular degeneration (nAMD) and retinopathy of prematurity (ROP). Pleiotrophin, a well-known angiogenic factor, was recently reported to be upregulated in the vitreous fluid of patients with proliferative DR (PDR). However, its pathogenic role and therapeutic potential in ocular vascular diseases have not been defined in vivo.

Assessment of choroidal osteoma complicating choroidal neovascularization by optical coherence tomography angiography.

Purpose: Choroidal osteoma (CO) frequently leads to progressive visual loss due to complications of secondary choroidal neovascularization (CNV).We report herein the function of optical coherence tomography angiography (OCTA) in observation of CO complicating CNV.

Methods: A 25-year-old female presented to our hospital with chief complaint of sudden unilateral visual acuity decrease for one week, with metamorphopsia in the left eye.

Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy.

Diabetic retinopathy (DR) is a leading cause of vision loss with retinal vascular leakage and/or neovascularization. Current antiangiogenic therapy against vascular endothelial growth factor (VEGF) has limited efficacy. In this study, we applied a new technology of comparative ligandomics to diabetic and control mice for the differential mapping of disease-related endothelial ligands.