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Comprehensive Genome Analysis of Carbapenem-Resistant strains, an Emerging Multidrug-Resistant Bacteria in Hospitals.

Antimicrob Agents Chemother

September 2019

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University

We report the characterization of six carbapenem-resistant (CRRS) in our hospital and a genomic analysis of 58 publicly available isolates. CRRS isolates are sporadically identified around the world and different transposons carrying carbapenemases were the resistant mechanisms. Mobile genetic elements play an important role in acquiring antibiotic resistant genes from the hospital.

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