9 results match your criteria: "Zhejiang University Medical College Affiliated Sir Run Run Shaw Hospital[Affiliation]"
Pan-cancer analysis of oncogenic role of CEP55 and experiment validation in clear cell renal cell carcinoma.
Sci Rep
November 2024
Department of Urology, The affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.
Immunotherapy has emerged as a vital component in the contemporary landscape of cancer treatment. Recent studies have indicated that CEP55 plays an oncogenic role; however, its specific mechanisms in promoting tumor proliferation and its potential value in prognosis and immunotherapy prediction across various cancers remain to be elucidated. CEP55 was significantly overexpressed in 22 cancer types compared with their adjacent normal tissues.
View Article and Find Full Text PDFCollecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptor.
J Adv Res
February 2024
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, Zhejiang 310000, China. Electronic address:
Article Synopsis
- NCOR1 is a protein that has been linked to cardiovascular diseases, but its role in kidney function and blood pressure regulation was previously unclear.* -
- Research involving NCOR1 knockout mice showed that the absence of this protein led to increased blood pressure and worsened kidney damage, especially after being exposed to certain hypertensive substances.* -
- The study found that NCOR1 regulates sodium reabsorption in the kidneys by interacting with the mineralocorticoid receptor, suggesting that targeting NCOR1 could be a potential strategy for managing hypertension.*
Total cholesterol and mortality in peritoneal dialysis: a retrospective cohort study.
BMC Nephrol
May 2023
Department of Nephrology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, No.600, Yi Shan Road, Shanghai, 200233, China.
Background: Total cholesterol is inversely associated with mortality in dialysis patients, which seems implausible in real-world clinical practice. May there be an optimal range of total cholesterol associated with a lower mortality risk? We aimed to evaluate the optimal range for peritoneal dialysis (PD) patients.
Methods: We conducted a retrospective real-world cohort study of 3565 incident PD patients from five PD centers between January 1, 2005, and May 31, 2020.
Preexisting Cardiovascular Disease, Hypertension, and Mortality in Peritoneal Dialysis.
Rev Cardiovasc Med
January 2023
Department of Nephrology, Zhejiang University Medical College Affiliated Sir Run Run Shaw Hospital, 310016 Hangzhou, Zhejiang, China.
Background: Preexisting cardiovascular disease (CVD) and hypertension are each associated with poor prognosis in peritoneal dialysis (PD) patients. Joint associations of preexisting CVD and hypertension have not been comprehensively evaluated in this population.
Methods: We conducted a retrospective cohort study of 3073 Chinese incident PD patients from five dialysis centres between January 1, 2005, and December 31, 2018.
Hyperlipidemia and mortality in patients on peritoneal dialysis.
BMC Nephrol
October 2022
Department of Nephrology, Zhejiang University Medical College Affiliated Sir Run Run Shaw Hospital, Qingchun Road 3rd, 310016, Hangzhou, Zhejiang Province, China.
Article Synopsis
- The study assessed how hyperlipidemia affects mortality in patients starting continuous ambulatory peritoneal dialysis (CAPD) using a retrospective analysis of 2,939 patients over 35 months.
- While overall mortality risk was similar for patients with and without hyperlipidemia, those with hyperlipidemia showed a significantly higher risk of death after 48 months.
- Hypertension was found to further increase the mortality risk associated with hyperlipidemia, indicating that these two factors together could pose greater health risks for CAPD patients.
Low-Density Lipoprotein Cholesterol and Mortality in Peritoneal Dialysis.
Front Nutr
July 2022
Department of Nephrology, Zhejiang University Medical College Affiliated Sir Run Run Shaw Hospital, Hangzhou, China.
Article Synopsis
- - This study examined the relationship between low-density lipoprotein cholesterol (LDL-C) levels and mortality risks in 3,565 new dialysis patients from China, suggesting a U-shaped relationship between LDL-C levels and health outcomes.
- - The findings revealed that both high and low LDL-C levels increased the risk of death from all causes and specifically from cardiovascular issues, with significant figures showing hazard ratios that indicate heightened risk.
- - Additionally, malnutrition appeared to influence this relationship, as patients with low or high LDL-C and malnutrition had an even greater risk of cardiovascular mortality, highlighting the importance of managing LDL-C levels and nutritional status in dialysis patients.
Albumin to Total Cholesterol Ratio and Mortality in Peritoneal Dialysis.
Front Med (Lausanne)
June 2022
Department of Nephrology, Zhejiang University Medical College Affiliated Sir Run Run Shaw Hospital, Hangzhou, China.
Background: Serum albumin and total cholesterol are associated with mortality. In clinical practice, evaluating the association of combining album and total cholesterol with mortality may be more reasonable. Thus, we examined the association between serum albumin to total cholesterol ratio and mortality in peritoneal dialysis (PD) patients.
View Article and Find Full Text PDFCreatine Kinase and Mortality in Peritoneal Dialysis.
Front Cardiovasc Med
May 2022
Department of Nephrology, Zhejiang University Medical College Affiliated Sir Run Run Shaw Hospital, Hangzhou, China.
Background: The association between serum creatine kinase and mortality in patients with peritoneal dialysis (PD) remained unknown.
Methods: We retrospectively collected data on 3,446 incident patients with from five PD centers in China between 1 January 2005 and 31 May 2020. Creatine kinase was collected 1 week before the start of PD.
Lack of microRNA-155 ameliorates renal fibrosis by targeting PDE3A/TGF-β1/Smad signaling in mice with obstructive nephropathy.
Cell Biol Int
November 2018
Department of Nephrology, Zhejiang University Medical College Affiliated Sir Run Run Shaw Hospital, Qingchun Road 3rd, Hangzhou 310016, Zhejiang Province, China.
Although microRNA-155 (miR-155) is implicated in the pathogenesis of several fibrotic diseases, information regarding its functional role in renal fibrosis is limited. The current study aims to investigate the effects of miR-155 on renal fibrosis in unilateral ureteral occlusion (UUO) mice. MiR-155 level was significantly increased in renal tissues of UUO mice and TGF-β1-treated HK2 cells.
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