Relational Integration Training Modulated the Frontoparietal Network for Fluid Intelligence: An EEG Microstates Study.

Relational integration is a key subcomponent of working memory and a strong predictor of fluid intelligence. Both relational integration and fluid intelligence share a common neural foundation, particularly involving the frontoparietal network. This study utilized a randomized controlled experiment to examine the effect of relational integration training on brain networks using electroencephalogram (EEG) and microstate analysis.

Cost-effective adaptations increase rice production while reducing pollution under climate change.

Rice is a major source of greenhouse gas (GHG) and nitrogen pollution. While best management practices have been developed to enhance the sustainability of rice production under current climates, their adaptability and efficacy under future climate scenarios remain uncertain. Here we evaluated 49 best management practices across global grid cells of rice-producing areas in terms of increasing rice production, reducing GHG emissions and minimizing nitrogen pollution under future climate conditions.

FTO Suppresses Proliferation and Induces Apoptosis of T98G Glioblastoma Cells via N6-methyladenosine Modification of GSTO1.

Glioblastoma (GBM) is the most malignant type of glioma with a very poor prognosis. N6-methyladenosine (m6A) is well-documented to be involved in GBM progression, and FTO is a demethylase. GSTO1 is also associated with tumor progression.

A genome-wide association study identifies genetic variants associated with hip pain in the UK Biobank cohort (N = 221,127).

Hip pain is a common musculoskeletal complaint that leads many people to seek medical attention. We conducted a primary genome-wide association study (GWAS) on the hip pain phenotype within the UK Biobank cohort. Sex-stratified GWAS analysis approach was also performed to explore sex specific variants associated with hip pain.

An improved spatially downscaled solar-induced chlorophyll fluorescence dataset from the TROPOMI product.

Solar-induced chlorophyll fluorescence (SIF) is an indicator of vegetation photosynthesis, and multiple satellite SIF products have been generated in recent years. However, current SIF products are limited for applications toward vegetation photosynthesis monitoring because of low spatial resolution or spatial discontinuity. This study uses a spatial downscaling method to obtain a redistribution of the original TROPOspheric Monitoring Instrument (TROPOMI) SIF (OSIF).

Novel inhibitors of the (VIBVN) NAT protein identified through pharmacophore modeling.

Arylamine N-acetyltransferases (NATs, E.C. 2.

A novel RRT*-Connect algorithm for path planning on robotic arm collision avoidance.

To address the limitations of the original algorithm, several optimization techniques are proposed. This article presents an original RRT*-Connect algorithm for the planning of obstacle avoidance paths on robotic arms. These strategies include implementing a target biasing algorithm, using elliptic space sampling to enhance the sampling process, the revision of the cost function to better guide path planning, and implementing an artificial potential field and gradient descent strategy to design adaptive step sizes.

Random resistive memory-based deep extreme point learning machine for unified visual processing.

Visual sensors, including 3D light detection and ranging, neuromorphic dynamic vision sensor, and conventional frame cameras, are increasingly integrated into edge-side intelligent machines. However, their data are heterogeneous, causing complexity in system development. Moreover, conventional digital hardware is constrained by von Neumann bottleneck and the physical limit of transistor scaling.

Association of domain-specific physical activity with nocturia: a population-based study.

Nocturia is the most prevalent lower urinary tract symptom (LUTS) and is closely associated with various diseases and social burdens. Research on the relationship between physical activity and various diseases has progressed significantly. However, the association between nocturia and physical activity has received limited attention in prior studies.

Microenvironment-confined kinetic elucidation and implementation of a DNA nano-phage with a shielded internal computing layer.

Multiple receptor analysis-based DNA molecular computation has been developed to mitigate the off-target effect caused by nonspecific expression of cell membrane receptors. However, it is quite difficult to involve nanobodies into molecular computation with programmed recognition order because of the "always-on" response mode and the inconvenient molecular programming. Here we propose a spatial segregation-based molecular computing strategy with a shielded internal computing layer termed DNA nano-phage (DNP) to program nanobody into DNA molecular computation and build a series of kinetic models to elucidate the mechanism of microenvironment-confinement.

Dynamics of the mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis.

The multi-enzyme pyruvate dehydrogenase complex (PDHc) links glycolysis to the citric acid cycle and plays vital roles in metabolism, energy production, and cellular signaling. Although all components have been individually characterized, the intact PDHc structure remains unclear, hampering our understanding of its composition and dynamical catalytic mechanisms. Here, we report the in-situ architecture of intact mammalian PDHc by cryo-electron tomography.

Challenging the ideal strength limit in single-crystalline gold nanoflakes through phase engineering.

Materials usually fracture before reaching their ideal strength limits. Meanwhile, materials with high strength generally have poor ductility, and vice versa. For example, gold with the conventional face-centered cubic (FCC) phase is highly ductile while the yield strength (~10MPa) is significantly lower than its ideal theoretical limit.

Effect of propofol and ciprofol in patients undergoing bronchoscopy: protocol for a double-blind, randomised controlled trial.

Introduction: Propofol is a fast-acting intravenous anaesthetic widely used for sedation and anaesthesia in gastrointestinal endoscopy, bronchoscopy, and the induction/maintenance of general anaesthesia in outpatients and inpatients; however, propofol has several undesirable effects, including injection pain, which affects the physical and mental health of patients, and cardiopulmonary depression, characterised by hypotension, bradycardia and apnea, which commonly occur in clinical practice. Ciprofol (HSK3486) is a propofol analogue with good clinical safety, high potency and some advantages over propofol, including lower injection pain and haemodynamic depression in patients undergoing gastroscopy and colonoscopy. This study aims to compare the impact of equivalent effective doses of propofol and ciprofol on haemodynamic changes in patients undergoing bronchoscopy under general anaesthesia.

Impact of anesthetic methods on outcomes for patients with large core stroke undergoing endovascular treatment.

Background: The optimal anesthetic method for endovascular therapy in acute large core stroke remains unclear. This study aimed to evaluate the impact of anesthetic methods on outcomes in patients with large core stroke.

Methods: This study was a subanalysis of a prospective, multicenter registry at 38 stroke centers in China.

Automated Laser-Assisted Single-Cell Sorting for Cell Functional and RNA Sequencing.

Accurate and efficient sorting of single target cells is crucial for downstream single-cell analysis, such as RNA sequencing, to uncover cellular heterogeneity and functional characteristics. However, conventional single-cell sorting techniques, such as manual micromanipulation or fluorescence-activated cell sorting, do not match current demands and are limited by low throughput, low sorting efficiency and precision, or limited cell viability. Here, we report an automated, highly efficient single-cell sorter, integrating laser-induced forward transfer (LIFT) with a high-throughput picoliter micropore array.

Dapagliflozin plus calorie restriction for remission of type 2 diabetes: multicentre, double blind, randomised, placebo controlled trial.

Objective: To assess the effect of dapagliflozin plus calorie restriction on remission of type 2 diabetes.

Design: Multicentre, double blind, randomised, placebo controlled trial.

Setting: 16 centres in mainland China from 12 June 2020 to 31 January 2023.

Preparation of silane-free porous structure hyperelastic phosphorylated chitosan sponge reinforced with bamboo activated carbon and its efficient PM2.5 removal.

Chitosan (CS) based sponge shows important potential applications in adsorption, filtration, sensing, etc., which often requires good deformation-recovery ability that is usually achieved under the help of silane elastomers. Herein, a simple but innovative strategy was proposed that only bamboo activated carbon (BAC) was employed as the reinforcer to construct highly elastic phosphorylated chitosan (P-CS) sponge with through-hole structure like layer-support by freeze drying.

Highly stretchable, conductive, and self-adhesive starch-based hydrogel for high-performance flexible electronic devices.

To achieve the green and sustainable development of environment, biocompatible hydrogels with exceptional ionic conductivity and flexibility are highly desired for intelligent and wearable sensors. However, it remains a great challenge to obtain biopolymer hydrogel-based sensors with high transparency, excellent mechanical properties, and good adhesion ability simultaneously. Herein, starch/polyacrylamide double-network hydrogel is achieved to endow the multifunctionality of traditional hydrogel sensor.

Integrating the modified amphiphilic Eleocharis tuberosa starch to stabilize curcuminoid-enriched Pickering emulsions for enhanced bioavailability, thermal stability, and retention of the hydrophobic bioactive compound.

The study involves the modification of a non-conventional starch isolated from the under-utilized variety of Chinese water chestnut (CWC (Eleocharis tuberosa) and integrating it to fabricate stabilized and curcumin-enriched Pickering emulsions with enhanced bioavailability, thermal stability, and retention of encapsulated curcumin. A time-efficient, semi-dried esterification method was used to prepare modified amphiphilic starches using 3, 6, or 9 % (w/v) octenyl succinic anhydride (OSA) and characterized through degree of substitution (DS), contact angle, particle size, scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and in-vitro digestibility. Moreover, Pickering emulsions were formulated using CWCS-OSA at 3 %, 6 %, or 9 % concentrations to serve as a carrier for curcumin to improve its water solubility and storage stability.

Cellulose nanofiber-reinforced antimicrobial and antioxidant multifunctional hydrogel with self-healing, adhesion for enhanced wound healing.

Current conventional wound dressings used for wound healing are often characterized by restricted bioactivity and devoid of multifunctionality resulting in suboptimal treatment and prolonged healing. Despite recent advances, the simultaneous incorporation of excellent flexibility, good mechanical performance, self-healing, bioactivity, and adhesion properties into the dressings without complicating their efficacy while maintaining simple synthesis remains a grand challenge. Herein, we effectively synthesized hybrid hydrogels of cellulose nanofiber (CNF), polyvinyl alcohol (PVA), and curcumin-modified silver nanoparticles (cAg) through a one-step synthesis method based on hydrogen bonds, dynamic boronic ester bonds, and coordinate covalent bonds.

Mechanism of photoluminescence properties of lyocell fibers changing with crystallinity.

Although there have been sporadic reports that the crystallinity of cellulose has a significant impact on photoluminescence (PL) properties, the degree and pattern of this effect have not been thoroughly explored and elucidated. Here, we assume that crystallinity is positively correlated with PL emission. Then, lyocell fiber (CLY), a common man-made cellulose fiber, is selected to solve the above problems by exploring the PL emission properties of different crystallinity systems.

Review on bioproduction of sialylated human milk oligosaccharides: Synthesis methods, physiologic functions, and applications.

Human milk oligosaccharides (HMOs) are crucial for promoting neonatal health, with sialylated oligosaccharides, a significant subclass, offering a variety of health benefits such as prebiotic effects, anti-inflammatory and antimicrobial properties, antiviral defense, and cognitive development support. Among these, 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL) have received "GRAS" status from the U.S.

A shear-responsive and lubricating hyaluronic acid-chondroitin sulfate-decellularized matrix hydrogel for articular cartilage regeneration.

The high-dynamic, high-loading environment in the joint cavity puts urgent demands on the cartilage regenerative materials with shear responsiveness and lubrication. Here, a new type of injectable hydrogel composed of oxidized hyaluronic acid (OHA), adipic dihydrazide-grafted hyaluronic acid (HA-ADH), oxidized chondroitin sulfate (OChs), and decellularized extracellular matrix methacrylate (dECMMA) was fabricated. The aldehyde groups in OHA and OChs reacted with the amino groups in HA-ADH to form a dynamic hydrogel, which was then covalently crosslinked with dECMMA to create a dual-crosslinked hydrogel with sufficient mechanical strength.

Cellulose-based hydrogel simultaneously possessing solar and evaporative cooling performances for energy-saving window and personal thermal management.

Thermochromic smart windows have been widely developed for building energy saving. However, most smart windows suffer from limited energy-saving performance, fixed phase transition temperature, and are not suitable for the temperature regulation needs of different application scenarios. Herein, a unique self-adaptive thermochromic hydrogel (HBPEC-PNA) with self-moisture-absorbing performance is reported that assembles solar energy cooling and evaporative heat dissipation.

Cellulose/sodium alginate gel electrolyte membranes with synergistic hydrogen bonding and metal ion coordination networks for high performance aqueous zinc-ion batteries.

Cellulose has outstanding potential for application in energy storage batteries due to its high temperature resistance, high electrolyte affinity, renewability, and suppression of the shuttle effect, but single cellulose membranes still suffer from problems such as inhomogeneous pore distribution and unstable three-dimensional network structure. In this study, a green and sustainable regenerative cellulose (RC)/sodium alginate (SA) gel electrolyte membrane is developed by sol-gel process, the double crosslinked network scaffold centered on Zn was constructed by the synergistic hydrogen-bonding and metal ion- coordination network, the stable and uniform pore structure was also formed. The obtained RC-SA gel electrolyte membrane exhibits outstanding performance, featuring a dual crosslinked network with abundant pore structure and numerous polar groups that effectively enhance Zn transport, significantly improving battery cycling performance.