Altered gray matter structural covariance networks in young adults with obesity.

Background: Overwhelming evidence showed that obesity was associated with abnormal brain functional networks. However, the changes of structural covariance networks (SCNs) based on cortical thickness (CT) and cortical surface area (CSA) in obesity is still unclear.

Methods: In this study, 243 young adults with obesity and matched 243 lean individuals were enrolled from the Human Connectome Project Release S1200 dataset.

How Health Anxiety is Associated with Perceived Risk of Reinfection Among COVID-19 Infected People After the Epidemic Control Measures Lifted in China: A Multiple Mediating and Multi-Group Analysis.

Background: After the lifting of epidemic control measures in China at the end of 2022, the number of COVID-19 infections has increased dramatically. Such an upsurge may intensify people's health anxiety and raise concerns about the risk of reinfection. While numerous studies have shown the correlation between them during the COVID-19, research on their underlying mechanism remains limited.

Adverse event profile of lorazepam: a real-world pharmacovigilance study using the FDA adverse event reporting system database.

Introduction: Anxiety diagnoses have surged recently during and after the COVID-19 pandemic. Lorazepam is widely recognized for its efficacy in treatment of anxiety, as well as insomnia, etc. However, the long-term safety profile of lorazepam in extensive patient populations has not been thoroughly established.

Berberine modulates microglial polarization by activating TYROBP in Alzheimer's disease.

Background: Characterized by β-amyloid (Aβ) plaques, neurofibrillary tangles, and aberrant neuroinflammation in the brain, Alzheimer's disease (AD) is the most common neurodegenerative disease. Microglial polarization is a subtle mechanism which maintains immunological homeostasis and has emerged as a putative therapeutic to combat AD. Berberine (BBR) is a natural alkaloid compound with multiple pharmacological effects, and has shown considerable therapeutic potential against inflammatory disorders.