Pharmacological mechanism of mylabris in the treatment of leukemia based on bioinformatics and systematic pharmacology.

Leukemia is a common blood cancer, whose treatment usually necessitates chemo/radiotherapy and bone marrow transplant. Hence, safer and more effective options are urgently needed. Mylabris, the dried body of blister beetles, has been used extensively in traditional Chinese medicine.

Chinese College Students' Stress and Anxiety Levels Under COVID-19.

The outbreak of COVID-19 at the end of 2019 has had a significant impact on people. While attention is paid to the immense physical harm it has caused, the psychological impact should not be underestimated. The main purpose of this study was to explore the stress, anxiety, and depression levels of different groups of college students during the COVID-19 pandemic.

Protective Effect of Raf-1 Kinase Inhibitory Protein on Diabetic Retinal Neurodegeneration through P38-MAPK Pathway.

Purpose: This study aimed to investigate the effect of Raf-1 kinase inhibitory protein (RKIP) on diabetic retinal neurodegeneration in streptozotocin-treated rat model and high glucose-treated rat Müller cells.

Methods: Control and streptozotocin-treated rats were intravitreally injected with saline, RKIP gene overexpression lentivirus (oeRKIP) or negative control lentivirus (RKIP-vector). Normal or high glucose-treated Müller cells were transfected with saline, RKIP gene overexpression lentivirus or negative control lentivirus.

Metabolomic modulations in a freshwater microbial community exposed to the fungicide azoxystrobin.

An effective broad-spectrum fungicide, azoxystrobin (AZ), has been widely detected in aquatic ecosystems, potentially affecting the growth of aquatic microorganisms. In the present study, the eukaryotic alga Monoraphidium sp. and the cyanobacterium Pseudanabaena sp.

A Novel Optimization Model and Application of Optimal Formula Design for CuCoFeO Spinel-Based Coating Slurry in Relation to Near and Middle Infrared Radiation Strengthening.

Coating slurry, in which the infrared radiation material is the main content, is applied in industrial furnaces to improve heat transfer and raise efficiency of furnaces. In this study, a CuCoFeO series material with a spinel structure was prepared, and the emissivity of different formulas in two wavebands (3-5 μm and 8-14 μm) was measured. To ensure that the material delivered high emissivity, optimization models were proposed using Matlab software, and proportions of CuO, CoO and FeO were found to be 16.

Edible plant Jiaosu: manufacturing, bioactive compounds, potential health benefits, and safety aspects.

Edible plant Jiaosu (EPJ), a type of plant-based functional food fermented by beneficial bacteria, has gained publicity in recent years for its potential benefits to health. Important progress in relevant manufacturing technology has been made in the past decade with respect to raw materials, fermentation microorganisms and fermentation conditions. Current research has revealed that EPJ contains abundant nutrients and bioactive compounds, such as minerals, amino acids, polyphenols, organic acids and polysaccharides.

Dynamic performances of a bird-like flapping wing robot under randomly uncertain disturbances.

The nonlinear dynamics of a bird-like flapping wing robot under randomly uncertain disturbances was studied in this study. The bird-like flapping wing robot was first simplified into a two-rod model with a spring connection. Then, the dynamic model of the robot under randomly uncertain disturbances was established according to the principle of moment equilibrium, and the disturbances were modeled in the form of bounded noise.

Indentation Size Effect in Pressure-Sensitive Polymer Based on A Criterion for Description of Yield Differential Effects and Shear Transformation-Mediated Plasticity.

Indentation size effects in poly(methyl methacrylate) (PMMA) were studied through nanoindentation. Two factors of indentation size effects in PMMA, namely yield criterion and shear transformation-mediated plasticity, were analysed in detail. The yield criterion that considers strength differential (SD) effects and pressure sensitivity was constructed by performing the combined shear-compression experiments.

Efficient Fractionation of Graphene Oxide Based on Reversible Adsorption of Polymer and Size-Dependent Sodium Ion Storage.

Graphene oxide (GO) is not only a unique class of two-dimensional (2D) materials but also an important precursor for scalable preparation of graphene. The efficient size fractionation of GO is of great importance to the fundamental and applied studies of chemically modified graphene, but remains a great challenge. Herein, we report an efficient and scalable fractionation method of GO employing reversible adsorption/desorption of temperature-responsive poly( N-isopropylacrylamide) on GO to amplify its mass difference and significantly improve the fractionation efficiency.

Forming Quality Analysis on the Cold Roll Forming C-channel Steel.

Cold roll forming, as a metal plastic forming process, is still mainly used in industrial production by the trial-and-error method, which wastes a lot of time and materials. In this paper, the C-channel steel is taken as the research object. First, the empirical equations of forming passes are verified and analyzed, then the cold roll forming model of C-channel steel is established, the forming quality of each pass and the stress-strain distribution of the whole sheet metal are analyzed, and the validity of the model is verified by experiments.

Super-high photocatalytic activity, stability and improved photocatalytic mechanism of monodisperse AgBr doped with In.

Monodisperse In(3+) doped AgBr (In-AgBr) nanoparticles were synthesized by a hydrothermal route. The pure AgBr and In-AgBr samples were investigated by X-ray powder diffraction, transmission electron microscopy, ultraviolet-visible absorption spectroscopy, X-ray photoelectron spectroscopy, measurement of total organic carbon, and electron paramagnetic resonance spectrometry. In-AgBr was more photocatalytically active than pure AgBr in photodegradation of 20 mg/L methyl orange under visible light irradiation (λ>420 nm).

Co(II)-grafted Ag3PO4 photocatalysts with unexpected photocatalytic ability: Enhanced photogenerated charge separation efficiency, photocatalytic mechanism and activity.

Since the photocatalytic capability is determined by the separation and transmission efficiency of photoinduced charges, its improvement remains a challenge for development of efficient photocatalysts. Here, we made large improvement on the surface of Ag3PO4 using Co(II)-grafted Ag3PO4 by a hydrothermal method. During the photocatalytic process, Co(II) was oxidized to Co(III) by the photogenerated holes under visible light radiation, which enhanced the separation efficiency of photogenerated charges.

Generalized models for rock joint surface shapes.

Generalized models of joint surface shapes are the foundation for mechanism studies on the mechanical effects of rock joint surface shapes. Based on extensive field investigations of rock joint surface shapes, generalized models for three level shapes named macroscopic outline, surface undulating shape, and microcosmic roughness were established through statistical analyses of 20,078 rock joint surface profiles. The relative amplitude of profile curves was used as a borderline for the division of different level shapes.