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A-to-I-edited miR-1251-5p restrains tumor growth and metastasis in lung adenocarcinoma through regulating TCF7-mediated Wnt signaling pathway.
Discov Oncol
October 2024
Zhejiang Hospital of Integrated Tradition Chinese and Western Medicine, Hangzhou, 310000, China.
Article Synopsis
- RNA editing from A to I, facilitated by ADARs, plays a crucial role in post-transcriptional processing, particularly in lung adenocarcinoma (LUAD) via the regulation of miR-1251-5p.
- Experiments using various methods like RT-qPCR and animal assays indicated that edited miR-1251-5p significantly inhibits tumor growth and metastasis compared to its unedited form.
- The edited miR-1251-5p achieves its anti-cancer effects by inactivating the Wnt signaling pathway through the suppression of genes like TCF7, MYC, and CCND1.