Clinicopathological features of non-carcinoid malignant epithelial appendix tumors and risk factors for recurrence, single-center experience.

Background: Non-carcinoid appendix epithelial tumors are rare. These tumors include low-grade and high-grade mucinous neoplasm also adenocarcinomas. We aimed to investigate the clinicopathological features, treatment, and risk factors of recurrence.

Could 25-OH vitamin D deficiency be a reason for HPV infection persistence in cervical premalignant lesions?

Vitamin D is an essential precursor to the steroid hormone calcitriol which mainly regulates calcium homeostasis. Moreover anti- proliferative, pro- apoptotic, anti- angiogenic effects of Vitamin D support the ideas of preventive role in various cancer. This study aimed to determine if there is a relationship between HPVDNA infection and cervical intraepithelial neoplasia and Vitamin D deficiency.

Uterine adenosarcomas: A dual-institution experience.

There has been limited literature about treatment and follow-up strategies of uterine adenosarcomas because of their rare nature. For this study we retrospectively investigated the medical database of the two major womens' health hospitals in Turkey. A total of 15 patients were identified from the hospital's database.

Prognostic value of 18F-FDG PET/CT for identifying high- and low-risk endometrial cancer patients.

Objectives: To assess the usefulness of adding PET/CT as a preoperative test for determining the extent of endometrial cancer and discriminating low- and high-risk patients to identify candidates for surgical staging.

Material And Methods: We retrospectively reviewed 86 patients with pathologically proven endometrial cancer who had undergone preoperative ¹⁸F-FDG PET/CT. The prognostic relationships between PET/CT parameters and pathology reports were assessed.

Efficacy of a real time optoelectronic device (TruScreen™) in detecting cervical intraepithelial pathologies: a prospective observational study.

Objective: To assess the effect of TruScreen™ (an objective optoelectronic cervical screening device) in improving the sensitivity of cervical screening programs either alone or in combination with Papanicolaou (PAP) smear or human papilloma virus (HPV) DNA screening.

Material And Methods: Our study was performed in 285 patients with abnormal Pap test results. TruScreen™ and HPV screening methods were performed in all participants.

A prospective randomized trial of postoperative pain following different insufflation pressures during gynecologic laparoscopy.

Objective: To determine the effects of different intra-abdominal pressure values on visceral pain following gynecologic laparoscopic surgery in the Trendelenburg position.

Study Design: This randomized, controlled prospective trial was conducted at a tertiary education hospital and included 150 patients who underwent gynecologic laparoscopy with different abdominal insufflation pressures. There were 54 patients in the 8 mmHg low pressure group (LPG), 45 in the 12 mmHg standard pressure group (SPG), and 51 in the 15 mmHg high pressure group (HPG).

Decreased placental thickness and impaired Doppler indices in idiopathic polyhydramnios: a prospective case-control study.

Objective: To evaluate placental thickness, Doppler velocimetry, biophysical profile and perinatal outcomes in pregnancies complicated by idiopathic polyhydramnios.

Materials And Methods: This prospective case-control study was conducted on 139 pregnant women, of these 70 patients with idiopathic polyhydramnios comprised the study group and 60 pregnant women comprised the control group. Risk factors recorded were; age, parity, body mass index (BMI), gestational weeks, amniotic fluid index (AFI), biophysical profiles (BPP), placental thickness, middle cerebral artery pulsatility index (MCA PI), umbilical artery Doppler velocimetry (Umb A S/D) values and perinatal outcomes.

The relationship between third trimester maternal hemoglobin and birth weight/length; results from the tertiary center in Turkey.

Objective: The aim of this study was to investigate the relationship between third trimester maternal hemoglobin values and fetal birth weight/length.

Methods: Retrospective study was conducted on 28600 Turkish pregnant women who delivered between January 2010 and December 2011. Hemoglobin values at third trimester, all birth weights/lengths of newborns were retrospectively analyzed.

The effect of diet on pregnancy outcomes among pregnant with abnormal glucose challenge test.

Objectives: Gestational diabetes mellitus (GDM) is defined as glucose intolerance, first time detected in pregnancy. Diagnostic criteria for GDM have changed over the decades. The aim of the study was to examine the effect of diet on birth weight, number of large for gestational age (LGA) (birth weight > 90th percentile) babies, total maternal weight gain, gestational age and route of delivery among patients with positive 50 g glucose challenge test (GCT) and negative 100 g oral glucose tolerance test (OGTT).

Serum brain natriuretic peptide and C-reactive protein levels in adolescent with polycystic ovary syndrome.

Objective: Our primary aim was to investigate whether N-terminal pro-brain natriuretic peptide (NT-proBNP) increases in adolescent with polycystic ovary syndrome (PCOS) compared with healthy controls and secondary aim was to determine whether metabolic and hormonal differences exist between groups.

Methods: In this cross-sectional study, 25 adolescent patients with PCOS and 25 normal ovulatory control not suffering from PCOS were involved in the study. Fasting serum NT-proBNP, C-reactive protein (CRP), homocystein, insulin levels and biochemical and hormonal parameters were measured.

Histopathological analysis of the placental lesions in pregnancies complicated with IUGR and stillbirths in comparison with noncomplicated pregnancies.

Objective: Placental factors and hypoxemia are the keys to intrauterine growth restriction (IUGR) and stillbirth. The aim of the study is to analyze histological changes in placentas of IUGR fetuses in pregnancies with no apparent etiologic factor and unexplained intrauterine fetal deaths.

Material And Methods: A total of 110 placentas were collected; 26 placentas of IUGR fetuses with no apparent cause, 58 placentas from unexplained intrauterine deaths over 20 weeks of gestation, and 26 placentas from uncomplicated pregnancies who delivered a healthy live baby.

Superior ovarian nerve (SON) transection leads to stunted follicular maturation: a histomorphologic and morphometric analysis in the rat model.

Histomorphologic and morphometric effects of peripubertal superior ovarian nerve (SON) transection were evaluated during adult life in rats. Twenty Sprague-Dawley rats were randomly divided into two groups: the SON-transected (SON-t) group (n = 10) and the sham-operated control group (n = 10). Total follicle development was not influenced; however, follicular maturation was seriously stunted by the procedure, as evidenced by significantly thinner theca interna and follicular wall.

Does hysterectomy affect ovarian function? Histopathologic evaluation and serum FSH, inhibin A, and inhibin B levels in an experimental rat model.

Objective: To evaluate the effects of hysterectomy with ovarian conservation on ovarian histology, and FSH, inhibin A, and inhibin B plasma levels.

Study Design: Forty-five female Wistar albino rats were used in this study and randomly divided into two groups: hysterectomy (n=30) and sham-operated (n=15). Blood samples were collected before and after (50 and 100 days) abdominal hysterectomy from both groups to measure plasma levels of FSH, inhibin A, and inhibin B.

The role of thrombocytosis in prognostic evaluation of epithelial ovarian tumors.

Background: Thrombocytosis has been reported in a variety of solid tumors, including certain gynecologic cancers such as endometrial, vulvar, and cervical cancers. The present study aims to determine the incidence of thrombocytosis in women with epithelial ovarian tumors and to evaluate its association with clinical and pathologic prognostic factors.

Material And Methods: Between January 2001 and December 2006, 292 patients were diagnosed with epithelial ovarian tumors, and they underwent primary surgical treatment and subsequent platinum-based chemotherapy at the Gynecologic Oncology Department of the study center.

The evaluation of endometrial tumors by transvaginal and Doppler ultrasonography.

Background: Endometrial cancer is the most common malignancy of the female genital tractus which is primarily seen in postmenopausal women. The purpose of this study is to investigate the relation between uterine histopathologic alterations and sonographic findings in women diagnosed with endometrial cancer.

Materials And Methods: A total of 120 women who were histologically diagnosed with endometrial cancer and who admitted to Gynecologic Oncology Department in the study center were eligible.

The effects of TCu-380A on cervicovaginal flora.

Objective: This study aims to identify the alterations in cervicovaginal flora after insertion of TCu 380A which is a popular type of copper IUD.

Study Design: Among the women who visited the Department of Family Planning in our hospital during 1 month, 100 subjects who preferred IUDs for contraception and who had no history of local or systemic antibiotic use were considered eligible candidates.

Results: Anaerobic colonies, especially Gram-positive cocci and Gram-negative bacilli were isolated at significantly higher rates after the insertion of TCu-380A.

Predictive value of maternal serum and vaginal interleukin-6 levels in preterm labor.

Objective: The aim of the current study was to evaluate the predictive value of maternal serum and vaginal interleukin 6 (IL-6) levels for preterm delivery before 37 gestational weeks in patients with preterm labor and to determine the probable relationship between IL-6 concentrations and delivery interval.

Methods: In this prospective study, maternal serum and vaginal IL-6 levels were measured in 40 patients with the diagnosis of preterm labor between the 28th and 36th gestational weeks (study group) and in 20 pregnant women between the same gestational weeks attending the antenatal clinic with no complaints (control group). The gestational age at the time of admission and delivery, as well as the delivery interval, were evaluated and compared with the concentration of IL-6 on admission.

Myomectomy during cesarean section.

Objective: To evaluate the outcome of myomectomy during cesarean section and to compare it with a control group.

Materials And Methods: Using a retrospective case-control design; 40 patients who underwent myomectomy at time of cesarean delivery were compared with the control group consisted of 80 patients with myomas who underwent cesarean delivery alone.

Results: The mean size of fibroids removed was 8.

Doppler study of myometrium in invasive gestational trophoblastic disease.

Objective: In this prospective study, we aimed to assess the prognostic and diagnostic role of color Doppler flow of myometrium in patients with invasive gestational trophoblastic disease (GTD).

Methods: Thirty-seven patients, who were enrolled in the study with invasive mole, were assessed with the help of transvaginal color Doppler ultrasound before and after chemotherapy. The place and the size of the myometrial invasions were assessed.

Clinical outcomes of early postplacental insertion of intrauterine contraceptive devices.

Objectives: To assess the efficacy, safety and, thus, advantages and disadvantages, of early postplacental intrauterine device (IUD) insertion.

Methods: IUDs were inserted within 10 min after postplacental expulsion in term pregnancy both in vaginal and cesarean deliveries via a ring forceps. Of the 276 patients enrolled, 235 were included in the study.