Combination Effect of Phenylalanine-Arginine-Beta-Naphthylamide and Curcumin on the Expression of the Gene in Aminoglycoside-Resistant Clinical Isolates of .

Background And Aims: Overexpression of MexXY-OprM efflux pump causes resistance to aminoglycosides in . We aimed to investigate the relationship between resistance to aminoglycosides and the MexXY-OprM expression level in clinical isolates without and after treatment with curcumin and/or phenylalanine-arginine-beta-naphthylamide (PAβN) as the efflux pump inhibitors.

Methods: We collected 100 clinical isolates from hospitalized patients.

Curcumin mitigates acrylamide-induced ovarian antioxidant disruption and apoptosis in female Balb/c mice: A comprehensive study on gene and protein expressions.

Curcumin is known for its antioxidant properties. This study aimed to investigate the impact of curcumin on acrylamide (ACR)-induced alterations in the first-line antioxidant defense of ovarian tissue. Female Balb/c mice were divided into control, ACR (50 mg/kg), ACR/CUR100 (received Acr + curcumin100 mg/kg), and ACR/CUR200 (Acr + curcumin 200 mg/kg) groups, and received oral treatments for 35 days.

Antimicrobial combination effects against multidrug-resistant and strains: A cross-sectional study.

Background And Aims: Emergence of multidrug resistance in non-fermenting Gram-negative bacilli is a threat to public health. Combination therapy is a strategy for the treatment of antibiotic-resistant infections.

Methods: In this cross-sectional study, a total of 63 nonduplicate clinical isolates of and  were collected from various specimens.

Characteristics, antimicrobial capacity, and antioxidant potential of electrospun zein/polyvinyl alcohol nanofibers containing thymoquinone and electrosprayed resveratrol nanoparticles.

The aim of the present study was to fabricate, characterize, and evaluate the in vitro antimicrobial and antioxidant properties of zein/polyvinyl alcohol (ZN/PVA) nanofibers containing 2% and 4% of thymoquinone (TQ), either alone or in combination with electrosprayed ZN nanoparticles containing 1% and 2% of resveratrol (RS). According to scanning electron microscopy analysis, the diameter of nanofibers and nanoparticles increased with increasing TQ and RS concentrations, respectively. The molecular interaction between ZN or PVA polymers and TQ or RS was confirmed by Fourier transform infrared spectroscopy.

Oral manifestation as the only sign of Langerhans cell histiocytosis: A case report.

Key Clinical Message: The manifestations of Langerhans cell histiocytosis can be limited in the oral cavity, including gingival recession, tooth mobility, and bone destruction. Dentists play a crucial role in the early detection and management of these oral symptoms, which can significantly impact the overall prognosis and quality of life for patients with this serious disease.

Abstract: The hyperplastic activity of bone marrow can lead to excessive histocyte proliferation, called Langerhans cell histiocytosis (LCH).

Impact of sodium alginate-based film loaded with resveratrol and thymol on the shelf life of cooked sausage and the inoculated .

In present study, sodium alginate biodegradable films containing different concentrations of resveratrol (RES: 0.002% and 0.004%) or thymol (THY: 0.

Left ventricular thrombus formation in a COVID-19 patient with a complex course of pericarditis and myocardial infarction.

Our case demonstrated that thrombotic complications such as coronary thrombosis and left ventricular clot could occur even in coronavirus disease 2019 (COVID-19) patients with nonspecific symptoms which indicates the mysterious face of COVID-19. This complex process highlights the necessity of screening patients for COVID-19 disease even with nonspecific cardiac symptoms.

Epinecidin-1 (an active marine antimicrobial peptide): Effects on the survival of inoculated O157:H7 And bacteria, antioxidant, and sensory attributes in raw milk.

This study aimed to evaluate the effects of Epinecidin-1 (Epi-1) on total viable count (TVC), total psychrotrophic count (TPC), sensory attributes, and the survival of O157:H7 and bacteria inoculated in pasteurized milk samples during cold storage (4°C). Four treatments of milk samples were prepared including milk samples containing three concentrations of Epi-1 (0.0025, 0.

The synthesis and development of poly(ε-caprolactone) conjugated polyoxyethylene sorbitan oleate-based micelles for curcumin drug release: an study on breast cancer cells.

Background: it is now known that curcumin (Cur) has a broad range of biological properties; however, photosensitivity, as well as low bioavailability and short half-life, have limited its clinical application. To overcome these problems the synthesis of poly(ε-caprolactone)-Tween 80 (PCL-T) copolymers was performed.

Methods: the copolymers of PCL-T were created using the solvent evaporation/extraction technique.

Muscular and hepatosplenic candidiasis in a patient with acute myeloblastic leukemia: A case report and literature review.

Key Clinical Message: Muscular and subcutaneous candidiasis is a rare entity in immunocompromised patients, but it should be kept in mind when we see multiple cystic soft tissue masses in addition to target-shaped hepatosplenic lesions in neutropenic patients. US and MRI are useful imaging modalities for the diagnosis and follow-up of these patients.

Abstract: Soft tissue candidiasis is an opportunistic infection in immunocompromised patients and must always be diagnosed and treated as soon as possible.

Mycoprotein as chicken meat substitute in nugget formulation: Physicochemical and sensorial characterization.

The aim of this study was to replace chicken breast by mycoprotein in nuggets and optimizing the sensory and technological properties. In the first step of the study, 14 formulations were prepared by mixture design to evaluate the impact of three binding agents (as independent variables): soy protein isolate, phosphate, and carrageenan on sensory properties. Then, the optimized formulation of mycoprotein nugget (with higher acceptability) was characterized and compared to chicken nugget (control) from texture, color, and physicochemical aspects.

Identification of a novel pathogenic variant in in an Iranian family with long QT syndrome 2 by whole-exome sequencing.

Background: Long QT syndrome (LQTS) is a lethal cardiac condition. However, the clinical implementation of genetic testing has now made LQTS eminently treatable. Next-generation sequencing has remarkable potential for both clinical diagnostics and research of LQTS.

Effect of CDH1 and CDH2 genes polymorphisms in oral squamous cell carcinoma susceptibility in a sample of Iranian population: A case-control study.

Background And Aims: Oral squamous cell carcinoma (OSCC) is a global malignant epithelial neoplasm affecting the oral cavity. Cadherins, as an adhesion molecule, are involved in cell-cell interaction. We aim to study the effect of two cadherin polymorphisms on OSCC risk in southeast of Iran.

Preventing pressure injury in open-heart surgical patients: A systematic review.

Background: Cardiac surgical patients are highly prone to developing surgery-related Pressure injuries (PIs). Prevention of PIs is an important patient safety priority in healthcare settings and patients care. So the aim of this study is to detect the effectiveness of prevention strategies to decrease PIs prevalence and incidence in patients undergoing open heart surgery.

Non-contiguous multilevel spinal tuberculosis: A case report of unusual spinal tuberculosis resembling spinal metastasis.

Spinal tuberculosis (TB) is diagnostically challenging, particularly in atypical forms. Non-contiguous multilevel spinal TB (NMLST) is a rare presentation of spinal TB, mimicking spinal malignancies. We reported an unusual NMLST case with a paraspinal and epidural abscess in a young patient with misleading clinical and imaging presentations.

Venous thromboembolism in viral diseases: A comprehensive literature review.

Venous thromboembolism (VTE) is known to be a common respiratory and/or cardiovascular complication in hospitalized patients with viral infections. Numerous studies have proven human immunodeficiency virus infection to be a prothrombotic condition. An elevated VTE risk has been observed in critically ill H1N1 influenza patients.

miRNA-encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers.

MicroRNAs (miRNAs) as therapeutic agents have attracted increasing interest in the past decade owing to their significant effectiveness in treating a wide array of ailments. These polymerases II-derived noncoding RNAs act through post-transcriptional controlling of different proteins and their allied pathways. Like other areas of medicine, researchers have utilized miRNAs for managing acute and chronic wounds.

Effect of heating on disposal point of main edible oils available in Iran market.

Deep frying is the most common method used for food preparation worldwide, which can lead to several chemical changes in used fat or oil in frying process including oxidation and polymerization. This study aimed to determine the effect of heating and different storage conditions on the disposal point of four types of the most common edible oils available in the Iranian market without and with the presence of food in terms of acid value (AV) and total polar compounds (TPC). AV and TPC of three types of marketed sunflower oil (especially for frying, cooking, solid vegetable) and ghee heated at 110, 150, 180, and 200°C with a portable oil meter DOM-24 (ATAGO, Japan) were determined.

Cancer patients and targeted therapy during COVID-19 pandemic: A descriptive case series study.

To evaluate the effectiveness of targeted therapy on preventing or treating COVID-19, in this study, we want to share our experience about 14 patients (nine women, five men; average age, 59 years) who were treated with targeted therapy due to their underlying malignant disorders in our center.

Impact of microencapsulated essential oil and orange fiber as natural-functional additives on chemical and microbial qualities of cooked beef sausage.

The aim of the current study was to investigate the suitability of essential oil (ZEO) as a preservative. For this purpose, the effect of free and microencapsulated ZEO, combined with orange fiber, was determined on the chemical and microbial qualities of cooked beef sausage. In this study, modified starch was used for encapsulation of essential oil, and subsequently, 0.

Awareness, attitude, and perceived anxiety about COVID-19 in the Iranian population: A cross-sectional questionnaire survey.

An emergence of mental health issues among the general population has been reported during the COVID-19 pandemic. This study aimed to estimate COVID-19 awareness, attitude, and perceived anxiety among the Iranian people. This is a cross-sectional web-based survey done on the community population of Iran.

Isthmocele-a neglected cause of secondary infertility and implantation failure: A case report.

Isthmocele is myometrial scar tissue that develops after cesarean section delivery. In this case, other more prevalent pathologies delayed isthmocele diagnosis as the main cause of the patient's symptoms. Considering isthmocele is a fluid-filled pouch-like defect associated with infection caused by stagnant menstrual blood, its immunological aspects lead to implantation failure.

The first report of 2:1 atrioventricular block following COVID-19 vaccination.

A 65-year-old man became ill a few days after being vaccinated against the COVID-19 by the Sinopharm vaccine. Laboratory investigations, trans-thoracic echocardiography, and chest computed tomography scanning (CT-scan) retrieved normal results. The patient's electrocardiogram showed sinus rhythms with 2:1 AV-block and a narrow QRS complex.

Successful approach for couples having their own genetic offspring using vitrified-warmed oocytes injected by frozen-thawed poor quality testicular sperm: A case report.

The clinical applications of donated gametes are approved in many countries; however, attitudes toward its application and national legislation in some countries are challenging. The purpose of this study is to report a healthy live birth produced by vitrified-warmed oocytes and frozen-thawed testicular sperms to avoid sperm donation.

Evaluation of antioxidant and antibacterial interactions between resveratrol and eugenol in carboxymethyl cellulose biodegradable film.

The aim of present study was to compare the in vitro antioxidant and antibacterial properties of carboxymethyl cellulose (CMC) films containing resveratrol (RES) and eugenol (EUG), alone and in combination, and to calculate the dose interactions between them. At first, the total phenolic content of CMC films was evaluated. Then, their antioxidant and antibacterial effects of films were determined using DPPH, reducing power, disk diffusion, and broth dilution methods.