The immune cells profiles of individuals with sulfur mustard-induced serious long-term respiratory complications.

Sulfur mustard (SM) induced pulmonary disorder is a heterogeneous disease characterized by uncontrolled inflammatory immune responses. In this cross-sectional study carried out in Isfahan-Iran, our objective was to thoroughly evaluate the clinical health and peripheral blood leukocyte profiles of adult veterans exposed to SM 25-30 years. In total, 361 people were studied in two groups, 287 chemical veterans with pulmonary complications and 64 healthy individuals as a control group.

Exploring the reasons for self-administration medication errors among illiterate and low-literate community-dwelling older adults with polypharmacy: a qualitative study.

Background: Polypharmacy and low literacy increase medication self-administration errors (MSEs) among older adults, adversely affecting both patients and healthcare systems through increased costs and reduced treatment efficacy.

Objectives: This study explored the reasons for MSEs among illiterate and low-literate older adults with polypharmacy from the perspective of older adults, informal family caregivers, physicians, and pharmacists.

Method: The qualitative study used a conventional content analysis approach from September 2022 to April 2023.

Investigating the relationship between diet quality, lifestyle and healthy eating index with severity and migraine attacks: a cross-sectional study.

Background: Migraine is a disabling neurovascular disorder often associated with comorbidities such as mental health disorders, cardiovascular diseases, and metabolic syndromes. While certain dietary triggers have been identified, the impact of overall diet quality on migraine severity and frequency is not well understood. This study aimed to evaluate the association between diet quality, lifestyle factors, and the Healthy Eating Index (HEI) with migraine severity and frequency.

Combination of methanolic-extract with cisplatin can induce antioxidant activity and apoptosis in HeLa and Caski cells.

Background: Cisplatin-based chemotherapy as a common therapeutic regimen for cervical cancer patients, is becoming more and more ineffective due to high resistance. This urges the need for introducing novel metabolics such as botanical drugs with the capacity to increase the cisplatin effectiveness. In that regard, here we investigated the anticancer effects of the Cisplatin- combination in cervical cancer cell lines.

A maternal sweet diet is associated with the gut dysbiosis in the first trimester of pregnancy.

Background: The composition of maternal gut phylum in each trimester of pregnancy has been associated with fetal development, separately. Diet is a main effective factor on the gut composition of phylum. However, associations between dietary glycemic index (GI), load (GL) and total antioxidant capacity (TAC) not studied with the gut population of phylum in mothers at the first trimester of pregnancy.

The relationship between academic motivation and moral sensitivity in nursing students.

Background: A Bachelor's degree in nursing is one of the most challenging programs in the field of medical sciences. As a result, maintaining students' academic motivation at the desired level is a constant concern for policymakers and educational administrators. Furthermore, tackling complex ethical dilemmas is inherent in nursing, making the educational period an important moment to instill moral sensitivity and reinforce professional ethics in students.

Distinct inflammatory profiles in mustard lung: A study of sulfur mustard-exposed patients with serious pulmonary complications.

Mustard Lung (ML) refers to respiratory complications caused by sulfur mustard (SM) exposure, a chemical warfare agent. This study explores the inflammatory profile of SM-exposed veterans with serious ML, aiming to distinguish it from other respiratory diseases. The aim is also to comprehend the role of inflammatory markers in disease severity.

Long-Term Decision Regret and Associated Factors Following Urinary Reconstruction in Underserved Patients with Spinal Cord Injury.

Purpose: Patients with refractory neurogenic bladder dysfunction may require urinary reconstruction due to severe incontinence, difficulty with catheterization, and to prevent upper urinary tract compromise. We evaluated long-term decisional regret and associated factors following urinary reconstruction in spinal cord injury patients.

Materials And Methods: We interviewed patients with spinal cord injuries who underwent bladder reconstruction surgery at least ten years ago, administering validated surveys on bowel quality of life and dysfunction, urinary tract infections, and decisional regret.

Effect of selective and family-based prevention on addiction susceptibility, affiliation with deviant peers, risk-taking, and risk and protective factors of substance use in high-risk adolescents: A randomized clinical trial.

Background: Adolescents with a background in families affected by substance use exhibit an increased susceptibility to developing individual substance-related or other mental disorders. Consequently, they represent a crucial demographic for targeted preventive interventions. The current study examined the impact of selective prevention (SP) and family-based prevention (F-BP) measures on addiction susceptibility, affiliation with deviant peers (ADP), risk-taking, and risk and protective factors (RPFs) related to substance use among high-risk adolescents.

Glucantime and quercetin electrospun nanofiber membranes: Fabrication and their evaluation as dressing for cutaneous leishmaniasis.

Cutaneous leishmaniasis is considered as one of the most concerns of the World Health Organization (WHO). The main objective of this study was to use polycaprolactone (PCL) nanofiber scaffolds in order to provide a topical drug delivery system capable of delivering glucantime (glu) and quercetin (qur) to cutaneous leishmaniasis wounds. First, PCL/glu/qur, PCL/glu, and PCL/qur nanofibers were prepared by an electrospinning method followed by characterization through scanning electron microscopy (SEM) and fourier transform infrared spectroscopy (FTIR).

The application of aptamer in tuberculosis diagnosis: a systematic review.

Tuberculosis represents a significant menace to health, leading to millions of cases and fatalities each year. Traditional diagnostic methods, while effective, have limitations, necessitating improved tools. Aptamers possessing remarkable specificity single-stranded DNA or RNA molecules promising in TB diagnosis due to their adaptability and precise biomarker detection capabilities.

Correlation of IL-10 and IL18 with the development of liver cirrhosis associated with hepatitis B virus infection: A systematic review.

Background: Patients who have been infected with the Hepatitis B virus (HBV) are susceptible to developing liver cirrhosis (LC) and hepatocellular carcinoma (HCC). The objective of this systematic review was to comprehensively scrutinize the existing evidence concerning the association between host genetic polymorphisms and HBV-associated LC.

Methods: We searched databases of PubMed, Scopus, and Web of Science for relevant articles published from building databases to 25 October 2023.

Cold plasma technology: A cutting-edge approach for enhancing shrimp preservation.

Cold plasma (CP) is an emerging technology employed to safeguard highly perishable food items, particularly aquatic products such as shrimp. Due to its significant amount of moisture, superior protein composition that contains important amino acids, and unsaturated fatty acid content, shrimp are susceptible to microbial deterioration and overall alterations in their physical and chemical characteristics. Such spoilage not only diminishes the nutritional value of shrimp but also has the potential to generate harmful substances, rendering it unsuitable for consumption.

The effectiveness of group counselling based on positive psychology on the psychology capital of students with premenstrual syndrome: a randomized controlled clinical trial.

During menstruation, psychological capital (PsyCap) holds great potential for young women to manage and adapt to changes in their bodies and minds. This study aimed to investigate the effect of group counseling with a positive approach on the PsyCap of students with premenstrual syndrome (PMS). A randomized controlled clinical trial was conducted on 40 students with PMS in 2021.

Combination Effect of Phenylalanine-Arginine-Beta-Naphthylamide and Curcumin on the Expression of the Gene in Aminoglycoside-Resistant Clinical Isolates of .

Background And Aims: Overexpression of MexXY-OprM efflux pump causes resistance to aminoglycosides in . We aimed to investigate the relationship between resistance to aminoglycosides and the MexXY-OprM expression level in clinical isolates without and after treatment with curcumin and/or phenylalanine-arginine-beta-naphthylamide (PAβN) as the efflux pump inhibitors.

Methods: We collected 100 clinical isolates from hospitalized patients.

The Interplay Between Obesity and Aging in Breast Cancer and Regulatory Function of MicroRNAs in This Pathway.

Breast cancer (BC) is a significant contributor to cancer-related deaths in women, and it has complex connections with obesity and aging. This review explores the interaction between obesity and aging in relation to the development and progression of BC, focusing on the controlling role of microRNAs (miRNAs). Obesity, characterized by excess adipose tissue, contributes to a proinflammatory environment and metabolic dysregulation, which are important in tumor development.

Health assessment of sulfur mustard-chemical veterans with various respiratory diseases: The result of a comparative analysis of biological health scores (BHS) through 50 biomarkers.

Background: Mustard gas as a chemical weapon has been used in wars and its long-term side effects are substantial in the human body. This study aimed to apply an extension of allostatic load, known as biological health score (BHS), including the wear-and-tear of four physiological systems (endocrine, inflammatory, cardiovascular, and metabolic systems) to estimate biological health caused by sulfur mustard (SM) toxicity.

Methods: In this cross-sectional study, serum samples were collected from two distinct groups of male individuals including 1) 236 individuals who had been exposed to SM gas during the Iraq-Iran war in 1987.

Quercetin and calorie restriction improve leptin/adiponectin balance through reducing high-fat diet-induced oxidative stress in male BALB/c mice.

Throughout the recent decades, obesity has become a serious health problem that raises the risk of several diseases, including cancer, diabetes, hypertension, heart disease, neurological musculoskeletal disorders, and Non-alcoholic fatty liver disease. Some strategies, such as dietary interventions, calorie restriction (CR), and the use of antioxidant compounds, have been proposed to improve quality of life in relation to obesity. The goal of this study was to characterize the effects of CR and quercetin (QUER) on obesity-induced oxidative stress (OS).

Schema modes and social maladjustment: The mediating role of difficulty in emotion regulation.

Background: Studies show that emotion regulation as a special form of self-regulation and schema modes as the basis of different states of awareness affect the behavior and cognition of individuals, which can also affect social adjustment in the sense of establishing a balance between the needs of oneself and society. The present study was conducted to investigate the relationship between schema modes and social maladjustment with the mediation of difficulty in emotion regulation in students.

Method: The participants were 670 students from a medical university who were selected by convenient sampling.

Moral Distress Challenges in Nurses During Early Stage of COVID-19 Pandemic: A Qualitative Study.

Introduction: As a serious crisis, the COVID-19 pandemic put a lot of pressure on nurses, and many ethical challenges arose for them. The aim of the study was to explore the moral distress challenges in nurses during the COVID-19 pandemic.

Methods: A qualitative study with a conventional content analysis approach was adopted.