11,563 results match your criteria: "Zambia; University of Rochester School of Medicine[Affiliation]"

Background: Patients with chronic pain often experience psychological issues. They may also exhibit harassing behaviors toward healthcare staff. This complex sociomedical issue necessitates increased attention.

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Background: Despite several global interventions, tuberculosis (TB) remains a leading cause of death affecting millions of people globally. Many TB patients either have no access to quality care or go undetected by national health systems. Several multilevel factors account for under-detection of persons with TB.

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Prevalence of elephantiasis, an overlooked disease in Southern Africa: a comprehensive review.

J Venom Anim Toxins Incl Trop Dis

October 2024

Center of Infectious Diseases and Medicinal Plants, Department of Botany, Faculty of Science and Agriculture, University of Fort Hare, Alice, South Africa.

Article Synopsis
  • - Elephantiasis, also known as lymphatic filariasis (LF), affects around 120 million people globally and leads to severe physical deformities, impacting quality of life and socio-economic status, particularly in Southern Africa.
  • - LF is endemic in four Southern African Development Community (SADC) countries, with some regions facing challenges in mass drug administration (MDA) efforts, while Malawi has successfully eliminated LF as a public health problem.
  • - Gaps in knowledge about LF prevalence in the SADC region highlight the need for ongoing research, improved data collection, and effective policies to combat the disease and enhance healthcare infrastructure.
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Terra Preta production from Ghanaian and Zambian soils using domestic wastes.

Sci Rep

October 2024

Department of Soil Biogeochemistry, Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, von-Seckendorff-Platz 3, Halle (Saale), Germany.

Quests for productive soils to close yield gaps call for innovative strategies. This study tested an off-site formation of the Amazonian Terra Preta (TP) in a potential modern analogon under coastal savannah climatic conditions of Ghana. Four Ghanaian and two Zambian soils; two types of biochar (i.

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Urban public space initiatives and health in Africa: A mixed-methods systematic review.

PLOS Glob Public Health

October 2024

Global Diet and Activity Research Group and Network, MRC Epidemiology Unit, University of Cambridge, United Kingdom.

Article Synopsis
  • Public space initiatives (PSIs) in African cities can improve health and social well-being, but there's a lack of research on their effectiveness and implementation across the continent.
  • This study synthesizes existing literature to assess the characteristics, locations, and outcomes of PSIs, finding that sports initiatives are predominant and that most research comes from South Africa.
  • Key challenges for PSIs include limited funding, historical marginalization, and competing land uses, highlighting the need for long-term evaluations and better collaboration for sustainable health-promoting public spaces.
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Crowdsourcing strategies are useful in the development of public health interventions. Crowdsourcing engages end users in a co-creation process through challenge contests, designathons or online collaborations. Drawing on our experience of crowdsourcing in four African countries, we provide guidance on designing crowdsourcing strategies across seven steps: deciding on the type of crowdsourcing strategy, convening a steering committee, developing the content of the call for ideas, promotion, evaluation, recognizing finalists and sharing back ideas or implementing the solutions.

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Governments in low and middle-income countries (LMICs) are increasingly considering the introduction of national health insurance scheme (NHIS) as a strategy to achieve universal health coverage (UHC) targets. The literature has widely documented the technical challenges associated with implementing UHC policies in LMICs but much less is known about the political process necessary to pass UHC legislation. In this article, we document the political economy issues surrounding the establishment of the Zambia NHIS in 2018.

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Background: Some settings continue to experience a high malaria burden despite scale-up of malaria vector control to high levels of coverage. Characterisation of persistent malaria transmission in the presence of standard control measures, also termed residual malaria transmission, to understand where and when individuals are exposed to vector biting is critical to inform refinement of prevention and control strategies.

Methods: Secondary analysis was performed using data collected during a phase III cluster randomized trial of attractive targeted sugar bait stations in Western Province, Zambia.

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Despite the beneficial impacts of using drugs in animal husbandry, the risks of drug residues in animal products are a concern worldwide. Therefore, most countries have developed systems and methods to detect and monitor drug residues in animal products using high performance liquid chromatography (HPLC) with mass spectrometry (MS). However, MS detectors are not available in all universities; thus, we developed a new method suitable for ultraviolet detection.

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Investing in family planning and reproductive health—broadly defined as the services, policies, information, attitudes, practices, and commodities, including contraceptives, that help individuals achieve their fertility intentions—is integral to attaining many Sustainable Development Goals.

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Background: Addressing the challenge of cancer control requires a comprehensive, integrated, and global health-system response. We aimed to estimate global radiotherapy demands and requirements for radiotherapy professionals from 2022 to 2050.

Methods: We conducted a population-based study using data from the Global Cancer Observatory (GLOBOCAN) 2022 and predicted global radiotherapy demands and workforce requirements in 2050.

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Tuberculosis (TB) mortality remains a significant public health concern globally. This study aimed to determine the prevalence of tuberculosis-related deaths and associated factors among patients at Livingstone University Teaching Hospital (LUTH) Chest Clinic, Zambia. We conducted a retrospective cross-sectional study among 694 individuals (507 adult and 187 children) diagnosed with drug susceptible TB disease between January 1, 2021, and December 31, 2022.

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Introduction: Diarrhoeagenic Escherichia coli (DEC) persistently challenges public health in Africa, contributing substantially to the diarrhoeal disease burden. This systematic review and meta-analysis illuminate the distribution and antimicrobial resistance (AMR) patterns of DEC pathotypes across the continent.

Methods: The review selectively focused on pathotype-specific studies reporting prevalence and/or AMR of human-derived DEC pathotypes from African nations, excluding data from extra-intestinal, animal, and environmental sources and studies focused on drug and mechanism experiments.

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Background: Antimicrobial stewardship (AMS) programs are critical in combating antimicrobial resistance (AMR). In Zambia, there is little information regarding the capacity of hospitals to establish and implement AMS programs. The objective of this study was to conduct a baseline assessment of WHO core elements for an AMS program implementation in eight hospitals in Zambia.

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Genotype × environment interaction (GEI) poses a critical challenge to plant breeders by complicating the identification of stable variety (ies) for performance across diverse environments. GGE biplot and AMMI analyses have been identified as the most effective and appropriate statistical techniques for identifying stable and high-performing genotypes across diverse environments. The objective of this study was to identify widely adapted and high-yielding soybean genotypes from Multi-Locational Trials (MLTs) using GGE and AMMI biplot analyses.

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Article Synopsis
  • The study investigates how adolescent girls and young women in Kenya, Malawi, and Zambia perceive their risk of HIV exposure, aiming to understand factors influencing this self-appraisal and identify opportunities for engaging them in preventive measures like PrEP.
  • Using cross-sectional data from 2016/2017, the researchers analyzed sexual-related factors associated with perceived HIV risk and assessed PrEP eligibility based on national guidelines.
  • Results show a discrepancy between reported perceived risk and actual HIV risk factors, with some associations found, particularly relating to partners' HIV exposure and other sexual behaviors, highlighting a need for targeted interventions in this demographic.
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Article Synopsis
  • - The study assessed treatment outcomes for tuberculosis in children aged 0-14 in Lusaka, Zambia from 2015 to 2019, focusing on the challenges faced in diagnosing and treating childhood tuberculosis.
  • - Out of 2,531 children treated, only 1,495 had their outcomes evaluated; 94.1% achieved successful outcomes, but 5.1% faced unsuccessful treatment outcomes, including death and loss to follow-up.
  • - Extrapulmonary tuberculosis was identified as a significant risk factor for unsuccessful treatment, indicating that this population needs targeted interventions to improve outcomes, aligning with WHO treatment success goals.
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Article Synopsis
  • - Human African trypanosomiasis is a severe neglected tropical disease that can be fatal without treatment, and the WHO has updated its treatment guidelines after a thorough review.
  • - Fexinidazole is now the preferred first-line treatment for patients aged 6 years and over who weigh at least 20 kg, eliminating the need for invasive lumbar punctures for staging the disease.
  • - While fexinidazole improves treatment options and reduces the risk of severe side effects from previous medicines, it remains unavailable for children who don't meet the age or weight criteria, making interim use of pentamidine necessary in some cases.
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Article Synopsis
  • The study aimed to evaluate healthcare providers' knowledge of cardiovascular disease risks associated with preeclampsia across five facilities in Lusaka, Zambia, between August and October 2023.
  • It utilized a self-administered questionnaire for various healthcare professionals and found the average knowledge score to be 4.7 out of 7, indicating good awareness, particularly regarding hypertension and heart disease.
  • The results suggested a disparity in knowledge based on professional role and experience, with nurses generally less informed than doctors, highlighting a need for targeted interventions to improve understanding and practice in this area.
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Interpreting was not something I had aspired to do; however, when I realised that there was a genuine scarcity for people in need of such services, I made a conscious decision to work as a freelance interpreter. The translation and interpreting service operates through various methods, such as face-to-face, video interpreting or remote interpreting by phone, depending on the need and the availability of both the user and the service provider. Usually, the doctors and other healthcare staff who work in the National Health Service book the interpreters through various interpreting companies, if patients are unable to speak the English language to express themselves.

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Background: Surgical site infections (SSIs) are on the rise and are a global concern as they complicate the recovery of patients postoperatively. Bacterial colonization of the patient's skin and alimentary tract are known to be major contributing sources to SSIs. However, Zambia lacks data relating to carriage rates of antibiotic-resistant rectal among surgical patients.

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A cross-sectional study of associations between the C-sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy.

Am J Clin Nutr

December 2024

Rutgers Global Health Institute, Department of Biostatistics and Epidemiology, School of Public Health, Rutgers, the State University of New Jersey, New Brunswick, NJ, United States. Electronic address:

Article Synopsis
  • Environmental enteropathy (EE) is a condition affecting children in low-resource settings due to exposure to enteric pathogens, and a new noninvasive breath test (C-SBT) to assess carbohydrate digestion was developed and validated.
  • The study aimed to link the C-SBT results to the lactulose/rhamnose ratio (LR) and identify their relationship with child growth, as well as investigate connections with socio-economic factors, dietary diversity, and other EE biomarkers.
  • Results indicated variability in C-SBT and LR measurements across different sites, with some associations found between child growth and test timing, but no significant links between C-SBT and LR or overall growth metrics were established.
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Introduction: Harmful alcohol use is associated with significant risks to public health outcomes worldwide. Although data on harmful alcohol use have been collected by population-based HIV Impact Assessment (PHIA), there is a dearth of analysis on the effect of HIV/ART status on harmful alcohol use in the Sub-Saharan Africa (SSA) countries with PHIA surveys.

Methods: A secondary analysis of the PHIA surveys: Namibia (n = 27,382), Tanzania (n = 1807), Zambia (n = 2268), Zimbabwe (n = 3418), Malawi (n = 2098), Namibia (n = 27,382), and Eswatini (n = 2762).

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Article Synopsis
  • Assessing the digestive capabilities of the gastrointestinal tract in children, especially non-invasively, is challenging due to complex processes and variability in how functions are measured.
  • * Childhood environmental enteropathy (EE) plays a key role in issues like growth and nutrition, linking poor nutrient absorption to conditions like malnutrition and cognitive impairment.
  • * The review highlights mechanisms behind malabsorption in children, identifies promising non-invasive breath tests to evaluate this issue, and emphasizes the need for future research on its impact on growth and cognitive function.
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During the COVID-19 pandemic, the need for making testing readily available was recognized as an important factor for individuals to help make informed decisions, including to isolate or seek care, and for policymakers to control transmission. Toward this end, FIND and the Access to COVID-19 Tools Accelerator funded 16 rapid operational research studies and one implementation project in Africa, the Caribbean, and Asia evaluating the utility, acceptability, and feasibility of different community-based SARS-CoV-2 testing approaches. Here, we discuss common factors and challenges encountered during study implementation.

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