Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine.

Objectives: We measured and compared serum asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine levels in patients undergoing coronary artery revascularization.

Methods: Two groups of patients with coronary artery disease were subjected to coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass (CPB; n = 20) or with off-pump CABG surgery (OPCABG; n = 21). Blood samples for measurements of ADMA, SDMA, and L-arginine were withdrawn and determined by liquid chromatography-tandem mass spectrometry from the coronary sinus (CS) and from the peripheral vein.

Immunohistochemistry on epoxy resin-embedded bone marrow biopsy experience with 936 cases.

The investigators adapted a method to process 150 bone marrow trephine biopsies per year at a general hospital providing pathological diagnosis for a subcenter hematological ward. In brief, specimens were fixed in 10% formaldehyde and embedded in epoxy resin at 56°C without decalcification. The resin was extracted with sodium-etoxide from the sections.

[Mortality rate of acute heart attack in Zalaegerszeg micro-region. Results of the first Hungarian 24-hour acute ST-elevation myocardial infarction intervention care unit].

Unlabelled: Morbidity and mortality rates of acute heart attack emphasize the significance of this patient group worldwide. The prompt and exact diagnosis and the timing of adequate therapy is crucial for this patients. Modern supply of acute heart attack includes invasive cardiology intervention, primer percutaneous coronary intervention.

Experience with Endeavor stent implantations.

Unlabelled: Restenosis is the most common disadvantage of percutaneous coronary interventions. The incidence of restenosis can be lowered with the use of stents. After the use of stents, 'in-stent' restenosis can occur.

[Experience with CT colonography (virtual colonoscopy) from the view of gastroenterologists].

Unlabelled: Colonoscopy is a golden standard in the diagnostics of intraluminal diseases of the large intestine. Its advantage is the possibility of histological sampling (biopsy) and therapeutical interventions. In case of technical difficulties (stenosis, severe inflammation, diverticulosis, anatomical alterations) or lack of informed consent of the patient double contrast colonography is the routine diagnostic tool for the examination of the entire large intestine.

Influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations.

Introduction: Experimental studies have demonstrated that dextran-70 reduces the leukocyte-endothelium interaction, but clinical evidence is still lacking. Our objective was to justify the anti-inflammatory effect of dextran-70 following cardiac operations.

Methods: Forty patients undergoing coronary bypass surgery (n = 32) or aortic valve replacement (n = 8) were enrolled in this prospective, randomized, double-blind study.

Idiopathic myelofibrosis with prominent postsplenectomy erythroblastosis terminating in acute myeloid transformation.

Idiopathic myelofibrosis is a myeloproliferative disease with poor prognosis and without sufficient therapy. Acute leukemic transformation occurs in 15% of patients. The authors report the case of a 63 year old myelofibrotic patient treated with splenectomy.

[Ultrasound screening program for neonates and infants in Hungary].

Introduction: A children's hospital in Budapest (The Madarász Street Children's Hospital) and two children's department of two county hospitals (Toldy Ferenc Hospital, Cegléd and Zala County Hospital, Zalaegerszeg) started a common ultrasound screening programme for children in 1990.

Objectives: This three screening centres agreed which illnesses, pathological states and developmental disorders will be screened. In neonatological departments this screening was carried out usually in the first week of life.

Biclonal primary plasma cell leukemia.

Authors present a multiparameter pathological study in a case of rapid biclonal primary plasma cell leukemia. The immunohistochemical data revealed aberrant phenotypes (monocyte, epithelial and T-cell) probably in connection with microenvironmental influences. Biclonality can be attributed to class switching during malignant transformation.

Use of Brulamycin (tobramycin) eye drops in the preoperative and postoperative treatment of ophthalmotomies.

The conjunctival bacterium flora was examined during the preoperative and postoperative treatment of 200 patients who underwent intraocular surgery. Brulamycin eye drops (15 mg tobramycinum in 5 ml solution) were given to 100 patients and Oculogutta neomycin (50 mg neomycinum sulfuricum in 100 ml solution) to 100 patients. The effectivity, objective and subjective side-effects of the two drugs, and resistance to the drugs were examined.

Treatment of polyglandular autoimmune syndrome with cyclosporin-A.

The case history of a 30-year-old female patient is reported. Following an unknown viral infection that had occurred four years earlier, insulin-dependent diabetes mellitus vitiligo, Addison's disease, amenorrhoea, hyperthyreosis and, finally, severe pancytopenia with dominant thrombocytopenia developed. On the basis of clinical aspects and laboratory findings, an infrequent polyglandular autoimmune syndrome (type II) was verified.

Effect of Paxirasol aerosol on the clinical condition and objective functional respiratory parameters of obstructive respiratory tract disease patients.

Paxirasol aerosol applied in daily 3 x 5-puff doses was well tolerated by the examined patients. In the course of the 21-day therapy the laboratory findings did not change-haemopoetic or liver injury was not observed. On two-thirds of the patients the amount of sputum decreased in response to Paxirasol aerosol but the symptoms accompanying expectoration did not change notably.