Investigation of adsorption/desorption properties of vancomycin on ionic liquid modified magnetic activated carbon in aqueous solutions and cytotoxicity evaluation of synthesized nanoparticles.

Effluents containing antibiotics raise concerns due to their potential to promote or sustain bacterial resistance and disrupt essential cycles and processes critical to aquatic ecology, agriculture, and animal farming. Vancomycin is a glycopeptide antibiotic, recognized as the treatment for cases in which other antibiotics are unsuccessful. The efficient elimination of antibiotics plays a crucial role in managing antibiotic pollution.

Ataxia With Vitamin E Deficiency: Case Series, Vitamin E Therapy Response, Founder Effect, and In Silico Analysis.

Ataxia with Vitamin E Deficiency (AVED) is a rare autosomal recessive genetic disorder, that caused by pathogenic variants in the TTPA gene, which encodes the alpha-tocopherol transfer protein. This study investigates eight patients from three consanguineous Iranian families, using exome sequencing (ES) and Sanger sequencing to identify novel pathogenic variants in the TTPA gene. Two variants were identified: c.

Diagnostic Value of Hepatic Mast Cell Concentration (MCC) in NAFLD and NASH Severity and Fibrosis Grade.

Background & Objective: Mast cells play a role in the immune responses to fatty liver disease. The present study aimed to investigate the diagnostic value of hepatic mast cell concentration (MCC) in NAFLD and NASH severity and fibrosis grade.

Methods: The present cross-sectional unremarkable hepatic histology, NAFLD, or NASH cases were enrolled.

Effect of selective and family-based prevention on addiction susceptibility, affiliation with deviant peers, risk-taking, and risk and protective factors of substance use in high-risk adolescents: A randomized clinical trial.

Background: Adolescents with a background in families affected by substance use exhibit an increased susceptibility to developing individual substance-related or other mental disorders. Consequently, they represent a crucial demographic for targeted preventive interventions. The current study examined the impact of selective prevention (SP) and family-based prevention (F-BP) measures on addiction susceptibility, affiliation with deviant peers (ADP), risk-taking, and risk and protective factors (RPFs) related to substance use among high-risk adolescents.

The relationship between breast cancer and thyroid autoimmune disorders in southeast Iran: A case-control study.

To better understand the role of thyroid hormones in regulating the growth of breast epithelial cells and the estrogen-like effects of these hormones, the present study was conducted to investigate the relationship between breast cancer and thyroid autoimmune disorders in southeast Iran women. In this case-control study, in the case group, all newly diagnosed breast cancer pa-tients referred to the oncology clinics in Zahedan city in years 2021‒2022 were studied. The num-ber of participants in each group was represented by 40 breast cancer patients.

Release of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) from cigarette butts into the aquatic environment: Levels and ecotoxicity.

Discarded cigarette waste may leach toxic elements and can contaminate different environments. In this study, the levels of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in cigarette butts (CBs) leachates were determined, and the release rate of these pollutants from three CBs types such as smoked CBs with and without tobacco (SCBs and SFs) and unsmoked filters (USFs) were examined. The mean concentration levels of PCBs compounds were View Article and Find Full Text PDF

Association between , , , and gene polymorphisms and breast cancer risk.

Aim: In this study, we examined the polymorphisms of (rs13252298, rs1456315), (rs4848320) (rs7158663), (rs7853346) genes in BC patients and compared it with healthy individuals in an Iranian population.

Method: The assessment of genetic polymorphisms was conducted using PCR - RFLP and PCR-Tetra ARMS methods.

Results & Conclusion: The results showed that Codominant, Dominant and G allele of rs13252298 polymorphism and Dominant of rs1456315 polymorphism are correlated with increased risk of BC.

Repurposing raltegravir for reducing inflammation and treating cancer: a bioinformatics analysis.

Inflammation is a defensive mechanism that safeguards the human body against detrimental stimuli. Within this intricate process, ADAM17, a zinc-dependent metalloprotease, emerges as an indispensable element, fostering the activation of diverse inflammatory and growth factors within the organism. Nonetheless, ADAM17 malfunctions can augment the rate of growth, inflammatory factors, and subsequent damage.

The Effect of Job Skills and Job Burnout on Job Satisfaction Among Health Information Management Staff.

Background And Aims: The health information management department faces multiple challenges such as multiple tasks, high workload, role ambiguity and conflict, and work pressure. In addition, informatics and health information technology tools are continuously used in this sector. Based on studies, the use of information technology affects job burnout and job satisfaction.

Assessment of immunogenicity and protective efficiency of multi-epitope antigen-loaded in mannan decorated PLGA nanoparticles against tuberculosis.

The antigen-targeting to dendritic cells (DCs) has gained increasing attention as the potential approach for immunotherapy in recent years due to the ability of DCs to regulate innate and adaptive immunity. In the present study, the immunogenicity and protective efficiency of mannan-decorated PLGA nanoparticles (NPs) loaded with multi-epitopes mycobacterium tuberculosis antigen (HspX-Ppe44-EsxV) were evaluated as a targeted delivery system to DCs. For this purpose, PLGA nanoparticle formulations were prepared and subsequently decorated by mannan.

Randomized controlled trial evaluating the efficacy of the "water on tray" anesthesia technique compared to the Halsted technique.

Objective: With respect to the high failure rate of conventional IANB technique and other associated disadvantages, in this study we focused on an alternative called Water on Tray technique and assessed the efficiency of this method compared to the conventional technique.

Materials And Methods: This single-blind, single center randomized controlled trial was carried out among 90 individuals referred to the dental clinic of the International Branch of Guilan University of Medical Sciences (IB-GUMS) from November to December of 2017. The patients were randomly assigned into two groups.

Combining the induced pluripotent stem cell (iPSC) technology with chimeric antigen receptor (CAR)-based immunotherapy: recent advances, challenges, and future prospects.

After experiencing many ups and downs, chimeric antigen receptor (CAR)-T cell therapy has reached a milestone as an anti-cancer method, as evidenced by the increasing number of clinical trials and approved products. Nonetheless, there is a real need to optimize CAR-T cell therapy and overcome its existing limitations. The importance of cellular starting material for generating CAR-T cells is undeniable, as the current personalized manufacturing approach is the main roadblock to providing a fast, affordable, and standard treatment for patients.

Predictive model for converting optic neuritis to multiple sclerosis; decision tree in focus.

Background: Optic neuritis (ON) can be an initial clinical presentation of multiple sclerosis This study aims to provide a practical predictive model for identifying at-risk ON patients in developing MS.

Method: We utilized data from the Optic Neuritis Treatment Trial study, which enrolled 457 patients aged from 18 to 46 years, all diagnosed with acute ON. These patients underwent up to 15 years of neurological and ophthalmologic examinations and imaging.

LncRNA MEG3, GAS5, and HOTTIP Polymorphisms Association with Risk of Polycystic Ovary Syndrome: A Case-Control Study and Computational Analyses.

As a multifactorial and endocrine disease, polycystic ovary syndrome (PCOS) affects approximately 5-20% of women worldwide. Recently, long noncoding RNAs (lncRNAs) have emerged as potent predictors of a particular phenotype in PCOS. Our preliminary study examines the link between polymorphisms in lncRNAs MEG3, HOTTIP, and GAS5 and the risk of PCOS.

Correction: Association between type 2 diabetes and branched chain amino acids (BCAA); a case-control study.

[This corrects the article DOI: 10.1007/s40200-023-01247-9.].

The Immunomodulatory Effects of Curcumin on Forkhead Box O1 and MicroRNA-873 in Patients with Osteoarthritis.

Osteoarthritis (OA) is among the most prevalent articular disorders, whose incidence is directly related to aging. Due to the antiinflammatory potential of curcumin as the active component of turmeric, the present study evaluated the effects of curcumin on the expression of genes related to T helper 17 (Th17), including forkhead box p3 (FOXP3), forkhead box o1 (FOXO1), transforming growth factor-β (TGFB1) and microRNA-873, human (HSA-MIR-873), in OA patients. Female patients with knee OA (n=30) were randomly categorized into 2 groups, including the intervention group who received curcumin (n=15) and the placebo (n=15) in a double-blind clinical trial for 3 months.

Application of cloud point extraction coupled with derivative spectrophotometry to remove binary mixture of Cresol Red and Methyl Orange dyes from aqueous solutions: Box-behnken design optimization.

Cloud point extraction (CPE) was employed to eliminate Cresol Red (CR) and Methyl Orange (MO), as anionic dyes in a binary mixture from aqueous solutions. To remove these dyes Triton X-100 and NaCl at pH 5.7 were utilized.

Mitochondrial Pathogenic Mutations and Expression Pattern of Oxidative Phosphorylation Genes in COVID-19 Patients.

Mitochondrial missense mutations and pathogenic variants have been implicated in the pathogenesis of COVID-19. This study evaluated the role of mitochondrial DNA (mtDNA) mutations and changes in gene expression in the progression of COVID-19 and their correlation with clinical characteristics. Next-generation sequencing with high throughput was used to identify mtDNA mutations in 30 COVID-19 patients compared to 20 healthy controls.