Huge bilharzial polyp mimicking colon cancer.

Bilharziasis (Schistosomiasis) is the third devastating tropical disease globally and is endemic in many countries including Egypt. The pathology of chronic colonic schistosomiasis results from egg-induced immune response, granuloma formation, and associated fibrotic changes that may manifest as bloody diarrhea, cramping, and, eventually, inflammatory colonic polyposis. Huge polyps complicating schistosomiasis are not frequently reported in the literature.

International microsurgery simulation society (IMSS) consensus statement on the minimum standards for a basic microsurgery course, requirements for a microsurgical anastomosis global rating scale and minimum thresholds for training.

Introduction: Microsurgery is a surgical technique that uses optical magnification as well as specific instruments to address necessary reconstructive procedures in different medical specialties. The apprenticeship of this technique requires overcoming a steep learning curve. There is a need for standardization of the training criteria in microsurgery.

Survival and reduction in foodborne bacteria using methyl cellulose film doped with europium oxide nanoparticles.

The study validated the efficacy of methyl cellulose films doped with different concentration of EuO nanoparticles to inactivate foodborne pathogens. EuO nanoparticles were added to the methyl cellulose solution with different weight percentages (0.0, 0.

Patched homolog 1 (PTCHI) gene mutations can predict the outcome of chronic myeloid leukemia patients?

Background: The Hedgehog (Hh) pathway is stimulated by inactivating mutations of Patched Homolog 1 . There is accumulating evidence that Hh signaling plays a critical role in the pathogenesis of various haemopoietic malignancies. Particular interest has focused on the role of Hh signaling in chronic myeloid leukemia (CML).

Synthesis, computational studies, antimycobacterial and antibacterial properties of pyrazinoic acid-isoniazid hybrid conjugates.

Benzotriazole and microwave mediated syntheses led to a new set of hybrid conjugates of pyrazinoic acid with isoniazid amino acid linkers in excellent yields with retention of chirality. Microbiological screening of the synthesized conjugates revealed an exceptionally high activity against some of the pathogenic bacterial strains at low concentrations. Promising antimycobacterial properties were observed against tuberculous and non-tuberculous mycobacteria.

Glyceryl trinitrate blocks staphyloxanthin and biofilm formation in .

Background: is an important nosocomial bacterium that is responsible for a number of infections that may be fatal. The treatment of such infections is limited by emergence of antibiotic resistance. Targeting virulence of may provide an alternative option to antibiotic that may bypass the emergence of resistant strains due to lack of stress on viability.

The Diagnostic Value of Arginase-1, FTCD, and MOC-31 Expression in Early Detection of Hepatocellular Carcinoma (HCC) and in Differentiation Between HCC and Metastatic Adenocarcinoma to the Liver.

Background: Early detection of small HCC and differentiation between HCC from AC metastatic to the liver is very essential for surgical pathologists, due to different treatment modalities. Immunohistochemistry plays a very important role in such conditions. In our study, we aimed to identify the diagnostic benefits of Arginase-1, FTCD& MOC-31 in the early detection of HCC in normal or cirrhotic liver, differentiation between HCC and metastatic ACs to the liver, and for early detection of small micro-metastases from ACs to liver.

Relationship between Sap prevalence and biofilm formation among resistant clinical isolates of .

Background: Fungal infections represent a serious health problem especially in immunocompromised individuals. is the most common fungi that cause superficial and systemic infections with high mortality rates. Anti-fungal resistance of may be attributed to its virulence.

Brain magnetic resonance spectroscopy (MRS) as a diagnostic tool for detecting early neurological changes in children with Wilson's disease.

Purpose: Although brain magnetic resonance spectroscopy (MRS) imaging findings in adult Wilson disease (WD) have been explained in extensive details, a paucity of information currently exists regarding brain MRS imaging findings in pediatric WD. The purpose of this study was to clarify the role of brain MRS in detecting early metabolite abnormalities in children with WD.

Patient And Methods: A case-controlled prospective study included 26 children with WD and 26 healthy controls.

Silencing the nosocomial pathogen by glyceryl trinitrate.

Background: Quorum sensing is a cell-to-cell communication system in bacteria that controls the production of virulence factors. is a causative agent of hospital-acquired infections that shows high resistance to antibiotics. This makes the treatment of these infections difficult.

Dynamic integration and excision of filamentous phage XacF1 in pv. , the causative agent of citrus canker disease.

Inovirus XacF1 (7325 nucleotides) is integrated into the genome of pv. () strains at the host site (B) by the host XerC/D recombination system. The XacF1 P sequence is located within the coding region of ORF12, a possible phage regulator.

Repurposing metformin as a quorum sensing inhibitor in .

Background: Quorum sensing is a mechanism of intercellular communication that controls the production of virulence factors in . Inhibition of quorum sensing can disarm the virulence factors without exerting stress on bacterial growth that leads to emergence of antibiotic resistance.

Objectives: Finding a new quorum sensing inhibitor and determining its inhibitory activities against virulence factors of PAO1 strain.

Serum miRNA-499 and miRNA-210: A potential role in early diagnosis of acute coronary syndrome.

In clinical practice, there is still a need for novel biomarkers, which can reliably rule in or rule out acute coronary syndrome (ACS) immediately on admission. This is of particular interest in patients with unstable angina (UA) and non-ST-segment elevation myocardial infarction (NSTEMI) in whom diagnostic uncertainty is high. The aim of the present study is to evaluate the potential role of miRNA-499 and miRNA-210 as novel molecular biomarkers for early diagnosis of UA and NSTEMI suspected patients presented at the emergency unit.

The filamentous phage XacF1 causes loss of virulence in Xanthomonas axonopodis pv. citri, the causative agent of citrus canker disease.

In this study, filamentous phage XacF1, which can infect Xanthomonas axonopodis pv. citri (Xac) strains, was isolated and characterized. Electron microscopy showed that XacF1 is a member of the family Inoviridae and is about 600 nm long.

Tailoring of chronic lymphatic leukemia therapy.

Chronic lymphocytic leukemia (CLL) remains an incurable disease, with all patients who require therapy destined to relapse and understanding of the pathophysiology of chronic lymphocytic leukemia has advanced significantly. It is now clear that chronic lymphocytic leukemia is a relatively proliferative disorder that requires the help of its microenvironment to be maintained and to progress. The stimulation of the chronic lymphatic leukemia cell occurs in most, if not all, patients through antigen stimulation via the B cell receptors.

Interactions between Co-Habitating fungi Elicit Synthesis of Taxol from an Endophytic Fungus in Host Taxus Plants.

Within a plant, there can exist an ecosystem of pathogens and endophytes, the latter described as bacterial and fungal inhabitants that thrive without causing disease to the host. Interactions between microbial inhabitants represent a novel area of study for natural products research. Here we analyzed the interactions between the fungal endophytes of Taxus (yew) trees.

Phytoremediation of water and soil contaminated with imidacloprid pesticide by Plantago major, L.

Broadleaf plantain plant (Plantago major L.) was used in phytoremediation of imidacloprid insecticide in water and soils. For the Freundlich model the constant related to the biosorption capacity (Kf) of imidaclaprid were respectively, 7.