Prediction of the Lethal Outcome of Acute Recurrent Cerebral Ischemic Hemispheric Stroke.

Stroke-induced mortality is the third most common cause of death in developed countries. Intense interest has focused on the recurrent ischemic stroke, which rate makes up 30% during first 5 years after first-ever stroke. This work aims to develop criteria for the prediction of acute recurrent cerebral ischemic hemispheric stroke (RCIHS) outcome on the basis of comprehensive baseline clinical, laboratory, and neuroimaging examinations.

Prolactin in hypertensive men with androgen deficiency: an éminence grise?

Objective: Introduction: Considering significant gap of convincing knowledge in the field of cardiovascular effects of prolactin and its role as a stress hormone in men precise investigations of these peculiarities has become necessary. The aim of this study was to find out the relationship of prolactin concentration with parameters of arterial stiffness in hypertensive men with low testosterone.

Patients And Methods: Materials and methods: In total 83 men were examined including 27 apparently healthy individuals as the control group.

DYNAMICS OF THE VEGETATIVE NERVOUS SYSTEM FUNCTIONAL STATE IN INTERACTION WITH THE CHANGES IN ADRENOCORTICOTROPIC AND SOMATOTROPIC HORMONES IN PATIENTS WITH SEROUS MENINGITIS.

The study included 64 patients with serous meningitis, in which the heart rate variability (HRV) spectrum, the content of ACTH and STH in serum was studied in the course of the commonly accepted treatment. The purpose of the study was to analyze the dynamics of indicators of functional state of the autonomic nervous system in correlation with changes of adrenocorticotropic and somatotropic hormones in patients with serous meningitis. According to the results, serous meningitis were predominantly moderate in severity, with generalization in the clinical picture dominated through general toxicosis, general cerebral and meningeal syndromes, but changes in the spectral parameters of HRV showed a marked imbalance with a shift in the functional activity of the autonomic nervous system towards vagotonia in combination with an ACTH level increase and STH decrease in serum (p<0.

Morphological and physiological, biological and epidemiological features of acariana of the genus ixodes (latreille, 1795) - human ectoparasites in biogeocenoses of ternopil region.

Objective: Introduction: Ixodine are an integral part of many biotopes, in particular rarefied deciduous and mixed forests, gardens, parks, squares, semi-steppe and steppe areas, etc. Over the past decade, the role of ticks has increased in the transfer of pathogens of many diseases of animals and humans. In particular, these are tick borelliosis, anaplasmosis, erlichiosis, babesiosis, and etc.

Astroglia in Sepsis Associated Encephalopathy.

Cellular pathophysiology of sepsis associated encephalopathy (SAE) remains poorly characterised. Brain pathology in SAE, which is manifested by impaired perception, consciousness and cognition, results from multifactorial events, including high levels of systemic cytokines, microbial components and endotoxins, which all damage the brain barriers, instigate neuroinflammation and cause homeostatic failure. Astrocytes, being the principal homeostatic cells of the central nervous system contribute to the brain defence against infection.

Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications.

Background: The aim of this post hoc analysis of a large cohort study was to evaluate the association between night-time surgery and the occurrence of intraoperative adverse events (AEs) and postoperative pulmonary complications (PPCs).

Methods: LAS VEGAS (Local Assessment of Ventilatory Management During General Anesthesia for Surgery) was a prospective international 1-week study that enrolled adult patients undergoing surgical procedures with general anaesthesia and mechanical ventilation in 146 hospitals across 29 countries. Surgeries were defined as occurring during 'daytime' when induction of anaesthesia was between 8:00 AM and 7:59 PM, and as 'night-time' when induction was between 8:00 PM and 7:59 AM.

Directed Search of Anti-inflammatory Agents Among (3HQuinazoline- 4-ylidene)hydrazides of N-protected Amino acids and their Heterocyclization Products.

Background: (Quinazoline-4-ylidene)hydrazides are valued intermediates in modern organic chemistry, as they are commonly used for the synthesis of substituted [1,2,4]triazolo[1,5-c]quinazolines.

Objective: Unknown N-acyl-2-([1,2,4]triazolo[1,5-c]quinazoline-2-yl)-alkyl-(alkaryl-, aryl-) amines were synthesized and evaluated for anti-inflammatory potential.

Methods: The peculiarities of the synthesized compounds structures were studied by IR-, NMR spectroscopy and chromatography-mass spectrometry and were discussed in detail.

Comparison of biosimilar CT-P10 and innovator rituximab in patients with rheumatoid arthritis: a randomized controlled Phase 3 trial.

This multinational, randomized, double-blind trial, (ClinicalTrials.gov identifier NCT02149121) was designed to demonstrate equivalence in pharmacokinetics and efficacy between CT-P10 and innovator rituximab (RTX) in patients with rheumatoid arthritis (RA). Adults with active RA were treated with CT-P10, United States-sourced RTX (US-RTX; Rituxan®), or European Union-sourced RTX (EU-RTX; MabThera®) at weeks 0 and 2.

NEPHROPATHY IN EARLY RHEUMATOID ARTHRITIS PATIENTS: DOES A SIGNIFICANT RISK EXIST?

Objective of the study layed in assessment of the pathophysiological relation between cell-mediated immunity (tumor necrosis factor-alpha (TNF-α) inflammatory cytokine) activation and renal dysfunction in the patients with early rheumatoid arthritis. We analyzed the data from 35 early rheumatoid arthritis (RA) patients of average age of 50,71±2,25 years (ranged 18-76 years, 80% of women) with 9,21±0,43 months mean duration of the disease by the time of the study initiation. Urine and blood tests were performed to verify the main indicators of kidney function and inflammation cytokines significant interaction.

An Overview of Currently Available Antimalarials.

Background: Despite the substantial progress over the time, malaria remains a major public health concern and causing hundreds of thousands of deaths. Resistance to the available antimalarial therapy increases threat to the global public health.

Objective: Overview of currently available antimalarials.

Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs.

The known methods for synthesis of thioxopyrimidines and their condensed analogs with exocyclic sulfur atom are summarized and discussed. The most popular approaches are based on [3+3], [4+2], [5+1] cyclization processes or domino reactions. The literature data analysis shows that the title compounds possess diverse biological activities, such as antioxidant, radioprotective, analgesic, antiinflammatory, antihypertensive, anxiolytic, anamnestic, anticonvulsant, antimicrobial, fungicidal, herbicidal, antiviral, and anticancer.

Synthesis and Antimicrobial Activity of 6-Thioxo-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]-quinazolin-2-one Derivatives.

Potassium 8-R(1)-9-R(2)-10-R(3)-3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-thiolates 2.1-2.26 were synthesized via cyclocondensation of 6-R-3-(3-R(1)-4-R(2)-5-R(3)-aminophenyl)-1,2,4-triazin-5-ones 1.