Efficacy and safety of GLP-1 receptor agonists combined with SGLT-2 inhibitors in elderly patients with type 2 diabetes: a meta-analysis.

Objective: To evaluate the efficacy and safety of combining GLP-1 receptor agonists (GLP-1RA) with SGLT-2 inhibitors (SGLT-2i) in elderly patients with type 2 diabetes mellitus (T2DM).

Methods: A comprehensive search of Web of Science, Cochrane Library, Embase, and PubMed was conducted from inception to May 2024. Eligible randomized controlled trials (RCTs) assessing the efficacy of GLP-1RA combined with SGLT-2i for managing T2DM in elderly patients were included.

The abnormal expression of CCR4 and CCR6 on Tregs in rheumatoid arthritis.

The study aims to investigate the frequency of CD4(+)CD25(+)Foxp3(+)CD127(-) T regulatory cells (Tregs) and the expression of CCR4, CCR6 and/or other chemokine receptors on Tregs in peripheral blood (PB) in patients with rheumatoid arthritis, as well as in PB, draining lymph nodes (dLNs), lungs and spleens in collagen-induced arthritis (CIA) mice. We also study the possible role of CCR4 and CCR6 abnormal expression on Tregs in RA patients and the underlying mechanisms. The numbers of Tregs and chemokine receptors expression profile on Tregs in PB from RA patients and healthy controls were investigated by flow cytometry (FACS) using three- or four-color intracellular staining.