Ni Single Atoms/FeN Nanoparticles Supported by N-Doped Carbon Hollow Nanododecahedras with Nanotubes on the Surface for Efficient Electro-Reduction of CO to CO.

The transition metal single atoms (SAs)-based catalysts with M-N coordination environment have shown excellent performance in electrocatalytic reduction of CO, and they have received extensive attention in recent years. However, the presence of SAs makes it very difficult to efficiently improve the coordination environment. In this paper, a method of direct high-temperature pyrolysis carbonization of ZIF-8 adsorbed with Ni and Fe ions is reported for the synthesis of Ni SAs and FeN nanoparticles (NPs) supported by the N-doped carbon (NC) hollow nanododecahedras (HNDs) with nanotubes (NTs) on the surface (Ni SAs/FeN NPs@NC-HNDs-NTs).

Robert's uterus treated with ultrasound-guided laparoscopy and hysteroscopy: a case report.

We report the case of a woman in her early 30 s who was diagnosed with Robert's uterus. She had been experiencing progressive dysmenorrhea for a decade and sought treatment for infertility at our hospital. Preoperative ultrasound imaging resulted in a misdiagnosis of a complete uterine septum with an accompanying ovarian cyst.

Rat models of postintracerebral hemorrhage pneumonia induced by nasal inoculation with or intratracheal inoculation with LPS.

Background: A stable and reproducible experimental bacterial pneumonia model postintracerebral hemorrhage (ICH) is necessary to help investigating the pathogenesis and novel treatments of Stroke-associated pneumonia (SAP).

Aim: To establish a Gram-negative bacterial pneumonia-complicating ICH rat model and an acute lung injury (ALI)-complicating ICH rat model.

Methods: We established two standardized models of post-ICH pneumonia by nasal inoculation with () or intratracheal inoculation with lipopolysaccharide (LPS).

Recent advances in designable nanomaterial-based electrochemical sensors for environmental heavy-metal detection.

The detection of heavy metals serves as a defence measure to safeguard the well-being of the human body and the ecological environment. Electrochemical sensors (ECS) offer significant benefits such as exceptional sensitivity, excellent selectivity, affordability, and portability. This review begins by elucidating the ECS principles and delves into recent advancements in the field of heavy metal detection, including the use of metal nanoparticles, carbon-based nanomaterials, and organic framework materials.

Anthropometric and metabolic parameters associated with visceral fat in non-obese type 2 diabetes individuals.

Background And Aim: Visceral fat (VF) was proved to be a more precise predictor of atherosclerotic cardiovascular disease (ASCVD) risk in individuals with type 2 diabetes mellitus (T2DM) than body mass index (BMI) itself. Even when the BMI was normal, visceral fat area (VFA) ≥ 90 cm² could raise the ten-year risk of developing ASCVD. Therefore, it was worth evaluating the association of influencing factors with high VF in non-obese T2DM individuals.

Non-pharmacological interventions for primary hypertension: a systematic review and network meta-analysis protocol.

Introduction: Primary hypertension (PH) affects over one billion individuals globally, yet less than 30% achieve controlled blood pressure (BP) with medication. Many patients require a combination of multiple medications to reach targets, but adverse effects and financial burdens undermine adherence. Additionally, prehypertension affects 25%-50% of adults, increasing the risk of cardiovascular complications.

Sustainable, biodegradable, and recyclable bioplastics derived from renewable carboxymethyl cellulose and waste walnut shell.

Manufacturing water-stable carboxymethyl cellulose (CMC) films as an alternative to commercial plastics is a promising solution to address plastic pollution. In this study, waste walnut shell (WS) was used as a natural lignocellulosic filler, glycerol as a plasticizer, and citric acid (CA) as a crosslinking agent for preparing high-performance CMC-based bioplastics through a one-pot casting method. When WS content was 12 wt%, the obtained CWGA-12 after optimization exhibited excellent mechanical properties (tensile strength ≈18.

Syringin inhibits the crosstalk between macrophages and fibroblast-like synoviocytes to treat rheumatoid arthritis via PDE4.

Background: Syringin (SRG) is well-known for its anti-inflammatory effects. However, its pharmacological mechanisms against rheumatoid arthritis (RA) are not fully understood.

Materials And Methods: We assessed the anti-RA effects of SRG using a collagen-induced arthritis (CIA) rat model.

BTSegDiff: Brain tumor segmentation based on multimodal MRI Dynamically guided diffusion probability model.

In the treatment of brain tumors, accurate diagnosis and treatment heavily rely on reliable brain tumor segmentation, where multimodal Magnetic Resonance Imaging (MRI) plays a pivotal role by providing valuable complementary information. This integration significantly enhances the performance of brain tumor segmentation. However, due to the uneven grayscale distribution, irregular shapes, and significant size variations in brain tumor images, this task remains highly challenging.

Polyprenylated Xanthones Isolated from Resins and Their Beneficial Effects on Rice Blast Disease.

Five undescribed polyprenylated xanthones (, , , , and ) and 27 known compounds were isolated from resins, and the antifungal activities of 15 of them were investigated. Compound exhibited notable in vitro antifungal effects against with an IC value of 3.54 μg/mL, superior to isoprothiolane (10.

The safety, tolerability, pharmacokinetics and pharmacodynamics of an optimized dual GLP-1/GIP receptor agonist (BGM0504) in healthy volunteers: A dose-escalation Phase I study.

Objective: Previous experiments have demonstrated that BGM0504, a GLP-1R/GIPR dual agonist drug by molecular dynamics-guided optimization, had enhanced agonistic activity compared to tirzepatide. This study aims to investigate its safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) in Chinese healthy volunteers.

Methods: A randomized, double-blind, placebo-controlled and dose-escalation Phase I study was conducted as follows: a single dose (2.

Genome mining of albocandins A-E from sp. YINM00030.

The natural products of 2,5-diketopiperazines have attracted considerable attention due to their potent pharmacological activities. Guided by genome mining techniques, five albonoursin analogues, designated as albocandins A-E (1-5), were isolated from sp. YINM00030, an actinomycete sourced from the rhizosphere soil of medicinal plants.

Automatic skeletal maturity grading from pelvis radiographs by deep learning for adolescent idiopathic scoliosis.

Adolescent idiopathic scoliosis (AIS) is a three-dimensional spine deformity governed of the spine. A child's Risser stage of skeletal maturity must be carefully considered for AIS evaluation and treatment. However, there are intra-observer and inter-observer inaccuracies in the Risser stage manual assessment.

Light-Driven Stepwise Reduction of Aliphatic Carboxylic Esters to Aldehydes and Alcohols.

The reduction of carboxylic esters to aldehydes and alcohols is a fundamental functional group transformation in chemistry. However, the inertness of carbonyl group and the instability of ketyl radical anion intermediate impede the reduction of carboxylic esters via photochemical strategy. Herein, we described the reduction of aliphatic carboxylic esters with synergistic dual photocatalysis via phenolate-catalyzed single electron transfer process and thiol-catalyzed hydrogen atom transfer process.

Ultra-sensitive and accurate multi-ion detection in biofluids via organic electrochemical transistors.

As an emerging ionic sensor with low-voltage operation (<1 V), biocompatibility, and stable operation in aqueous environments, organic electrochemical transistors (OECTs) have attracted significant research interest for various biofluid-related ion detection, where minor ion concentration variations can effectively reflect health or pathology states. However, OECT-based ion sensors are currently limited by restricted device transconductance g and stabilites, which severely hinder their applications in actual ion sensing scenarios. Here, ultra-sensitive multi-ion sensors based on high-performance n-type vertical OECTs (accumulation mode, g = 58 mS) for Na, K, and Ca detection in a practical biofluid (effluent from continuous renal replacement therapy), are demonstrated with high accuracy and stability, which are comparable to conventional Roche method.

LMSST-GCN: Longitudinal MRI sub-structural texture guided graph convolution network for improved progression prediction of knee osteoarthritis.

Background And Objectives: Accurate prediction of progression in knee osteoarthritis (KOA) is significant for early personalized intervention. Previous methods commonly focused on quantifying features from a specific sub-structure imaged at baseline and resulted in limited performance. We proposed a longitudinal MRI sub-structural texture-guided graph convolution network (LMSST-GCN) for improved KOA progression prediction.

Coherent Strain-Inhibiting Phase Construction of Lithium-Rich Manganese-Based Oxide Toward High Mechanochemical Stability.

A layered lithium-rich manganese-based oxide cathode, containing 3̅ (LiTMO, TM = Mn, Ni, Co) and 2/ (LiMnO) nanodomains, utilizes both transition metals and oxygen redox to yield substantial energy density. However, the inherent heterogeneous nature and distinct nanodomain redox chemistries of layered lithium-rich oxides will inevitably cause pernicious lattice strain and structural displacement, which can hardly be eliminated by conventional doping or coating strategies and result in accelerated performance decay. Herein, we incorporate a strain-inhibiting perovskite phase coherently grown within the layered structure to effectively restrain the displacement and lattice strain during uneven Li-ion extraction.

Study on hsa_circ_101209 in Plasma of Pregnant Women with Deep Venous Thrombosis.

Background: This study analyzed the expression and diagnostic value of hsa_circ_101209 in plasma of pregnant women with in deep vein thrombosis (DVT).

Methods: By circRNA microarray detection and GO/KEGG analysis, hsa_circ_14797 targeting miRNA-mRNA network was predicted. Sixty women with DVT were selected as the DVT group, and 60 women without DVT as the non-DVT group.

A bibliometric analysis of the development trend of Tuina research: Based on the Web of Science (WOS) platform.

Background: Tuina has been proven to significantly relieve symptoms, demonstrating its clinical value. With the growth of related research, a comprehensive review is urgently needed to promote its development. This study aims to clarify the collaboration and current research status in the field of Tuina research using bibliometric analysis, and to discuss future directions.

A novel small molecule NJH-13 induces pyroptosis via the Ca driven AKT-FOXO1-GSDME signaling pathway in NSCLC by targeting TRPV5.

Introduction: Pyroptosis represents a mode of programmed necrotic cell death (PCD), mediated by members of gasdermin family (GSDMs), such as GSDME. It is emerging as a promising approach for combating cancer. Notably, GSDME is the key modulator for the switch between apoptosis and pyroptosis in cells.

Internet use and social trust: empirical analysis based on CGSS2021.

The development of the Internet has significantly changed the way people live and interact with each other. Interaction is the foundation for building trust and may therefore also be influenced by the Internet. This study aims to examine the impact of Internet use on different dimensions of social trust, focusing on the roles of perceived fairness and social support, using the latest data from the CGSS from China.

Non-invasive ML methods for diagnosis of congenital heart disease associated with pulmonary arterial hypertension.

Objective: Congenital heart disease with pulmonary arterial hypertension (CHD-PAH), caused by CHD, is associated with high clinical mortality. Hence, timely diagnosis is imperative for treatment.

Approach: Two non-invasive diagnosis algorithms of CHD-PAH were put forward in this review, which were direct three-divided and two-stage classification models.

Role of mitochondrial complex I genes in host plant expansion of Bactrocera tau (Tephritidae: Diptera) by CRISPR/Cas9 system.

Host expansion facilitates tephritid flies to expand their ranges. Unraveling the mechanisms of host expansion will help to efficiently control these pests. Our previous works showed mitochondrial complex I genes Ndufs1, Ndufs3, and Ndufa7 being upregulated during host expansion of Bactrocera tau (Walker), one of the highly hazardous species of tephritids.

Ecological risk assessment and response prediction caused by LUCC in the central Yunnan Province.

With the acceleration of urbanization, unreasonable land use poses a serious threat to ecological security. However, there is still some space for improvement in the existing assessment of ecological risks (ERs) caused by land use/land cover change (LUCC). Therefore, this study takes the central Yunnan Province (CYP) as an example, and uses the Patch-Generating Land Use Simulation (PLUS) model and the Integrated Valuation of Ecosystem Services and Trade-offs (InVEST) model to simulate the land use/land cover (LULC) in different scenarios in the future, calculate the ecosystem services (ESs) from 2000 to 2020 and the next 20 years, as well as ERs of various types of ESs caused by LUCC.