1,092 results match your criteria: "Yunnan University of Chinese Medicine[Affiliation]"

Background: The pathophysiology of liver diseases is significantly influenced by oxidative stress, making its alleviation a key strategy for treatment. The Keap1/Nrf2 signaling pathway is the body's most crucial antioxidant defense mechanism. Traditional Chinese medicine, Desmodium heterocarpon (L.

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Declining trends and regional variations of organophosphate ester contamination in indoor dust from mainland China: Insights from a filed study and meta-analysis.

Sci Total Environ

December 2024

College of Environment and Climate, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China.

This study investigated the presence of 20 organophosphate esters (OPEs) in indoor dust samples collected from the Chinese cities of Lanzhou, Xining, and Lhasa. The results demonstrate the ubiquitous presence of most OPEs in these three cities, with the highest concentrations of ΣOPEs found in Xining. We also summarized the occurrence of OPEs in indoor environments from 38 studies with 1875 samples collected across various regions of mainland China from 2012 to 2023.

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Xuanhong Dingchuan Tang suppresses bronchial asthma inflammation via the microRNA-107-3p/PTGS2/MAPK axis.

Funct Integr Genomics

December 2024

Department of Pediatrics and Department of Integrative Medicine on Pediatric, The First Hospital Affiliated Yunnan University of Chinese Medicine, 120 Guanghua Road, Kunming, Yunnan, 650021, China.

This study aimed to investigate the mechanism of Xuanhong Dingchuan Tang (XHDCT) in delaying bronchial asthma inflammation via the microRNA (miR)-107-3p/prostaglandin endoperoxide synthase 2 (PTGS2)/mitogen-activated protein kinase (MAPK) axis. Based on the network pharmacological analysis, XHDCT chemical constituents and targets of each chemical constituent were screened through the TCMSP database, and differential-expressed genes of bronchial asthma were obtained from the GEO database, which were intersected to get XHDCT potential anti-inflammatory targets. The key anti-inflammatory targets of XHDCT were acquired by protein-protein interaction (PPI) analysis of the candidate targets.

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Purpose: This study aims to provide healthcare providers with insights into relevant interventions by examining the timing, format, content, outcome measures, and effects of clown care interventions on hospitalized children.

Methods: This study utilized a scoping review methodology based on the framework by Arksey and O'Malley. The search for Chinese and English literature on the utilization of clown care for hospitalized children was conducted in databases including CNKI, VIP, Wanfang, China Biology Medicine Database, PubMed, Embase, Web of Science, CINAHL, and Cochrane Library.

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Background: Zhuanggu Shubi ointment (ZGSBG) has good efficacy in postmenopausal osteoporosis (PMO), but the mechanism of efficacy involving gut microecology has not been elucidated.

Objective: This study investigated the mechanism of ZGSBG in regulating gut microecology in PMO.

Methods: The bilateral ovarian denervation method was used to construct a rat model of PMO and was administered ZGSBG.

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Ethnopharmacological Relevance: Positive deficiency and cancer toxicity are the main pathogenesis of colorectal cancer (CRC) lung metastasis. Yanghe decoction (YHD), a traditional Chinese medicine, has the effects of warming yang, tonifying blood, dispersing cold and clearing stagnation, adopting a treatment method that combines supporting the right and dispelling the wrong, which has remarkable efficacy in anti-tumor.Although, its precise mechanism of inhibiting the metastasis of colorectal cancer to the lung is still poorly understood.

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Fe-Doped 4-Aminophenylacetylene-Derived Red Emissive Polymer Carbon Dots: Synthesis and Anti-Counterfeiting Applications.

ACS Appl Mater Interfaces

December 2024

National Joint Engineering Research Center for Highly-Efficient Utilization Technology of Forestry Resource, Southwest Forestry University, Kunming 650224, P. R. China.

Phenylacetylene derivatives serve as typical monomers for polyaddition reactions. In this study, we present a straightforward one-step protocol for synthesizing polyacetylene P0 (undoped), P0.09 (doped with 0.

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Global research trends in the relationship between influenza and CD4 T/CD8 T cells: A bibliometric analysis.

Hum Vaccin Immunother

December 2024

Center for Xin'an Medicine and Modemization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei, China.

Influenza pathogens cause many illnesses and deaths yearly, posing a serious threat to global public health. As a result, most studies are increasingly focusing on the role of specific CD4 T/CD8 T cells in combating influenza. This study examines the key themes and trends in this field using bibliometric analysis.

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Objective: This systematic review and meta-analysis aimed to evaluate the efficacy of combination scalp acupuncture in treating post-stroke cognitive impairment.

Methods: A comprehensive search was conducted across eight databases: PubMed, Web of Science, Cochrane Database, Embase, CBM, CNKI, WanFang, and VIP, targeting randomized controlled trials (RCTs) published from the inception of these databases until October 24, 2024. The inclusion criteria focused on RCTs that compared scalp acupuncture with conventional treatments as therapeutic interventions for patients suffering from post-stroke cognitive impairment (PSCI).

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Background: The glomerular injury is associated with different pathogeneses, and podocyte damage is common in various ISN/RPS class lupus nephritis (LN). In podocyte, mitochondrial morphological changes are observed in lupus nephritis (LN) in our previous study. This study aimed to explore mitochondrial fission proteins expression in podocytes using bioinformatics analysis and further to investigate the associations between mitochondrial fission proteins and laboratory features in LN.

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Osteoarthritis (OA) is a condition that is widely prevalent and causes joint pain and disability, with programmed cell death (PCD) playing a role in its pathogenesis. This study aimed to identify biomarkers associated with PCD in OA and explore their potential roles. Three RNA-sequencing datasets (GSE114007, GSE51588 and GSE220243) related to OA were analysed.

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Voagafries A-E, undescribed indole alkaloids with anti-glioma activity from Voacanga africana.

Phytochemistry

December 2024

School of Pharmaceutical Science & Yunnan Provincial Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, China; Yunnan College of Modern Biomedical Industry, Kunming Medical University, Kunming, 650500, China. Electronic address:

Voagafries A-E, five undescribed monoterpenoid indole alkaloids (MIAs), were isolated from the stem bark of Voacanga africana. Voagafrie A (1) has a unique 6/5/5/6/6 spiral ring skeleton with an indolone-fused 9-oxo-3-aza-tricyclo[6,3,1,0]-12-alkane-10-carbonyllactone. Voagafrie B (2) is a rare 5,6-seco diazine scaffold, whereas voagafrie C (3) possesses an octahydropyrrolo[2,3-b] pyrrole-fused 2,8-diazabicyclo[3.

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The natural bicyclic sesquiterpene, β-Caryophyllene oxide (BCPO), has demonstrated inhibitory activity against Fusarium species. While previous studies have documented its antifungal properties through various biochemical mechanisms, the role of BCPO in modulating epigenetic modifications of DNA via histone deacetylases (HDACs) has received comparatively less attention. The study aims to elucidate how BCPO inhibits Fusarium proliferatum by affecting histone acetylation.

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Objective: This study aimed to evaluate the effects of a therapeutic lifestyle modification (TLM) intervention on health-related quality of life, sexual functioning and cardiometabolic health in perimenopausal Chinese women.

Method: The study was a randomized controlled trial (registration number: ChiCTR2300070648). Ninety-four perimenopausal women aged between 40 and 55 years were randomly assigned in a 1:1 ratio to receive the TLM intervention or usual care for 12 weeks.

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Background: Chronic viral infections, such as Human Immunodeficiency Virus (HIV), and their reactivation are considered potential contributing factors to Long-Corona Virus Disease (LC). However, research on the long-term sequelae of Long-COVID in individuals with HIV is limited.

Methods: We conducted a case-control study involving a total of 84 participants categorized into two groups: people living with HIV (PLWH) and people not living with HIV (PNLWH) within the six-month post-infection LC population.

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Unlabelled: Patchouli oil (PO), extracted from Benth., a prominent aromatic plant of the Lamiaceae family, has shown considerable protective effects against gastrointestinal infections, particularly those induced by . This study aimed to develop a gastro-floating multi-unit system for PO to enhance its gastric retention and oral bioavailability.

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This study aimed to investigate the efficacy and safety of fire needle plus cupping (FC) combined with oral famciclovir and gabapentin for the treatment of acute-phase herpes zoster (AHZ). This study was conducted as a superiority, randomized controlled trial in which 84 patients with AHZ who met the diagnostic criteria were selected and randomly assigned to three groups on a 1:1 basis. Group A: received oral famciclovir with gabapentin treatment (FG); Group B: received fire needle plus cupping (FC) with FG.

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Background: Aromatherapy has been proposed as a complementary therapy to enhance sleep quality and regulate mood. However, few studies have specifically examined the efficacy of aromatherapy in managing sleep disorders in older adults. Therefore, the present study aims to systematically review the impact of aromatherapy on sleep quality among older adults.

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Evaluation of the sedative-hypnotic effects of Menyanthes trifoliata L. extract in mice.

J Ethnopharmacol

December 2024

School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, 650500, China; Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Yunnan University of Chinese Medicine, Kunming, 650500, China. Electronic address:

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Wolfberry (Lycium barbarum) glycopeptide attenuates dopaminergic neurons loss by inhibiting lipid peroxidation in Parkinson's disease.

Phytomedicine

November 2024

Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility/Guangzhou Key Laboratory of Traditional Chinese Medicine &Disease Susceptibility/Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Engineering Research Center of Traditional Chinese Medicine & Health Products/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/State Key Laboratory of Bioactive Molecules and Druggability Assessment/The Sixth Affiliated Hospital, Jinan University, Guangzhou 510632, China; School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming 650500, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China. Electronic address:

Background: Parkinson's disease (PD) is a common neurodegenerative disorder characterized clinically by motor dysfunction due to gradual loss of dopaminergic neurons in the nigrostriatal system. Currently, medications such as levodopa preparations, offer only temporary symptomatic relief without preventing neuronal loss or halting disease progression. In traditional Chinese medicine (TCM), a particular type of wolfberry or goji berry, the fruit of Lycium barbarum L.

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As a pathological feature of diabetic kidney disease (DKD), dysregulated glomerular filtration barrier function could lead to the increased levels of proteinuria. The integrity of tight junctions (TJs) of glomerular endothelial cells (GECs) is a guarantee of physiological function of glomerular filtration barrier. Mammalian sterile 20-like kinase (MST1) is a key regulatory protein in the blood-brain barrier (BBB), and it regulates the expression of TJs-related proteins in cerebral vascular endothelial cells.

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Two new sesquiterpenol caffeates from Bauhinia brychycarpa Wall. ex Benth. and their α-glucosidase inhibitory activity.

Fitoterapia

December 2024

School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China; Yunnan College of Modern Biomedical Industry, Kunming 650500, PR China. Electronic address:

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Characterization of Spirobisnaphthalenes from an Endophytic Fungus sp. Associated with and Insights into Their Biological Activity.

J Agric Food Chem

December 2024

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650500, China.

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Establishment of a standardized daily behavior collection and analysis system for brain disease models of rhesus and cynomolgus monkeys and its application in autism spectrum disorder.

J Zhejiang Univ Sci B

November 2024

National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Genetic Evolution & Animal Models, National Resource Center for Non-human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650107, China.

Article Synopsis
  • Complex brain diseases pose significant health risks, and there's a need for early diagnostic tools and treatments, which human research limitations hinder.
  • To overcome ethical research barriers, transgenic monkey models, particularly for autism spectrum disorder (ASD), have been created to study these diseases.
  • A standardized system for tracking and analyzing daily behaviors of these monkey models has been developed, enabling quantitative assessment of ASD symptoms through a new specific behavior ethogram.
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