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Biotransformation of α-terpineol by .

RSC Adv

February 2020

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, School of Chemical Science and Technology, Yunnan University Kunming 650091 P. R. China

α-Terpineol (1), the main volatile constituent in some traditional Chinese medicines, has been reported to be metabolized to 4-oleuropeic acid by the larvae of common cutworms. The present study verified that α-terpineol could be converted to 4-oleuropeic acid (2) and (1,2,4)--menthane-1,2,8-triol (3) by fermentation. Using shortened fermentation times, 7-hydroxy-α-terpineol (2a) was identified as an oxidative intermediate, which was consistent with the hypothesis put forward by previous studies.

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