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Article Synopsis
- Immune checkpoint inhibitors (ICI) show promise for treating advanced colorectal cancer (CRC), especially in patients with deficient mismatch repair (dMMR) and high microsatellite instability (MSI-H), but have limited effectiveness in proficient mismatch repair (pMMR) cases.
- A 57-year-old man with pMMR MSS IVb CRC and liver metastasis switched from traditional treatments to an investigational approach that included anti-PD-1, anti-VEGF, and fecal microbiota transplantation (FMT) capsules after experiencing severe side effects.
- This combination therapy led to a significant reduction in tumor size, allowing for successful surgical resection and achieving a pathological complete response (pCR), suggesting that FMT could potentially