Exploring the GSTP1 inhibition potential of photosensitizer compounds for enhanced cancer treatment in photodynamic therapy.

Photodynamic therapy (PDT) has gained considerable attention in cancer treatment due to its non-invasive nature and the ability of photosensitizers to generate reactive oxygen species upon light activation, leading to tumor destruction. Glutathione S-transferase P1 (GSTP1) is a key enzyme in chemotherapy resistance, often overexpressed in various cancers, and its inhibition of GSTP1 presents a promising strategy to enhance cancer treatment. This study is aimed at assessing the potential of prominent photosensitizers as GSTP1 inhibitors through molecular docking analysis to strengthen the efficacy of PDT.

Periprosthetic joint infections: state-of-the-art.

In general, periprosthetic joint infection (PJI) is regarded as one of the most common complications of total joint arthroplasty (TJA) and may lead to surgical failure, revision surgery, amputation or death. Nowadays, PJI has become a global health concern, which brings a great burden to public healthcare. In addition, there are still obstacles to achieve high success rates in the prevention, diagnosis and treatment of PJI.

Comparison of screw fixation and dynamic fixation in the treatment of ankle fractures with syndesmotic ruptures.

Background: Syndesmosis injuries in ankle fractures can significantly impact patient mobility and recovery, making the choice of fixation method crucial for optimal outcomes. This study aimed to compare the quality of reduction and functional results between screw fixation and dynamic fixation in treating syndesmosis injuries in ankle fractures.

Methods: This cohort study included 48 patients (28 males, 20 females) with an ankle fracture accompanied by syndesmosis injury.

The Triglyceride-Glucose Index as a Marker in Idiopathic Restless Legs Syndrome.

Background and objective Restless legs syndrome (RLS) is more common in diabetic patients than in the general population. In this study, we aimed to explore the association between idiopathic RLS and the triglyceride-glucose (TyG) index, which is a simple and accessible marker of insulin resistance (IR). Materials and methods The study included 200 patients diagnosed with RLS according to the International Restless Study Group criteria, as well as 112 healthy volunteers.

Trauma levels and perspectives on dignified death among nurses and physicians who directly experienced the recent earthquake.

Background: Unexpected, sudden, and tragic losses can prompt us to reflect on the concept of a "good death." The earthquake disaster that struck our country in 2023 vividly demonstrated the challenging impact of such events, which can turn lives upside down and compel us to question the notion of a "good death." This study aims to determine the perceptions of a "good death" and the levels of trauma experienced by physicians and nurses who directly witnessed the earthquake disaster, and to understand the relationship between these factors.

Relationship between soft tissue envelope thickness of the lower extremity and acute periprosthetic joint infection of the knee.

Background: The prevalence of obesity is increasing worldwide and it is known to be associated with many postoperative complications, including infection. Patients' body fat distribution may vary and body mass index (BMI) does not provide sufficient information about adipose tissue thickness of the lower extremities. The aim of this study is to investigate the relationship between thigh diameters and early postoperative prosthesis-related joint infections (PJI) in patients who underwent arthroplasty.

The effect of proprioceptive vestibular rehabilitation on sensory-motor symptoms and quality of life.

Background:  Peripheral vestibular hypofunction (PVH) is characterized by balance and gait disorders and vestibulo-autonomic findings. The vestibular system and proprioceptive system work together to regulate sensorimotor functions. Vestibular exercises are effective in PVH, but their superiority over each other is still unclear.

The Interactions of Resveratrol and Sodium Valproate on Penicillin-Induced Epilepsy Model: Electrophysiological and Molecular Study.

Epilepsy represents the most prevalent chronic neurological disease, characterized by spontaneous recurrent seizures. In experimental epilepsy models created by different methods, resveratrol has been demonstrated to reduce epileptiform activity and exhibit neuroprotective properties. A penicillin-induced model of epileptogenesis was used to investigate the effects of resveratrol and its combination with sodium valproate on epileptiform activity.

The effect of lullaby played to preterm infants in neonatal intensive care units on physiological parameters and pain.

Purpose: The study was conducted as a randomized controlled experimental study to investigate the effects of music therapy application on physiological parameters and pain in preterm infants."

Materials And Methods: Preterm newborns included in the study were divided into 3 groups. The first group is experiment I, in which lullabies sung by the babies' own mothers were recorded and played.

Investigation of endoplasmic reticulum stress-regulated chaperones as biomarkers in idiopathic nonobstructive azoospermia.

Azoospermia is a condition in which sperm cells are completely absent in a male's ejaculate. Typically, sperm production occurs in the testes and is regulated by a complex series of cellular and molecular interactions. Endoplasmic reticulum (ER) stress arises when there is a deviation from or damage to the normal functions of the ER within cells.

Are smartphones a tool to cope with the fear of childbirth? The correlation between the fear of loss of connection and the fear of childbirth.

Objective: With the spread of smartphones, they have become an indispensable part of life, and nomophobia (No-Mobile-Phone Phobia) has emerged.

Methods: The present research is a cross-sectional study and was conducted with 3,870 primiparous pregnant women between April and May 2022. The research data were collected using the Personal Information Form, Nomophobia Questionnaire, and Wijma Delivery Expectancy/Experience Questionnaire.

The Effects of Foam Rolling at Different Speeds on Mechanical Properties of Quadriceps Femoris.

Foam rolling have gained popularity among elite athletes, but the effect of the speed parameter of foam rolling has not yet been determined. Our objective was to investigate the impact of different application speeds of foam roller on the mechanical properties of the quadriceps femoris muscle. Eighteen male professional basketball athletes (age 23 ± 4 years, body mass index 24.

The invisible connection of mothers' BMI, emotional appetite, and food choices with childhood obesity.

Background: This study examined the effects of mothers' body mass index (BMI), emotional appetite, and food choices on children's growth curves and adiposity.

Methods: Data was collected from 492 mothers. The demographic characteristics and anthropometric measurements were obtained using a questionnaire.

Mothers' phubbing behaviors and parental role: A cross-sectional correlational study.

Objective: This study was conducted to determine the relationship between mothers' phubbing behaviors and the parental role.

Methods: The study was conducted as a cross-sectional correlational design with the mothers of 340 babies hospitalized in the pediatric clinics of a training and research hospital in Çorum between March 2023 and September 2023. An introductory information form, the Generic Scale of Phubbing and the Self-Perception of Parental Scale were used in the study.

Looking backward toward the future: A bibliometric analysis of the last 40 years of meningioma global outcomes.

This study is the first comprehensive bibliometric analysis about meningioma to date. The aim of this study is to identify the most influential publications in this field through citation and co-citation analysis, to examine international collaborations, to identify the conceptual framework of the subject and emerging trending topics through keyword analysis, and to identify the most productive countries, authors and journals. 9619 articles on meningioma published between 1980 and 2023 were downloaded from the Web of Science (WoS) database and statistically analyzed.