1,358 results match your criteria: "Yuksek Ihtisas Training and Research Hospital[Affiliation]"

Objectives: Congenital syphilis can cause severe morbidities such as hydrops fetalis, preterm birth, low birth weight, hepatosplenomegaly, pneumonia, hypoglycemia, etc., and mortality. Despite hypoglycemia being reported in congenital syphilis and hyperinsulinism, only one case was described.

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: The optimal choice of cardioplegia solution in minimally invasive cardiac surgeries (MICS) remains debated, as prolonged myocardial protection is essential to avoid interruptions to the surgical flow, which can prolong aortic cross-clamp time and cardiopulmonary bypass time, especially in the constrained surgical field. We conducted a network meta-analysis to evaluate the safety and efficacy of the del Nido (DN), histidine-tryptophan-ketoglutarate (HTK), blood cardioplegia (BC), and St. Thomas' (STH) solutions in MICS.

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  • Previous studies on the use of serial prolactin (PRL) measurements for diagnosing mild hyperprolactinemia (HP) have shown mixed results, prompting this study to explore their effectiveness alongside a new method called the prolactin decrease rate (PDR).
  • Analysis of medical records from 221 patients showed that 153 had mild HP and demonstrated that serial PRL measurements were less effective at detecting HP compared to single measurements, while the PDR provided additional specificity for diagnosis.
  • The study concluded that combining serial PRL measurements with the PDR is a more reliable approach for diagnosing prolactinoma and HP when clinical symptoms are unclear.
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New biological markers in diagnosis and follow-up of brucellosis cases.

Diagn Microbiol Infect Dis

February 2025

Department of Immunology, Bursa Uludag University Faculty of Medicine, Bursa, Turkey. Electronic address:

Brucellosis remains a significant public health issue in some parts of the world. It is clear that new laboratory methods are needed to diagnose brucellosis. Currently, no test method meets the criteria of high specificity, sensitivity, reliability, and low cost for the diagnosis of brucellosis, which could also predict chronicity.

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  • This study focuses on improving the diagnostic accuracy of MRI in identifying prostate cancer lesions before biopsies, aiming to understand independent risk factors influencing biopsy results.
  • An analysis of 364 patients showed that while certain MRI parameters (like PI-RADS scores and ADC values) are helpful in distinguishing cancer from benign conditions, they do not effectively predict clinically significant prostate cancer.
  • The only strong predictor for clinically significant prostate cancer was the total prostate-specific antigen (PSA) level, indicating its importance in the diagnostic process.
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Objective: The mechanism behind prolactin (PRL) elevation in stress-induced hyperprolactinemia (si-HP) in humans is unclear. This study aimed to investigate the effect of psychological stress and venous puncture (VP) pain on si-HP.

Methods: The study included 91 individuals (9 males, 82 females) referred for HP.

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: Secukinumab is a monoclonal antibody against interleukin 17 approved for patients with axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), and psoriasis. Treating axSpA and PsA patients with a history of malignancy is a challenge. While initial results on the applicability of secukinumab in this patient group are positive, the number of studies on this topic remains limited.

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Aim: This study aims to evaluate the reliability and validity of the Turkish version of the Standard Assessment of Global Everyday Activities (SAGEA) scale in older adults.

Methods: The study employed a cross-sectional, methodological design. The SAGEA scale was administered twice, with a two-week interval for test-retest reliability.

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Atrial fibrillation in elderly patients with severe aortic stenosis.

Kardiol Pol

October 2024

University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Department of Cardiovascular Surgery, Mimar Sinan Town. Emniyet Street. Yıldırım/BURSA, Turkey.

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Article Synopsis
  • Ocrelizumab (OCR) shows effectiveness in treating multiple sclerosis (MS) but can lead to a "wearing-off phenomenon" (WoP) prior to infusions.
  • A study involving 409 MS patients found that a substantial number experienced WoP symptoms, with many reporting issues like fatigue and walking difficulties four weeks before their next dose.
  • Factors such as shorter disease duration and longer intervals between doses were associated with increased WoP occurrence, indicating a need for more personalized treatment approaches.
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: Metabolic dysfunction-associated steatotic liver disease (MASLD) and polycystic ovary syndrome (PCOS) share several pathophysiological mechanisms. While the prevalence of MASLD has been extensively studied in PCOS populations, the occurrence of PCOS among female adolescents with transient elastography (TE)-confirmed MASLD in pediatric hepatology settings remains poorly characterized. This cross-sectional study aims to address this knowledge gap and elucidate potential clinical and biochemical differences between female adolescents with MASLD and comorbid PCOS compared to those without PCOS.

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  • The study evaluated the effects of laser therapy combined with splints and exercise on patients with cubital tunnel syndrome (CuTS) compared to a placebo treatment.
  • A total of 64 patients were randomly divided into two groups, one receiving actual laser therapy and the other receiving sham laser therapy, alongside standardized treatments like splints and exercises.
  • Results showed significant short-term improvements in pain and function for the laser therapy group compared to the placebo, but both groups had similar medium-term effects, suggesting the need for more research with larger sample sizes.
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The Relationship Between the Modified Glasgow Prognostic and SYNTAX Scores in Patients with Non-ST Elevation Myocardial Infarction.

Medeni Med J

September 2024

University of Health Sciences Türkiye, Kartal Kosuyolu Yuksek Ihtisas Training and Research Hospital, Clinic of Cardiology, Istanbul, Türkiye.

Objective: This study investigated the modified Glasgow prognostic score (mGPS) to determine its predictive value and how it could be compared with various inflammatory markers, including C-reactive protein (CRP) to albumin ratio and neutrophil-to-lymphocyte ratio, for determining the extent and severity of coronary artery disease (CAD) in patients with non-ST-elevated myocardial infarction (NSTEMI).

Methods: This study analyzed the cases of 295 patients with NSTEMI who had undergone coronary angiography. In an effort to determine the seriousness and scope of CAD in each patient, the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score was calculated and then assessed.

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Article Synopsis
  • * Among 106 patients, 83 had CN, and those who had the surgery could continue their nivolumab treatment for longer (14.5 months) compared to those who didn't have the surgery (6.7 months).
  • * Overall survival was better for patients with CN (22.9 months) compared to those without it (8.1 months), but the surgery and certain medical scores were important factors for how long they lived.
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Erectile dysfunction (ED) is one of the most common complaints in the male sexual health field, with a multifactorial etiology yet to be fully elucidated. Nucleobindin 2 (NUCB2)/nesfatin-1, known for its regulatory role in food intake, can also regulate the vascular, neural and hormonal systems, all of which are of great importance in the etiology of ED. The present study included 43 men with ED and 40 healthy individuals without ED.

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  • * A study in Turkey examined the responses of 17 patients with solid tumors and NTRK fusions who received entrectinib, revealing a median age of 42 years and various types of cancer, with NTRK1 and NTRK3 being the most common gene rearrangements.
  • * Results showed a 35.3% objective response rate with side effects leading to dosage reductions in four patients; the median overall survival was 20.8 months
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Background: TTE is the main modality used to assess RV function, but conventional TTE parameters have limited diagnostic value because they may fail to detect early abnormalities in RV systolic function. Due to its ability to detect subclinical impairment of cardiac function, 2D STE has been widely used to investigate RV function. In this study, we aimed to investigate whether there are sequelae of RV function in recovered COVID-19 patients with pulmonary involvement.

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  • This study aimed to compare the effectiveness and postoperative complications of two treatment methods (laser vs. hybrid seton) for perianal fistulas in 76 patients over a period from January 2021 to April 2022.
  • The results indicated that while the laser method had fewer complications, it also had a higher treatment failure rate and lower patient satisfaction compared to the hybrid seton method.
  • Ultimately, the hybrid seton method showed better overall outcomes in terms of patient satisfaction and lower rates of fecal incontinence despite having more complications.
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Objectives: In the era of artificial intelligence, almost half of the patients use the internet to get information about their diseases. Our study aims to demonstrate the reliability of the information provided by artificial intelligence chatbots (AICs) about urogenital cancer treatments.

Methods: The most frequently searched keyword about prostate, bladder, kidney, and testicular cancer treatment via Google Trends was asked to 3 different AICs (ChatGPT, Gemini, Copilot).

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Aim: To investigate the radial peripapillary capillary plexus vessel density (RPCP-VD) and peripapillary retinal nerve fiber layer thickness (pRNFLT) of systemic lupus erythematosus (SLE) and neuropsychiatric SLE patients (NPSLE) using disc optical coherence tomography angiography (OCTA) and investigate the association between these parameters and SLE disease activity index (SLEDAI-2K).

Methods: A total of 64 'right eyes (36 SLE patients, 28 healthy controls (HCs)) were included in this cross-sectional case-control study. Ten (27.

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Aortic floating thrombus and COVID‑19.

Gen Thorac Cardiovasc Surg

January 2025

Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Mimar Sinan Town, Emniyet Street, Yıldırım, Bursa, Turkey.

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