Silymarin protected the cerebral tissue from endoplasmic reticulum stress.

Background: Our aim is to explore silymarin's protective effects against endoplasmic reticulum (ER) stress via protein kinase R-like endoplasmic reticulum kinase (PERK) modulation and elucidate potential enriched pathways through in silico analysis of silymarin-associated PERK protein interactors in cerebral ischaemia-reperfusion (IR) injury.

Materials And Methods: 30 rats were categorized into three groups: sham, IR and IR + silymarin groups. Cerebral IR damage was not induced.

Clinical Features and Natural Course of Hidradenitis Suppurativa in Turkey: A Multicenter Study.

Introduction: The natural history, the progression of a disease process in an individual over time, has not yet been fully elucidated in hidradenitis suppurativa (HS). In this large multicenter study, we aimed to investigate the natural history of HS and its gender differences.

Methods: This cross-sectional study included 827 patients.

Antioxidant Activity, Total Phenolic Content, and Volatile Component Profiles of Propolis From Eight Turkish Regions.

This study aimed to evaluate the volatile component profiles and antioxidant activities of propolis samples collected from eight regions of Türkiye. The total phenolic content of propolis samples was found to vary between 5333 and 36967 mg GAE/100 g. 2,2-Diphenyl-1-picrylhydrazyl radical scavenging activity of the samples varied from 10.

New approaches in pear preservation: Putrescine and modified atmosphere packaging applications to maintain fruit quality during cold storage.

Pear ( L.), which is a climacteric fruit species, has a very short storage and shelf life, and significant losses occur due to high metabolic activity and the fruit's respiration rate after harvest. Therefore, preventing or reducing post-harvest quality losses in pear is one of the most basic problems awaiting solution.

Effects of Chlorella sp. and Schizochytrium sp. extracts on growth indices, body composition, and gene expression profiles in rainbow trout (Oncorhynchus mykiss).

This study assessed the impact of dietary Chlorella sp. and Schizochytrium sp. extracts on growth performance, feed utilization, body composition, and gene expression related to growth, digestion, antioxidant defense, and immune response in rainbow trout (Oncorhynchus mykiss).

Effects of 1800 MHz and 2100 MHz mobile phone radiation on the blood-brain barrier of New Zealand rabbits.

In this study, the impact of mobile phone radiation on blood-brain barrier (BBB) permeability was investigated. A total of 21 New Zealand rabbits were used for the experiments, divided into three groups, each consisting of 7 rabbits. One group served as the control, while the other two were exposed to electromagnetic radiation at frequencies of 1800 MHz with a distance of 14.

New targets and biomarkers for doxorubicin-induced cardiotoxicity in humans: implications drawn from toxicogenomic data and molecular modelling.

The doxorubicin-induced cardiotoxicity continues to be a life-threatening adverse effect in the clinic. Doxorubicin-induced acute cardiotoxicity is reversible, whereas chronic cardiotoxicity is irreversible, leading to dilated cardiomyopathy and heart failure. The aim of this study was to identify the molecular mechanisms associated with doxorubicin metabolites in doxorubicin-induced chronic cardiotoxicity.

Comparison of the analgesic efficacy of spray and tablet flurbiprofen for pain after soft tissue surgery.

The aim of this randomized clinical study was to assess the comparative efficacy of flurbiprofen in tablet and spray formulations for postoperative pain management in oral soft tissue wounds undergoing primary closure while investigating the feasibility of achieving optimal analgesia with reduced dosage and risk. Forty patients who underwent epulis fissuratum and frenulum excision for pre-prosthetic surgery were randomly assigned to receive either tablet or spray forms of flurbiprofen. The lesion dimensions were measured preoperatively, followed by excision and primary closure.

Comparative study in distal hypospadias repair: a meatal-based flaps technic vs. tubularized incised plate urethroplasty.

Objectives: Hypospadias is the most common anomaly of the male genital system after undescended testis. More than 200 surgical repair techniques have been described for the treatment of hypospadias due to many different meatus localisations and other accompanying anomalies. Kutlay defined a new technique in 2010 with 10 patients with distal hypospadias patients.

Efficacy of Infliximab in Experimental Tracheal Stenosis.

Objective: This study aimed to investigate the efficacy of infliximab, a TNF-α inhibitor, on epithelial damage, inflammation, and fibrosis in experimental tracheal stenosis.

Methods: Rats were divided into 3 groups. In group 1 (the control group), no procedure was applied.

Cytotypes in Some Regions of Türkiye.

A new hexaploid cytotype of has been identified in Türkiye. To assess the ploidy levels of native populations, 50 samples from Adıyaman, Batman, Bitlis, Diyarbakır, Hakkari, Mardin, Siirt, Şanlıurfa, Şırnak, and Van were analyzed using flow cytometry and cytogenetic techniques. DNA content was determined by comparison with standard plants.

Bee venom and melittin: Potent key enzyme inhibitors with promising therapeutic potential.

Bee venom (BV) is a versatile product with extensive applications, boasting antibacterial and anticancer properties. Within this study, we focused on isolating melittin (Mel) from Apis mellifera L. venom and exploring the influence of both BV and Mel on specific enzymes, namely carbonic anhydrase (CA) I, CA II, CA IX, glutathione reductase (GR), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and neuraminidase (NA).

Enhancing the content of phycoerythrin through the application of microplastics from Porphyridium cruentum produced in wastewater using machine learning methods.

Microalgae can produce secondary metabolites like phycoerythrin (Phy). The effects of some microplastics (MPs), wastewater (WW), and light intensity (LI) parameters, including complex data sets, on Phy concentration from Porphyridium cruentum were investigated using machine learning methods in this study. Also, the deep learning (DL) model was developed to get the maximum phy concentration from the dataset.

Regional variations in psoriatic arthritis: Insights from a nationwide multicenter analysis in Türkiye.

Objectives: The study aimed to investigate and compare clinical features, disease activity, and the overall disease burden among psoriatic arthritis (PsA) patients across seven distinct geographic regions in Türkiye.

Patients And Methods: A multicenter cross-sectional study involving 1,134 PsA patients from 25 referral centers across seven regions was conducted. Demographic and clinical characteristics, comorbidities, joint involvement, extra-articular manifestations, and disease activity measures were evaluated across regions.

Organ toxicities associated with diet-induced obesity in rats: Investigation of changes in activities selected enzymes.

Obesity stands out as one of the most significant health problems in the modern world. The prevalence of high-calorie diets (HCDs) globally exacerbates this condition. Throughout history, plants and plant-derived food products have been utilized for medicinal purposes, demonstrating their efficacy in the treatment and prevention of various diseases.

Do we need a guideline for all: a qualitative study on the experiences of male athletes following anterior cruciate ligament reconstruction.

Background: Considering the low rate of qualitative studies on athletes with anterior cruciate ligament reconstruction (ACLR), aiming to access in-depth data, we thought that the utilization of the qualitative method would allow us to collect the appropriate and sufficient data to yield novel findings and achieve sound conclusions. The study's aim was to investigate anterior cruciate ligament (ACL) injury experience processes in athletes who had undergone isolated ACLR, reveal the clinically related milestones, and highlight the necessary gaps.

Methods: Semi-structured interview techniques, in-depth follow-up questions, and thematic analysis were used to explore the experiences of participants with isolated ACL injuries 1-3 years after surgical treatment.

Effects of Housing Systems on Production Performance, Egg Quality, Tonic Immobility and Feather Score in Laying Hens.

Background: This study was designed to investigate the effects of different housing systems on production performance, egg quality and welfare in laying hens.

Methods: One hundred and twenty 42-week-old "Atak S" laying hens, purchased from a manufacturing company, were randomly assigned to 4 housing systems: conventional cages, furnished cages, deep-litter system and free-range. Each system housed 30 hens, which were kept in these systems for 6 weeks.

Effect of Telerehabilitation-Based Motor Imagery Training on Pain and Related Factors in People With Multiple Sclerosis: Randomized Controlled Pilot Trial.

Objectives: To investigate the effect of telerehabilitation-based graded motor imagery (MI, GMI) training on pain and pain-related factors in people with multiple sclerosis (MS).

Design: Randomized controlled, assessor-blind pilot trial with repeated-measure design.

Setting: Neurology outpatient clinic.

Identification of volatile compounds and evaluation of certain phytochemical properties of Turkish propolis.

The purpose of this study was to assess volatile component profiles and the antioxidant activity of propolis samples from eight different locations in Türkiye. α-Pinene, β-pinene, 3-carene, limonene, 2-acetylfuran, benzaldehyde, acetic acid, benzoic acid, longifolene, isopentyl acetate, m-cymene, styrene, and δ-cadinene were the most common volatile components found in the most of propolis samples. Principal component analysis (PCA) and hierarchical cluster analysis were performed on the gas chromatography-mass spectrometry (GC-MS) data to identify trends and clusters in the propolis samples.

Determination of free fatty acids and volatile compounds of butter oil produced from pasteurized and unpasteurized butter at different temperatures.

In this study, the effects of different raw materials, different processing temperatures, and storage temperatures on some properties of butter oil were investigated. Two different kinds of butter were produced from cream containing 40% milk fat. Both butter samples were processed into butter oil at three different temperatures (60, 90, and 120°C).