Anti-CCL22 increases regulatory T cells in CD4 T cells of rheumatoid arthritis patients via STAT5 pathway.

Abnormality in the number and function of CD4CD25FOXP3 regulatory T cells (Tregs) in peripheral blood has been linked to the initiation and progression of rheumatoid arthritis (RA). Effect of chemokine CCL22 on the number of Tregs in CD4 T cells and the underlying mechanism were investigated. Downregulation of peripheral Tregs were observed while upregulation of serum chemokine CCL22 in RA patients.

CtBP1 overexpression in keratinocytes perturbs skin homeostasis.

Carboxyl-terminal-binding protein-1 (CtBP1) is a transcriptional corepressor with multiple in vitro targets, but its in vivo functions are largely unknown. We generated keratinocyte-specific CtBP1 transgenic mice with a keratin-5 promoter (K5.CtBP1) to probe the pathological roles of CtBP1.

[Observation on therapeutic effects of elongated needle therapy on dysuria induced by benign prostatic hyperplasia].

Objective: To compare therapeutic effects of elongated needle therapy and routine acupuncture therapy on dysuria induced by benign prostatic hyperplasia (BPH).

Methods: Randomized, controlled, multi-central method was adopted and 150 cases confirmed to the enrolled criteria were divided into two groups by odd or even number, an elongated needle group (n = 72) and a routine acupuncture group (n = 78). Acupuncture was given at bilateral Zhibian (BL 54) and Zhongji (CV 3) in the two groups, once daily, 5 sessions constituting one course, with a 2-day interval between two courses.

[Effect of shengji huayu recipe and its disassembled formulae on type I and III collagen synthesis in wound healing fibroblasts].

Objective: To explore the mechanism of Shengji Huayu Recipe (SJHYR) and its 3 disassembled formulae in accelerating wound healing toward skin restoration.

Methods: Using in vitro cultured fibroblasts from granulation tissue of wound and compared with the normal skin fibroblast of suckling rat, who were treated separately by drug serum containing high and low dose SJHYR and its disassembled prescriptions (Shengji formula and Huayu formula). The type I and III collagen contents in the fibroblasts were determined with immunocytochemical ABC method.

[Clinical and experimental study on improving cellular immunological function of uterine myoma patients by xiaoliu tablet].

Objective: To explore the effect of Xiaoliu Tablet (XLT) in treating uterine myoma (UM) and the relationship between effect and the cellular immunological function of the UM patients.

Methods: Seventy-one UM patients by treatment with XLT was observed. The activities of natural killer (NK) cells of 50 patients and 30 normal women were determined.