2 results match your criteria: "Yuebei People Hospital Affiliated to Medical College of Shantou University[Affiliation]"
Therapeutic effects of paeonol on non‑small cell lung cancer cells via regulation of the MAPK pathway.
Oncol Lett
December 2024
Department of Thoracic Surgery, Yuebei People Hospital Affiliated to Medical College of Shantou University, Shaoguan, Guangdong 512000, P.R. China.
Article Synopsis
- The study explored how paeonol affects DNA repair, triggers cell death (apoptosis), and reduces cell survival in non-small cell lung cancer cells (H1299) using the MAPK pathway.
- Human bronchial epithelial cells (BEAS-2B) and H1299 cells were treated with varying concentrations of paeonol, and different assays were conducted to assess cell viability, apoptosis, and DNA damage.
- Results showed that higher doses of paeonol decreased cell viability and colony formation while increasing apoptosis and DNA damage, affecting key proteins involved in cell survival and the MAPK signaling pathway.
Circular RNA hsa_circ_0075542 acts as a sponge for microRNA-1197 to suppress malignant characteristics and promote apoptosis in prostate cancer cells.
Bioengineered
December 2021
Department of Urology, Yuebei People Hospital Affiliated to Medical College of Shantou University, Shaoguan, China.
Numerous differentially expressed circular RNAs (circRNAs) have been identified; however, their roles have not been fully elucidated. Since dysregulated circRNAs may have clinical applications, it is vital to study their expression characteristics, function, and mechanism in prostate cancer cells. The role, regulatory mechanism, and expression of hsa_circ_0075542 were analyzed using quantitative reverse transcription polymerase chain reaction.
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