The Impact of Body Mass Index and Benign Prostatic Hyperplasia on Bone Health of Middle-Aged and Older Men.

Objective: Osteoporosis significantly affects older adults by reducing bone mass and increasing fracture risk, thereby impacting morbidity and mortality. This study aimed to investigate the relationship between bone mineral density (BMD), body mass index (BMI), and trabecular bone score (TBS) among middle-aged and older men with or without benign prostatic hyperplasia (BPH).

Methods: A retrospective study was conducted using health examination data from male participants aged 50-98 years collected at a regional hospital in southern Taiwan.

The association between grade of coronary heart disease and risk of developing keratopathy: a nationwide cohort study.

To evaluate the association between coronary heart disease (CHD) severity and the risk of developing keratopathy. A retrospective cohort study was conducted with data from the Taiwan National Health Insurance Research Database (NHIRD). A total of 593100, 593100 and 296500 patients were included in the control, mild CHD and severe CHD groups, respectively.

Functionalities of Polysaccharides Modified with Gallic Acid.

This research aimed to modify polysaccharides extracted from the edible mushroom with gallic acid (GA) and to complex them with zinc ions. The functionalities of the modified polysaccharides (TFPs) were investigated. Regarding antioxidant activity, TFP-GA demonstrated effective scavenging activity against DPPH radicals, nitric oxide, and hydrogen peroxide.

A Comparative Analysis of Toxicology and Non-Toxicology Care in Intoxicated Patients with Acute Kidney Injury.

: Intoxicated patients with acute kidney injury (AKI) experience high morbidity and mortality. While prior studies suggest that toxicology care settings improve outcomes, the impact of care settings on patients with AKI remains unclear. This study aimed to compare the outcomes of intoxicated patients with AKI managed in toxicology versus non-toxicology care settings.

Fenofibrate Inhibits LPS and Zymosan-induced Inflammatory Responses through Sonic Hedgehog in IMG Cells.

Background: Neuroinflammatory responses are strongly associated with the pathogenesis of progressive neurodegenerative conditions and mood disorders. Modulating microglial activation is a potential strategy for developing protective treatments for central nervous system (CNS)-related diseases. Fibrates, widely used in clinical practice as cholesterol-lowering medications, exhibit numerous biological activities, such as anticancer and antiinflammatory activities.

Preparation and Rheological Evaluation of Thiol-Maleimide/Thiol-Thiol Double Self-Crosslinking Hyaluronic Acid-Based Hydrogels as Dermal Fillers for Aesthetic Medicine.

This study presents the development of thiol-maleimide/thiol-thiol double self-crosslinking hyaluronic acid-based (HA) hydrogels for use as dermal fillers. Hyaluronic acid with varying degrees of maleimide substitution (10%, 20%, and 30%) was synthesized and characterized, and HA hydrogels were fabricated using two molecular weights of four-arm polyethylene glycol (PEG10K/20K)-thiol as crosslinkers. The six resulting HA hydrogels demonstrated solid-like behavior with distinct physical and rheological properties.

Voxel-based evaluation for [F] Florbetaben brain β-amyloid positron emission tomography of healthy control, mild cognitive impairment, and Alzheimer's disease.

Background: Positron emission tomography (PET) scans are commonly used to diagnose Alzheimer's disease (AD) by detecting β-amyloid (Aβ) deposition in the cortex; however, brain amyloid plaque load (BAPL) scores based on the visual interpretation of experts are highly subjective. In the current retrospective study, voxel-based processing of [F] Florbetaben ([F] FBB) Aβ PET scans was used to compare images from patients with AD, patients with mild cognitive impairment (MCI), and healthy controls (HCs). The aim of our study was to highlight the gray matter voxels that were higher uptake than white matter and perform group comparison of the numbers of these voxels among AD, MCI and HC subjects.

Effectiveness Study of a Cultural Adaptation of Cognitive-Behavioural Therapy-Based Application for Depressive Symptoms in College Students: A Randomised Controlled Trial.

Introduction: Studies on mental health applications among college students lack empirical evidence regarding mobile application usage's intensity, duration and frequency.

Aim: To evaluate the effectiveness of a cognitive-behavioural therapy (CBT)-based mobile application in ameliorating depressive symptoms among college students.

Methods: A randomised controlled trial was conducted at three universities.

The refractive accuracy between topographic keratometry and biometric keratometry for extended depth-of-focus intraocular lens implantation.

To investigate the influence of different keratometry (K) measurements on the postoperative outcomes of cataract surgery with extended depth-of-focus (EDOF) intraocular lens (IOL) implantation. A retrospective cohort study was conducted, and patients who received cataract surgery and one type of EDOF IOL implantation were included. The patients were then categorized according to K measurements, and 70 and 30 eyes were included in the biometric-K and topographic-K groups, respectively.

Zingerone Facilitates Apoptosis in Triple Negative Breast Cancer Cells by Inducing Autophagy.

Triple negative breast cancer (TNBC) is characterized by high heterogenicity and aggressiveness and autophagy plays a complicated role in cancer development. Zingerone is reported to possess multiple pharmacological activities, including antitumors. This study explored the biological role and the relevant mechanisms of zingerone in TNBC.

Semaglutide Ameliorates Diabetic Neuropathic Pain by Inhibiting Neuroinflammation in the Spinal Cord.

Unlabelled: Glucagon-like peptide 1 (GLP-1) receptor agonists are frequently used to treat type 2 diabetes and obesity. Despite the development of several drugs for neuropathic pain management, their poor efficacy, tolerance, addiction potential, and side effects limit their usage. Teneligliptin, a DPP-4 inhibitor, has been shown to reduce spinal astrocyte activation and neuropathic pain caused by partial sciatic nerve transection.

Effectiveness of resistance training in preventing sarcopenia among breast cancer patients undergoing chemotherapy: A systematic review and meta-analysis.

Background: Breast cancer patients undergoing chemotherapy experience body composition changes impacting treatment outcomes. The role of resistance training in mitigating chemotherapy-induced sarcopenia in breast cancer patients is not well defined.

Aims: This study aims to assess the efficacy of resistance training in preventing sarcopenia among breast cancer patients undergoing chemotherapy.

Effects of statins in patients with coronary artery spasm: A nationwide population-based study.

Controversies regarding the benefits of statin treatment on clinical outcomes in coronary artery spasm (CAS) without obstructive coronary artery disease (CAD) persist due to limited data. In this retrospective nationwide population-based cohort study from the Taiwan National Health Insurance Research Database during the period 2000-2012, the matched cohorts consisted of 12,000 patients with CAS. After propensity score matching with 1:1 ratio, 2216 patients were eligible for outcome analysis in either statin or nonstatin group, with the mean follow-up duration of 4.

Effects of Auricular Acupressure on Postoperative Nausea and Vomiting in Patients With Gynecological Laparoscopic Surgery: A Randomized Controlled Trial.

Purpose: Postoperative nausea and vomiting (PONV) is common among females undergoing gynecological surgeries. PONV not only causes patients discomfort but also leads to serious complications, affecting their health outcomes. This study aimed to evaluate the effectiveness of applying auricular acupressure to alleviate PONV and postoperative anxiety and to improve satisfaction with anesthesia care in patients undergoing gynecological laparoscopic surgery (GLS).

Anti-Inflammatory Effect of Medicinal Fungus Cultivated on Hayata.

Research Background: The fungus , which grows on tree, has many medicinal uses. However, its cultivation using the traditional method of growing on the tree is costly and time-consuming. A possible alternative method of cultivating is to use Hayata tree, as it contains α-terpineol, which stimulates the synthesis of triterpenoids.

Combined Treatment of Caffeic Acid Phenethyl Ester With Docetaxel Inhibits Survival of Non-small-cell Lung Cancer Cells Suppression of c-MYC.

Background/aim: Non-small-cell lung cancer (NSCLC) comprises approximately 85% of lung cancer. Treatment with docetaxel prolongs the survival of patients with NSCLC. However, the development of resistance to docetaxel has compromised its efficacy.

Association between Scabies Treatment and Parkinson's Disease: A Nationwide, Population-Based Study.

Background: Scabies is typically treated with scabicides like lindane, which poses a risk for acute neural toxicity. Lindane's prolonged use, particularly in agriculture, is linked to neurodegenerative diseases, including Parkinson's disease (PD), the second most common neurodegenerative disorder. This study aimed to evaluate whether scabies patients, particularly those treated with topical lindane, are at increased risk of developing PD.

Enhancing Europium Adsorption Effect of Fe on Several Geological Materials by Applying XANES, EXAFS, and Wavelet Transform Techniques.

This study conducted adsorption experiments using Europium (Eu(III)) on geological materials collected from Taiwan. Batch tests on argillite, basalt, granite, and biotite showed that argillite and basalt exhibited strong adsorption reactions with Eu. X-ray diffraction (XRD) analysis also clearly indicated differences before and after adsorption.

Red stripe on left forearm after stung by fish gill: A case report.

Rationale: Acute infectious lymphangitis represents a common complication of cellulitis, typically attributed to streptococcal infections after damaged skin integrity.

Patient Concern: This is a 51-year-old woman with a medical history of relapsing polychondritis, managed with steroid and methotrexate therapy in the outpatient department. She presented with a progressive redness and swelling of the left hand, accompanied by purulent discharge, persisting for 5 days.

Development and validation of deep learning models for identifying the brand of pedicle screws on plain spine radiographs.

Background: In spinal revision surgery, previous pedicle screws (PS) may need to be replaced with new implants. Failure to accurately identify the brand of PS-based instrumentation preoperatively may increase the risk of perioperative complications. This study aimed to develop and validate an optimal deep learning (DL) model to identify the brand of PS-based instrumentation on plain radiographs of spine (PRS) using anteroposterior (AP) and lateral images.

Exploration of the flavor diversity of oolong teas: A comprehensive analysis using metabolomics, quantification techniques, and sensory evaluation.

The taste profile of oolong tea is intricately shaped by origins and roasting. Herein, a comprehensive approach integrating non-targeted metabolomics, quantitative analysis and sensory evaluations was employed to analyze the taste profile of oolong tea. 25 selected representative oolong teas, including Southern Fujian (MN), Northern Fujian (MB), and Taiwan (TW), were meticulously were classified into SX-RG-DD, GS, and TGY based on the chemical taste phenotypes.