Custom exome panel revealed new mutations in MAPK14 and novel mutation in RUNX2 gene in patients with PCOS.

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy and is both phenotypically and genotypically heterogeneous. A large number of genetic variants have been found in different genes, so far. Based on the literature, we identified 7 genes and aimed to find new causative variants in these genes.

Enhancing proteasome activity by NMDAR antagonists explains their therapeutic effect in neurodegenerative and mental diseases.

NMDAR antagonists, such as memantine and ketamine, have shown efficacy in treating neurodegenerative diseases and major depression. The mechanism by which these drugs correct the aforementioned diseases is still unknown. Our study reveals that these antagonists significantly enhance 20S proteasome activity, crucial for degrading intrinsically disordered, oxidatively damaged, or misfolded proteins, factors pivotal in neurodegenerative diseases like Alzheimer's and Parkinson's.

Incorporating the Malnutrition Screening Tool and the Malnutrition Universal Screening Tool in Rehabilitation Practice: Comparison With the Nutrition Risk Screening 2002.

To demonstrate the prevalence of malnutrition risk in a specific rehabilitation setting. The secondary aim of the study was to compare Malnutrition Screening Tool (MST) and Malnutrition Universal Screening Tool (MUST) with Nutritional Risk Screening-2002 (NRS-2002). Patients diagnosed with stroke, anoxic brain injury, spinal cord injury, multiple sclerosis, arthritis, neuromuscular diseases, Parkinson's disease, and lymphedema who were admitted to a rehabilitation hospital were included.

Relationships Among Growth, Carcass Characteristics, and , and Genes Expression Level in Saanen Male Kids with Varying Slaughter Weights.

The objective of this study was to determine the relationship between the MRF gene family members and slaughter characteristics in Saanen kids with varying slaughter weights. Twenty male kids of the Turkish Saanen breed were individually fattened for 60 days after weaning under an intensive management system. The kids were divided into two groups: low slaughter weight (L; = 11; ≤29 kg) and high slaughter weight (H; = 13; >29) at the end of the fattening.

Complete Genome Characterization of Canine Adenovirus From Türkiye With Next-Generation Sequencing.

Background: Determining the complete genome sequence data of adenoviruses has recently become greatly important due to their use by scientists as vectors in cancer studies and other fields, including vaccine development. However, the GenBank database currently has few complete genome sequences of adenoviruses, which are known for their large genomes. To address this gap, we analysed next-generation sequencing data obtained from our previous study to provide the complete genome sequence of the canine adenovirus-2 strain.

The Effect of Maropitant, Ondansetron and Metoclopramide on Dexmedetomidine-Induced Vomiting in Cats.

Objectives: Vomiting is frequently observed in cats after dexmedetomidine administration. This study aimed to compare the efficacy of different antiemetics in preventing vomiting in cats after dexmedetomidine administration.

Methods: Sixty-four cats were randomly allocated to receive saline solution (0.

Investigation of the In Vitro Antioxidant, Anticholinesterase, Antiurease, Antityrosinase, and Cytotoxic Properties of a Novel Compound: 4-Methoxy-2-(4-Methoxyphenyl)Benzo[d][1,3,2]Dioxaborole.

In this study, the structure of a new boron compound obtained using 3-methoxy catechol and 4-methoxy phenyl boronic acid was characterized by H, C NMR, LC-MS-IT-TOF, UV-Vis and FTIR spectroscopy. The antioxidant activities of the newly synthesized compound were evaluated by DPPH free radical scavenging, ABTS quation radical scavenging and CUPRAC copper reducing capacity methods. Anticholinesterase activities were determined by acetylcholinesterase and butyrylcholinesterase enzyme inhibitor assays.

Morphological Features of the Pecten Oculi in the Common Kestrel (Falco tinnunculus).

This study aimed to investigate the macroscopic, light microscopic (LM) and scanning electron microscopic (SEM) characteristics of the pecten oculi in common kestrels (Falco tinnunculus). A total of six eyeballs from three common kestrels were used as the study material. The examination revealed that the bulbus oculi was spherical in shape and its diameter exceeded the axial-global length.

Effect of hand massage after abdominal surgery on pain, emotional symptoms and physiological parameters among children.

Aim: This randomized controlled study aimed to evaluate the effect of hand massage on pain, emotional symptoms, and physiological parameters in children after abdominal surgery.

Materials And Methods: The study included 40 children aged 7-12 years who underwent abdominal surgery (20 intervention, 20 control). Data were collected using the Faces Pain Scale-Revised, Children's Emotion Manifestation Scale, Physiological Measurements Chart, and Child Information Form.

Determination of streptococcus mutans retention in acidic and neutral pH artificial saliva environment of all-ceramic materials with different surface treatment.

Background: Although surface finishing processes are effective against Streptococcus mutans biofilm, the mechanism of action of saliva with different acidity values ​​has not been studied in detail. This study aims to produce four different all-ceramic materials in a single session with CAD/CAM devices and apply two different surface finishing processes, glazing and polishing, and then determine the retention of Streptococcus mutants on the surfaces of the materials in saliva with varying levels of acidity.

Methods: Zirconia-reinforced lithium silicate (Vita Suprinity, Vita Zahnfabrik, Bad Saöckingen, Germany), monochromatic feldspar (Vitablocs Mark 2, Vita Zahnfabrik, Bad Saöckingen, Germany), leucite glass ceramic (IPS Empress CAD, Ivoclar Vivadent, Liechtenstein), and monolithic zirconia (Incoris TZI (Cerec) Sirona, Germany) were used in the study.

Does smartphone addiction impact happiness? exploring the mediating roles of belongingness and fear of missing out: a cross-sectional survey from Turkey.

The aim of the study is to determine whether the fear of missing out (FoMO) has a mediating role in the effect of general belongingness (acceptance, exclusion) and happiness on smartphone addiction. The study consists of 656 university students from Turkey and agreeing to participate in the study. Of the students participating in the study, 77.

Candida species covered from traditional cheeses: Characterization of C. albicans regarding virulence factors, biofilm formation, caseinase activity, antifungal resistance and phylogeny.

This study has provided characterization data (carriage of virulence, antifungal resistance, caseinase activity, biofilm-forming ability and genotyping) of Candida albicans isolates and the occurrence of Candida species in traditional cheeses collected from Kayseri, Türkiye. Phenotypic (E-test, Congo red agar and microtiter plate tests) and molecular tests (identification, virulence factors, biofilm-formation, antifungal susceptibility) were carried out. The phylogenetic relatedness of C.

The role of habitat preference and feeding strategy on exposure to microplastic pollution in freshwater fish species.

Microplastic (MP) pollution has been observed in a variety of ecosystems, but there is a limited number of studies on reservoir ecosystems. The aim of this study was to determine the levels of MP contamination in sediment, water and commercially important fish species (Cyprinus carpio, Perca fluviatilis, Atherina boyeri and Sander lucioperca) collected from the Yamula Reservoir in Türkiye. Water samples were collectes at five stations.

Comparison of human smartwatch and transmittance pulse oximetry for evaluating peripheral oxygen saturation in anesthetized dogs.

Background: Pulse oximetry is a valuable tool for monitoring animals during anesthesia and assessing the adequacy of administered oxygen therapy.

Aims: To compare the pulse oximeter readings obtained by the Garmin Fenix 5X plus (GF5Xp) smartwatch and transmittance pulse oximetry (TPO) in anesthetized dogs.

Methods: Twelve clinical canine patients requiring anesthesia for castration were prospectively enrolled in this study.

Optimizing Grape Quality Through Tillage and Organic Fertilization: A Comprehensive Analysis of Phenolic and Anthocyanin Variability Over Three Years.

Knowing the concentration levels of phenolic compounds and anthocyanins in grape berries plays a key role, as these compounds significantly contribute to the nutritional value and quality of grapes, affecting both health benefits and grape quality. The current study was conducted to investigate how different tillage (disc harrow, chisel, no tillage) and organic fertilizer (Antep radish and broccoli chopped residue, olive blackwater) treatments affect the concentration of these valuable compounds in Royal grape berries over three consecutive years (2020-2022), providing insights into optimal agricultural practices for enhancing grape quality. Our results documented significant variations in phenolic and anthocyanin concentrations across different soil tillage, organic fertilizer treatments and years.

Evaluation of the effect of tartrazine on the offspring rats in an in vivo experimental model.

Tartrazine, an azo dye prevalent in pharmaceuticals and food items, was investigated for its impact on fetal development, specifically examining visceral and skeletal abnormalities in rat offspring exposed to daily oral doses throughout pregnancy. Fourteen pregnant rats were randomly assigned to control and tartrazine groups (seven animals each), with tartrazine administered via oral gavage at 7.5 mg/kg throughout gestation.

Young people's attitudes toward marriage, gender roles, and related factors : Attitudes toward marriage, gender roles.

Background: In this study, the effects of university students' sociodemographic characteristics and their thoughts on marriage on their attitudes towards marriage and gender roles were discussed.

Methods: A cross-sectional descriptive study was designed, involving a sample of 1082 university students. The data for this study were collected using a socio-demographic questionnaire, the Inönü Marital Attitude Scale (IMAS), and the Gender Roles Attitude Scale (GRAS).

Altered cervical proprioception and biomechanics in obstructive sleep apnea: a case-control study.

Purpose: This study aimed to compare cervical proprioception and related biomechanical factors among patients with Obstructive Sleep Apnea (OSA) and asymptomatic controls.

Methods: In this case-control study, polysomnography scores (apnea-hypopnea index-AHI) were examined to determine the disease severity of the OSA group. Also, we evaluated cervical proprioception by using a laser pointer to detect joint repositioning error sense in cervical rotational movements.

The influence of digital literacy on mHealth app usability: The mediating role of patient expertise.

Objective: Mobile health (mHealth) applications are emerging as important healthcare technologies that can provide cost savings, better access to care, contribute to improved clinical outcomes, and support public health. An increasing number of mobile health (mHealth) applications are becoming available to download and use on mobile devices. However, unlocking this potential requires ensuring widespread acceptance and adoption of these applications.

Exploring the relationship between proactive personality, individual innovation, and mental health in university students.

Purpose: The aim of this study is to determine the effects of proactive personality and individual innovation characteristics of university students on their mental health together with their socio-demographic characteristics.

Methods: This cross-sectional study was conducted among students of Yozgat Bozok University in 2022. Data was collected using a sociodemographic information form, Individual Innovation Scale (IIS), Proactive Personality Scale (PPS), and the Depression-Anxiety-Stress Scale (DASS-21).

The Impact of Human-Animal Interaction on Animal Welfare and Owners' Job Performance: A Study on Cats, Dogs and Birds.

Human-Animal Interaction (HAI) has been significant since ancient times, initially with animals, especially dogs, assisting in hunting and food gathering. Over time, this relationship evolved into domestication, companionship, and therapeutic roles in society. In urban areas, pet ownership is widespread, driven by companionship, therapeutic benefits, and social status.