Nickel coating on plasmonic copper nanoparticles lowers cytotoxicity and enables colorimetric pH readout for antibacterial wound dressing application.

Wound infection poses a significant challenge to the natural healing process. It can impede various stages of wound healing, thereby hindering tissue regeneration and increasing the risk of systemic complications. Wound dressings emerged as a crucial option in the management of infections.

Ti and Zr complexes bearing guanidine-phenolate ligands: coordination chemistry and polymerization studies.

A series of group 4 bis(isopropoxide) complexes M[N^O](OPr), stabilized by guanidine-phenolate N^O ligands, have been prepared and used as catalysts for the polymerization of unpurified -lactide under solvent-free conditions at 130 °C. The resulting polylactic acid (PLA) presented heterotactic bias ( = 0.56-0.

Mild and catalytic electrocyclizations of heptatrienyl anions.

We report the synthesis of functionalized cycloheptanes by thermal electrocyclization of heptatrienyl anions under mild conditions. In addition, we disclose the first examples of this electrocyclization manifold conducted under catalytic conditions. Previously, electrocyclization of heptatrienyl systems required formation of anions with a strong base, resulting in limited functional group compatibility.

Viologen-based solution-processable ionic porous polymers for electrochromic applications.

Electrochromic porous thin films are promising for applications in smart windows and energy-efficient optical displays. However, their generally poor processing ability and excessive processing times remain grand challenges. Herein, we report the design and convenient synthesis of core-altered -arylated viologens with aldehyde groups (πV-CHO) as new building blocks to prepare soluble, viologen-embedded ionic porous polymers.

Pyridylic anions are soft nucleophiles in the palladium-catalyzed C(sp)-H allylation of 4-alkylpyridines.

We report a mild palladium-catalyzed method for the selective allylation of 4-alkylpyridines in which highly basic pyridylic anions behave as soft nucleophiles. This method exploits alkylidene dihydropyridines, which are semi-stable intermediates readily formed using a 'soft-enolization' approach, in a new mechanistic manifold for decarboxylative allylation. Notably, the catalytic generation of pyridylic anions results in a substantially broader functional group tolerance compared to other pyridine allylation methods.

Single-nucleotide resolution of -adenine methylation sites in DNA and RNA by nitrite sequencing.

A single-nucleotide resolution sequencing method of -adenine methylation sites in DNA and RNA is described. Using sodium nitrite under acidic conditions, chemoselective deamination of unmethylated adenines readily occurs, without competing deamination of -adenine sites. The deamination of adenines results in the formation of hypoxanthine bases, which are read by polymerases and reverse transcriptases as guanine; the methylated adenine sites resist deamination and are read as adenine.

Phosphoryl- and phosphonium-bridged viologens as stable two- and three-electron acceptors for organic electrodes.

Low molecular weight organic molecules that can accept multiple electrons at high reduction potentials are sought after as electrode materials for high-energy sustainable batteries. To date their synthesis has been difficult, and organic scaffolds for electron donors significantly outnumber electron acceptors. Herein, we report the synthesis and electronic properties of two highly electron-deficient phosphaviologen derivatives from a phosphorus-bridged 4,4'-bipyridine and characterize their electrochemical properties.

Cross-Coupling of Primary Amides to Aryl and Heteroaryl Partners Using (DiMeIHept)Pd Promoted by Trialkylboranes or B(CF).

Boron-derived Lewis acids have been shown to effectively promote the coupling of amide nucleophiles to a wide variety of oxidative addition partners using Pd-NHC catalysts. Through a combination of NMR spectroscopy and control studies with and without oxygen and radical scavengers, we propose that boron-imidates form under the basic reaction conditions that aid coordination of nitrogen to Pd(II), which is rate limiting, and directly delivers the intermediate for reductive elimination.

Affective Change in Psychodynamic Psychotherapy: Theoretical Models and Clinical Approaches to Changing Emotions.

Objectives: Affective change has been considered the hallmark of therapeutic change in psychoanalysis. Psychoanalytic writers have begun to incorporate theoretically the advanced understanding of emotional processing and transformation of the affective neurosciences. We ask if this theoretical advancement is reflected in treatment techniques addressing the processing of emotion.

Synthesis of α,β-Unsaturated Acylsilanes via Perrhenate-Catalyzed Meyer-Schuster Rearrangement of 1-Silylalkyn-3-ols.

We report the synthesis of α,β-unsaturated acylsilanes via the perrhenate-catalyzed Meyer-Schuster rearrangement of 1-silylalkyn-3-ols. Propargylic alcohols derived from TES-acetylene and substituted benzaldehydes can be converted to acylsilanes using a combination of p-TSA·H(2)O and n-Bu(4)N·ReO(4), or Ph(3)SiOReO(3) in good yields. Some propargylic alcohols derived from ketones, as well as aliphatic and unsaturated aldehydes, can also be converted to acylsilanes; however, they were often prone to side reactions.

Palladium-catalyzed cross-coupling of benzyl chlorides with cyclopropanol-derived ketone homoenolates.

The palladium-catalyzed cross-coupling reaction of cyclopropanol-derived ketone homoenolates with benzyl chlorides is reported. This reaction proceeds in high yields with electron-neutral and electron-rich benzyl chlorides; however, yields are low with electron-poor benzyl chlorides. In addition, a range of cyclopropanols can be coupled in good yields.

Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd-PEPPSI-IPent.

Pd-PEPPSI-IPent has proven to be an excellent catalyst for the Negishi cross-coupling reaction of secondary alkylzinc reagents with a wide variety of aryl/heteroaryl halides. Importantly, β-hydride elimination/migratory insertion of the organometallic leading to the production of isomeric coupling products has been significantly reduced using the highly-hindered Ipent ligand.

Construction of null statistics in permutation-based multiple testing for multi-factorial microarray experiments.

Motivation: The parametric F-test has been widely used in the analysis of factorial microarray experiments to assess treatment effects. However, the normality assumption is often untenable for microarray experiments with small replications. Therefore, permutation-based methods are called for help to assess the statistical significance.

Work experiences and psychological well-being of former hospital-based nurses now employed elsewhere.

Hospitals in Ontario have undergone significant restructuring and downsizing during the past few years. Such changes have created negative reactions among both those who survive the downsizing and those who lose their jobs involuntarily. This study compared work satisfactions and indicators of psychological well-being of 36 nurses during these changes and three years later when they were employed elsewhere.