1,785 results match your criteria: "Yonsei University College of Dentistry.[Affiliation]"

Article Synopsis
  • High-dose denosumab (Xgeva®) is used for treating bone metastasis but has a risk of medication-related osteonecrosis of the jaw (MRONJ), which this study aimed to evaluate in terms of incidence, risk factors, and outcomes.
  • The study analyzed data from 1278 patients who received high-dose denosumab, finding that 34 (2.66%) developed MRONJ, with higher risk associated with older age and more frequent injections.
  • The findings emphasize the need for careful monitoring and education for older patients or those undergoing long-term treatment to reduce MRONJ risk.
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Aim: Despite the high success rate of endodontic microsurgery (EMS), it is difficult to suggest EMS as a general treatment option considering the difficulty of the procedure. A surgical guide has been proposed to overcome this problem. This study aimed to evaluate the stability of the surgical guide of a new design concept, as well as the accuracy of root resection, and to introduce the manufacturing method of the newly designed surgical guide.

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Development and validation of polymer-based porphyrin-incorporated reference materials for calibration of quantitative light-induced fluorescence device.

Photodiagnosis Photodyn Ther

December 2024

Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul, Republic of Korea; BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Republic of Korea. Electronic address:

Article Synopsis
  • The study focused on creating and validating polymer materials with varying porphyrin levels to improve the accuracy of quantitative light-induced fluorescence (QLF) devices.
  • Reference materials were analyzed for surface properties and fluorescence, revealing that porphyrin content did not affect surface characteristics, but significantly influenced color and fluorescence readings based on background conditions.
  • The findings suggest these new polymer-based materials can serve as reliable reference standards for calibrating QLF devices, emphasizing the role of background conditions in fluorescence detection.
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Anti-cariogenic effect of experimental resin cement containing ursolic acid using dental microcosm biofilm.

J Dent

December 2024

Department of Conservative Dentistry, Gangnam Severance hospital, College of Dentistry, Yonsei University, Seoul, Republic of Korea. Electronic address:

Objective: This study aimed to assess the anticariogenic effects of resin cement containing varying ursolic acid (UA) concentrations and to determine the optimal UA concentrations in the microcosm biofilm model.

Materials And Methods: Experimental resin cements with UA concentrations of 0, 0.1, 0.

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Fine particulate matter induces osteoclast-mediated bone loss in mice.

Korean J Physiol Pharmacol

January 2025

Department of Dental Hygiene, College of Software and Digital Healthcare Convergence, Yonsei University, Wonju 26493, Korea.

Fine particulate matter (FPM) is a major component of air pollution and has emerged as a significant global health concern owing to its adverse health effects. Previous studies have investigated the correlation between bone health and FPM through cohort or review studies. However, the effects of FPM exposure on bone health are poorly understood.

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Laryngospasm following orthognathic surgery: an unusual case report.

J Korean Assoc Oral Maxillofac Surg

October 2024

Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul, Korea.

This study discusses laryngospasm following orthognathic surgery and requiring emergency intubation, followed by systemic complications due to a hypoxic event. A 34-year-old male patient underwent orthognathic surgery due to facial asymmetry. When emerging from general anesthesia, blood pressure elevated suddenly, and severe agitation occurred.

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Style harmonization of panoramic radiography using deep learning.

Oral Radiol

January 2025

Department of Oral and Maxillofacial Radiology, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, Republic of Korea.

Article Synopsis
  • * A total of 15,624 images were analyzed, and a specific subset of 222 image pairs was used to evaluate how well the P-unit images could be transformed to resemble those from the R-unit.
  • * Results showed that the harmonized images had better similarity metrics compared to original P-unit images, with experts identifying a significant portion of them as resembling R-unit images, indicating the effectiveness of CycleGAN for this purpose.
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Anatomical consideration and techniques in thread nose augmentation with mesh scaffold implant.

J Dermatolog Treat

December 2024

Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seodaemun-gu, Seoul, Korea.

Introduction: Non-surgical rhinoplasty has evolved with the introduction of volumizing threads, which offer a less invasive alternative to traditional methods by enhancing nasal contours while minimizing filler use. This technique is gaining popularity, particularly in Southeast Asia, due to its shorter recovery time, reduced risk profile, and ability to prevent the 'Avatar nose' effect. However, there is limited anatomical guidance available for its application, especially in the Asian population.

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Decomposition and Changes in In Vivo Post-HA Filler Injection: A Review.

J Cosmet Dermatol

January 2025

Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.

Background: Hyaluronic acid (HA) fillers are widely used in aesthetic medicine, but their in vivo behavior and long-term effects are not fully understood.

Aims: To review the decomposition and changes occurring in the body following HA filler injections, focusing on crosslinking agents, degradation processes, and tissue responses.

Methods: This review analyzed oxidative and enzymatic degradation processes of HA fillers, evaluated the impact of 1,4-Butanediol Diglycidyl Ether (BDDE) crosslinking, and examined histological changes post-injection.

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Article Synopsis
  • - The study compared open versus closed healing methods after alveolar ridge preservation (ARP) in dogs with damaged extraction sockets, using specific materials for the procedure.
  • - Results showed that the open group had quicker wound healing and maintained more keratinized tissue compared to the closed group, although the overall ridge dimensions and new bone formation were similar between both methods.
  • - In conclusion, while both healing approaches produced comparable outcomes in ridge dimensions and bone growth, open healing minimized buccal bone loss and enhanced keratinized tissue.
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Efficacy of Subdermal Poly-d,l-Lactic Acid Injections for the Treatment of Melasma.

J Cosmet Dermatol

January 2025

Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.

Background: Melasma is a chronic, recurrent skin disorder with limited long-term treatment success using conventional therapies like hydroquinone and laser treatments, which primarily target epidermal components while leaving dermal aspects untreated.

Objective: To evaluate the efficacy and safety of poly-d,l lactic acid (PDLLA) subdermal injections for treating moderate melasma.

Methods: Three female patients (age range: 45-59 years) with Fitzpatrick skin types III and IV received three PDLLA injection sessions at 3-week intervals.

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Immunogenicity of Botulinum Toxin Type A in Different Clinical and Cosmetic Treatment, a Literature Review.

Life (Basel)

September 2024

Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50-1, Seoul 03722, Republic of Korea.

Article Synopsis
  • Botulinum toxin type A is widely used for therapeutic and aesthetic treatments, but there are concerns about its potential to generate antibodies, leading to treatment failure and adverse reactions.
  • This review evaluates the immunogenicity of different botulinum toxin type A products and identifies factors that increase the risk of antibody formation.
  • The findings indicate that while the overall incidence of neutralizing antibody formation is low, it can vary based on factors like injection frequency and total dose, necessitating further research to enhance treatment efficacy and minimize antibody-related issues.
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Viscoelastic and antimicrobial dental care bioplastic with recyclable life cycle.

Nat Commun

October 2024

Department of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University, Seoul, Republic of Korea.

Medical plastic-appliance-based healthcare services, especially in dentistry, generate tremendous amounts of plastic waste. Given the physiological features of our mouth, it is desirable to substitute dental care plastics with viscoelastic and antimicrobial bioplastics. Herein, we develop a medical-grade and sustainable bioplastic that is viscoelastic enough to align the tooth positions, resists microbial contamination, and exhibits recyclable life cycles.

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Retrobulbar Hyaluronidase Injection for Vascular Side Effects.

Aesthetic Plast Surg

October 2024

Division in Anatomy & Developmental Biology, Department of Oral Biology, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.

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Article Synopsis
  • The study examines the role of phase variation in the oipA gene of Helicobacter pylori, which is associated with IL-8 induction and gastric inflammation, in the context of H. pylori's overall virulence and potential links to gastric cancer.
  • Using two different strains, the research differentiates between natural and in vitro-induced phase variations of the oipA gene, discovering that while natural variations don’t significantly impact IL-8 induction or cell elongation, in vitro changes do show effects on cell morphology.
  • The findings highlight the complexity of genetic interactions influencing the virulence of H. pylori, suggesting that oipA phase variation plays a crucial, yet nuanced role in bacterial pathogenicity and warrants further investigation into
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Effects of icariin on dental pulp stem cells and its potential applications in dentin repair.

Arch Oral Biol

January 2025

Microscope Center, Department of Conservative Dentistry and Oral Science Research Center, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul 03722, South Korea. Electronic address:

Article Synopsis
  • The study investigates the effects of icariin, a biomolecule from Epimedium flowers, on promoting odontogenic differentiation in human dental pulp stem cells (hDPSCs) in vitro, and its potential as a pulp-capping agent in vivo.
  • Icariin, tested at concentrations of 10, 20, and 40 µM, showed no cytotoxic effects, enhanced cell migration, and increased markers for odontogenic differentiation in hDPSCs.
  • In an in vivo rat model, icariin effectively promoted reparative dentin formation, indicating its promising use in vital pulp therapy.
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Article Synopsis
  • The study focused on the career development experiences of Korean medical educators using the protean career theory, which emphasizes individual-led career growth.
  • Through semi-structured interviews with nine medical educators, the research utilized Interpretative Phenomenological Analysis to uncover their experiences in building careers amidst changing educational landscapes.
  • Findings indicated that these educators align with the protean career model, demonstrating traits like self-direction and adaptability, while also highlighting the importance of organizational support in their career journeys.
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Treatment with Hyaluronic Acid Filler into Calcaneal Fat Pad for Height Augmentation.

Aesthetic Plast Surg

October 2024

Medical Research In., Wonju, Wonju, Korea.

The heel fat pad plays a crucial role in shock absorption during walking, yet clinical strategies to augment its thickness for height enhancement remain underexplored. This case report presents the novel use of cross-linked hyaluronic acid (HA) injections into the calcaneal fat pad as a method for height augmentation. A 37-year-old male, with a height of 162.

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Orthognathic surgery in patients with lip and palate clefts is challenging owing to scar tissue from primary repairs and severe deformities. In this study, we evaluated the stability of Le Fort I osteotomy with intraoral vertical ramus osteotomy (IVRO) in patients with cleft lip and palate using 3-dimensional (3D) analysis. This retrospective study comprised 14 cleft lip and palate patients (3 females, 11 males; the average age at surgery: 23.

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This study investigated the mechanical properties of three denture base resin materials produced by three-dimensional (3D) printing (Group P), computer-aided design/computer-aided manufacturing milling (Group M), and conventional (Group C) methods. Three-point flexural tests were performed before and after thermocycling treatment to evaluate the mechanical properties. Additionally, nanoindentation and dynamic mechanical analysis (DMA) were used to analyze the behavior of the materials.

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Ocular and Periocular Tattoo Adverse Effects: A Review.

Diagnostics (Basel)

September 2024

Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.

Background: Ocular and periocular tattoos, involving ink application to the eyeball or surrounding skin, have gained popularity as forms of self-expression. However, this trend raises significant concerns about potential complications that can adversely affect ocular health and esthetics. Awareness of these risks is crucial for both patients and practitioners.

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Manufacturing Process of Hyaluronic Acid Dermal Fillers.

Polymers (Basel)

September 2024

BK21 FOUR Project, Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.

Hyaluronic acid (HA) fillers are extensively utilized in aesthetic medicine due to their biocompatibility, reversibility, and effectiveness in enhancing skin hydration, volume, and overall appearance. These fillers are predominantly produced through microbial fermentation, followed by a critical cross-linking process that enhances their longevity by resisting enzymatic degradation. This review provides a thorough examination of the manufacturing processes that differentiate HA fillers, with particular attention to the distinctions between biphasic and monophasic variants.

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Regenerative Endodontic Procedures With Minced Pulp Tissue Graft in Mature Permanent Teeth: A Clinical Study.

J Endod

January 2025

Microscope Center, Department of Conservative Dentistry and Oral Science Research Center, Yonsei University College of Dentistry, Seoul, Korea. Electronic address:

Article Synopsis
  • Regenerative endodontic procedures (REPs) using minced pulp tissue (MP) grafts aim to treat mature teeth and improve outcomes compared to traditional methods.
  • Healthy patients needing root canal treatment participated in a study where MP from their third molars was used to fill disinfected root canals, with follow-ups assessing clinical and radiographic results.
  • The study showed favorable outcomes in most cases, identifying influencing factors like apical foramen size and the composition of grafted tissue, suggesting that this approach may be a viable alternative to conventional treatments.
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Intramuscular neural distribution of the vastus medialis for botulinum neurotoxin injection: application to spasticity.

Surg Radiol Anat

December 2024

Department of Anatomy, School of Medicine, CHA University, 120, Haeryong-ro, Pocheon-si, Gyeonggi-do, 11160, Republic of Korea.

Purpose: A comprehensive understanding of neural distribution within the vastus medialis is crucial for the effective administration of botulinum neurotoxin injections to manage spasticity. The aim of this study was to develop an anatomically informed approach to guide the administration of botulinum neurotoxin injections into the vastus medialis muscle.

Methods: Using a modified Sihler's method, we examined the vastus medialis muscles (20 specimens) to delineate the distribution of nerves relative to a transverse line extending from the anterior superior iliac spine to the base of patella.

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Background: In very rare cases, patients who have undergone surgery-first approach with intraoral vertical ramus osteotomy (IVRO) exhibit unusual downward movements of mandible even up to 1-year post surgery, which makes it difficult for orthodontists to stabilize the occlusion during the postoperative orthodontic period. The aim of this study was to identify factors affecting the unusual downward movement of the mandible 1-year after the surgery-first approach using IVRO, while focusing on cephalometric values.

Methods: This retrospective cohort study sample was divided into two groups based on the amount of vertical movement of the B-point 1-year post surgery (Group S, predictable upward movement; Group U, unpredictable downward movement greater than 2 mm).

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