Real-Time Photocatalytic Measurement of Dental Materials in an Open System.

It is common to encounter discrepancies between in vitro and in vivo studies, particularly when assessing the antibiofilm efficacy of dental materials. Typically, dental materials are tested in a closed system where fresh nutrients are not replenished, the test conditions are static, and the same planktonic bacteria persist. However, real environments are characterized by the continuous supply of fresh nutrients, dynamic saliva flow, and the periodic removal of planktonic bacteria through swallowing.

Novel Approaches for Treatment of Intraoral Microbial Infections.

Historically, broad-spectrum antibiotics have represented a major component of the therapeutic armamentarium used to treat common oral diseases associated with a bacterial etiology. The fact that these diseases are due to the accumulation of multispecies biofilms composed of ever-increasing numbers of resistant organisms has dramatically affected the efficacy of many of these drugs. Furthermore, it is now appreciated that repeated use of broad-spectrum antibiotics also affects the composition of the host commensal microbiota, which can have both local and systemic implications.

Moldable and Particulate Bone Material in Alveolar Ridge Preservation: A Multicenter Randomized Controlled Trial.

Introduction: This study aimed to determine possible histological and radiological differences in alveolar ridge preservation (ARP), using moldable bone versus particulate bone.

Methods: After tooth extraction, 39 patients (40 teeth) were randomized (1:1) to receive ARP using moldable bone materials (SBX group) or particulate bone materials (PBX group). An absorbable collagen membrane was placed over the graft material and the surgical site was sutured.

Conditions to Consider When Choosing Fillers.

Background: The selection of dermal fillers in aesthetic medicine often relies on factors such as cost, immediate outcomes, and practitioner experience. However, incorporating knowledge of fillers' rheological properties, such as viscoelasticity and cohesiveness, allows for more precise product selection tailored to patient needs and treatment goals while reducing the risk of complications.

Aims: This review aims to summarize essential considerations for filler selection, focusing on rheological properties, safety profiles, and clinical applications.

Deformation analysis of 3D-printed three-unit fixed partial dentures according to various cleaning strategies after DLP 3D printing: a geometric library matching approach.

Purpose: Three-dimensional (3D) printing must go through a post-processing procedure. This study aimed to evaluate the effects of different cleaning methods on 3D printed three-unit fixed partial dentures using 3D analysis.

Materials And Methods: A three-unit fixed partial denture was designed and printed using two different printers.

Autonomic dysregulation as a potential regulator in otologic comorbidities of temporomandibular disorders.

Objectives: To explore the role of autonomic dysregulation in otologic symptoms among individuals with temporomandibular disorders (TMDs).

Methods: Data from 79,731 individuals were analyzed, categorized by the presence of TMD-related or otologic symptoms. Self-administered questionnaires screened TMD and otologic discomfort.

Efficient gingival health screening using biofluorescence of anterior dental biofilms.

Purpose: In study, we aimed to evaluate the biofluorescence of anterior dental biofilms using Quantitative Light-induced Fluorescence (QLF) technology to screen for gingival health.

Methods: Fifty-five (n=55) adult participants aged ≥ 20 years with gingivitis were included in this study. Fluorescence images of the upper and lower anterior teeth were obtained using Qraycam, a device based on the QLF technology.

Association of flap tension with flap design and graft volume in soft tissue augmentation: a cadaveric study in pigs.

Purpose: This study was performed to evaluate the effects of flap design, grafting material, and graft dimension on flap tension and the initial volume increase achieved in soft tissue augmentation.

Methods: Six fresh porcine jaw cadavers were used in this study. Each side of the jaw was randomly assigned to receive either a standard split-thickness flap or a split-thickness flap with a palatal island.

Standard operating procedures for quality control of oral biospecimens at the Korea Oral Biobank Network.

Purpose: The Korean Oral Biobank Network (KOBN) collects, stores, and provides oral samples for research. Quality control (QC) of biospecimens is necessary to ensure that they meet the basic prerequisites before being sent to researchers. This study presents the standard operating procedures (SOPs) for the QC of biospecimens.

Interpretable multimodal transformer for prediction of molecular subtypes and grades in adult-type diffuse gliomas.

Molecular subtyping and grading of adult-type diffuse gliomas are essential for treatment decisions and patient prognosis. We introduce GlioMT, an interpretable multimodal transformer that integrates imaging and clinical data to predict the molecular subtype and grade of adult-type diffuse gliomas according to the 2021 WHO classification. GlioMT is trained on multiparametric MRI data from an institutional set of 1053 patients with adult-type diffuse gliomas to predict the IDH mutation status, 1p/19q codeletion status, and tumor grade.

Cryo-EM structures of mouse bestrophin 1 channel in closed and partially open conformations.

Bestrophin-1 (BEST1) channels are calcium-activated Cl channels involved in diverse physiological processes, including gliotransmitter release in astrocytes. Although human and chicken BEST1 orthologs have been extensively studied, the structural and functional properties of mouse BEST1 (mBEST1) remain poorly understood. In this study, we characterized the structure-function of mBEST1-BF, a C-terminally tagged variant, using whole-cell patch-clamp recordings, surface biotinylation assays, and single-particle cryo-electron microscopy (cryo-EM).

Considerations for Proper Use of Hyaluronidase in the Management of Hyaluronic Acid Fillers.

Effective management of complications from hyaluronic acid (HA) fillers is crucial in aesthetic medicine. This article examined the role of hyaluronidase in addressing adverse effects associated with HA fillers, such as nodules, vascular occlusions, and excessive volume. It highlights the enzyme's ability to degrade HA, thereby resolving issues that may arise from filler treatments.

Effective Management of Thread Misplacement in Thread Lifting Procedures: A Clinical Case Utilizing the Hook for Extraction.

Thread lifting is a popular nonsurgical procedure for skin rejuvenation, utilizing bioabsorbable barbed threads inserted into subcutaneous or deeper structures such as the superficial musculoaponeurotic system. Despite its efficacy, complications such as thread misplacement can occur, leading to adverse outcomes such as dimpling, inflammation, and scar formation. This article presents a clinical case involving a 32-year-old woman with a superficially placed thread following a thread-lifting procedure.

Evidence-Based Anatomical Terminology in Dentistry Developed by a Consortium of Experts.

This article aimed to develop evidence-based anatomical terminology in dentistry agreed upon by experts in multiple fields and ultimately to bridge anatomy and clinical dentistry. A comprehensive list of dental anatomical terminology was detailed in table format, and specific terms of interest were highlighted with their respective literature review. The presence of teeth is a unique feature of the oral cavity where dental professionals work.

Understanding Vascular Complications Arising From Dermal Filler Injection.

Soft tissue fillers are widely used in cosmetic procedures but carry inherent risks, especially vascular complications like tissue necrosis and vision loss due to retinal ischemia. Recent filler advancements beyond hyaluronic acid increase the risk of intravascular invasion during injections. Tissue necrosis follows distinct stages: initial blanching, skin mottling from tissue ischemia, discoloration, and possible necrosis.

Evaluating Poly-D,L-Lactic Acid for Lower Eyelid Rejuvenation: Efficacy and Safety.

Background: Injectable fillers like PDLLA offer a novel approach to addressing lower eyelid rejuvenation. Despite their growing popularity, comprehensive studies on newer products like PDLLA are limited.

Aims: This study evaluates the efficacy and safety of PDLLA (Juvelook, VAIM Inc.

Anatomy-Based Filler Injection: Treatment Techniques for Supraorbital Hollowness and Charming Roll.

Supraorbital hollowness and pretarsal fullness, commonly known as the sunken eyelid and charming roll, respectively, are significant anatomical features that impact the aesthetic appearance of the periorbital region. Supraorbital hollowness is characterized by a recessed appearance of the upper eyelid, often attributed to genetic factors, aging, or surgical alterations, such as excessive fat removal during blepharoplasty. This condition is particularly prevalent among East Asians due to anatomical differences, such as weaker levator muscles and unique fat distribution patterns.

An Expert Guide to Anatomy-Based Filler Injection for the Temple: Techniques and Clinical Insights.

Temporal hollowing is a common aesthetic concern addressed with filler injections using an anatomy-based approach. Understanding the complex anatomy of the temporal region, including the superficial temporal artery, temporal branch of the facial nerve, and sentinel vein, is essential for safe and effective treatment. Injection planes-subfascial, within the superficial temporal fat pad, or submuscular-are selected based on individual anatomy and desired outcomes.

Anatomical-Based Filler Injection Diagnosis to Treatment Techniques: Infraorbital Groove and Hollowness.

Infraorbital groove and hollowness are common aging-related anatomical changes in the periorbital region, leading to a sunken and tired appearance. These conditions are caused by the progressive loss of volume in the deep fat pads, including the sub-orbicularis oculi fat (SOOF) and malar fat, along with skin thinning and decreased elasticity. Filler injections, particularly hyaluronic acid-based fillers, are the preferred treatment to restore volume and smooth the under-eye area.

Needle Radiofrequency Combined with Topical Exosome Therapy for Moderate to Severe Acne.

Objective: This case series aims to evaluate the efficacy, patient satisfaction, and safety of combined needle radiofrequency (RF) and topical exosome therapy for moderate to severe acne.

Methods: This study involved 22 patients (12 females and 10 males, ages 18-35) with moderate to severe acne who underwent combined needle RF and topical exosome (Xomage, Zishel Bio Inc., Seoul, Republic of Korea) treatments.

Caries prevention effects of nano silver fluoride sustained release orthodontic elastomerics in dental microcosm biofilms.

Objectives: To evaluate the clinical applicability of nano silver fluoride sustained release orthodontic elastomerics (NSF-RE) by investigating its effects on inhibiting biofilm formation and enamel demineralization using dental microcosm biofilms.

Methods: Two types of 23 % NSF coating solutions were prepared depending on the presence or absence of the plasticizer (polyethylene glycol [PEG] 6000: NSF-EP and NSF-E); the elastomerics were dip-coated individually with these. Biofilms were allowed to form on bovine enamel specimens with the elastomerics.

Digenic impairments of haploinsufficient genes in patients with craniosynostosis.

Craniosynostosis (CRS) is characterized by the development of abnormal cranial suture ossification and premature fusion. Despite the identification of several associated genetic disorders, the genetic determinants of CRS remain poorly understood. In this study, we conducted integrative analyses on 225 exomes, comprising 121 CRS probands and 104 parental exomes (52 trios).

Deep learning image enhancement for confident diagnosis of TMJ osteoarthritis in zero-TE MR imaging.

Objective: This study aimed to evaluate the effectiveness of deep learning method for denoising and artifact reduction (AR) in zero-TE (ZTE) magnetic resonance imaging (MRI). Also, Clinical applicability was evaluated by comparing image diagnosis to the temporomandibular joint (TMJ) cone-beam computed tomography (CBCT).

Methods: For thirty patients CBCT and routine ZTE-MRI data was collected, and an additional reduced scan time-ZTE-MRI was also obtained.

Red biofluorescence revealed by dental bleaching in discolored pits and fissures of occlusal caries.

Objective: Distinguishing between cariogenic and noncariogenic discoloration is crucial to avoid unnecessary removal of dental tissue. This study aimed to investigate the efficacy of biofluorescence bleaching (BF-bleaching) for identifying cariogenic discoloration in human teeth with naturally discolored pits and fissures.

Methods: Sixty-nine extracted human permanent teeth with discolored pits and fissures associated with suspected occlusal caries were included.