574 results match your criteria: "Yongchuan Hospital of Chongqing Medical University[Affiliation]"

Background: The pathogenesis of acute kidney injury (AKI) is not fully understood. Tax1-binding protein 1 (TAX1BP1) modulates inflammation and apoptosis through the NF-kB signaling pathway, however, its specific role in ischemic AKI remains unclear.

Methods: We injected a TAX1BP1 overexpression plasmid into the tail vein of male C57BL/6 mice, followed by clamping the bilateral renal arteries to induce AKI.

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Electroconvulsive therapy (ECT) is recognized as one of the most efficacious interventions for depression. However, it is associated with impairments in learning and memory functions. Ketamine has demonstrated potential in mitigating cognitive deficits.

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Association between vestibular evoked myogenic potentials and different dizziness status in Parkinson's disease: A controlled study.

Clin Neurol Neurosurg

December 2024

Department of Neurology, Yongchuan Hospital of Chongqing Medical University, 439# Xuanhua Road, Yongchuan, Chongqing 402160, China; Chongqing Key Laboratory of Cerebrovascular Disease Research, 439# Xuanhua Road, Yongchuan, Chongqing 402160, China. Electronic address:

Objective: This study compared ocular and cervical vestibular evoked myogenic potentials (oVEMP and cVEMP) among individuals with Parkinson's disease (PD) without dizziness, with nonspecific dizziness (dizziness without orthostatic hypotension), or with dizziness combined with orthostatic hypotension.

Materials And Methods: We prospectively analyzed 30 of each of the three types of individuals who were admitted to Yongchuan Hospital of Chongqing Medical University (Chongqing, China) between June 2022 and April 2023. The three groups received oVEMP and cVEMP measurements using an electromyography-evoked potential system.

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Hippocampus carbonic anhydrase 1 via ERK pathway may be involved in depressive like behaviors.

J Affect Disord

December 2024

Chongqing Key Laboratory of Cerebrovascular Disease Research, Chongqing, 400016, China; Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, 400016, China; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address:

Major depressive disorder (MDD) is a destructive mental disease, yet the mechanism is still not clear. Carbonic anhydrase, an efficient catalyst for CO conversion to carbonate and protons, could affect many functions, such as memory formation recognition. Lately, we illustrated that carbonic anhydrase 1 (CAR1) knockout (CAR1) mice could lead to depressive-like behaviors, but the underlying molecular mechanism is unknown.

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Background: The albumin-bilirubin (ALBI) score has demonstrated prognostic value in a range for liver and heart diseases. However, its association with all-cause mortality in intensive care unit (ICU) patients with heart failure remains uncertain.

Objective: This study sought to investigate the relationship between the ALBI score and the risk of all-cause mortality in ICU patients with heart failure.

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Background: It is unclear whether the extent of neuroaxonal damage, as measured by circulating levels of neurofilament light chain (NfL), would modify the effects of early antihypertensive therapy on cognitive performance following stroke. This study aimed to investigate the effects of early blood pressure reduction on the risk of post-stroke cognitive impairment (PSCI) among patients with different plasma NfL levels.

Methods: A total of 622 eligible patients from a pre-planned ancillary study of CATIS (China Antihypertensive Trial in Acute Ischemic Stroke) were included in this study.

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Objectives: To evaluate the effectiveness of high-intensity focused ultrasound (HIFU) therapy for treating uterine fibroids by utilizing multi-sequence magnetic resonance imaging radiomic models.

Methods: One hundred and fifty patients in our hospital were randomly divided into a training cohort (n=120) and an internal test cohort (n=30), and forty-five patients from another hospital serving as an external test cohort. Radiomics features of uterine fibroids were extracted and selected based on preoperative T2-weighted imaging fat suppression(T2WI-FS)and contrast-enhanced T1WI(CE-T1WI)images, and logistic regression was used to develop the T2WI-FS, CE-T1WI, and combined T2WI-FS + CE-T1WI models, along with the radiomics-clinical model integrating radiomics features with imaging characteristics.

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Article Synopsis
  • A systematic review and meta-analysis was conducted to assess the effectiveness of mindfulness meditation (MM) for treating fibromyalgia syndrome (FMS), addressing a gap in existing research.
  • The review included 10 randomized controlled trials involving 818 patients and evaluated outcomes like pain impact, sleep quality, depression, and stress levels, using various mindfulness techniques.
  • Results suggested that MM may lead to short-term reductions in FMS symptoms, particularly in pain impact and depression, with varying levels of evidence ranging from very low to moderate.
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Does H3K27me3 expression play a role in patients with Blastic plasmacytoid dendritic cell neoplasm? A clinicopathologic analysis of 14 patients.

Ann Diagn Pathol

February 2025

Department of Pathology, Faculty of Basic Medicine, Chongqing Medical University, Chongqing, China; Molecular Medicine Diagnostic and Testing Center, Chongqing Medical University, Chongqing, China; Department of Pathology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive lymphohematopoietic malignancy associated with poor prognosis. We aimed to improve the understanding of BPDCN, explore its prognostic significance, and identify potential therapeutic targets. Data from 14 BPDCN patients were retrospectively collected and analyzed, focusing on their clinicopathological characteristics, diagnostic features, immunophenotype, treatment regimens, and prognostic factors.

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Article Synopsis
  • - The study focused on identifying risk factors for COVID-19 pneumonia specifically in patients with hematological malignancies (HM) during the Omicron BA.5.2 wave in Chongqing, China.
  • - Among 475 enrolled HM patients, 15.8% developed COVID-19 pneumonia, with significant risk factors including active disease status, incomplete COVID-19 vaccination, recent chemotherapy, and reduced NK-cell counts.
  • - The findings emphasize the need for serious clinical attention for HM patients with these risk factors to better manage potential lung complications following Omicron infection.
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  • * Researchers analyzed transcriptome and clinical data from The Cancer Genome Atlas, identifying 26 significant m7G-related genes, with METTL1 showing a strong correlation to ccRCC progression.
  • * The findings suggest that METTL1 could be a valuable biomarker for ccRCC prognosis and may influence treatment outcomes by affecting the tumor immune environment, offering new insights for potential immunotherapy approaches.
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BACKGROUND This study aimed to investigate the expression of RSPO3 and ß-catenin in preeclampsia and the relationship between RSPO3 and b-catenin levels and maternal-fetal outcomes. MATERIAL AND METHODS We enrolled 60 pregnant women with preeclampsia and 60 pregnant women without preeclampsia. We collected peripheral blood from the patients upon admission; placenta and cord blood were collected after delivery.

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BCL11A expression worsens the prognosis of DLBCL and its co-expression with C-MYC predicts poor survival.

Pathol Res Pract

December 2024

Department of Pathology, Faculty of Basic Medicine, Chongqing Medical University, Chongqing, China; Molecular Medicine Diagnostic and Testing Center, Chongqing Medical University, Chongqing, China; Department of Pathology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Non-Hodgkin's lymphoma (NHL) is a significant global malignancy, with diffuse large B cell lymphoma (DLBCL) being the most prevalent subtype, accounting for 25-50 % of newly diagnosed cases in China. Despite a 60 % survival rate achieved with R-CHOP regiment for DLBCL, approximately 40 % of patients experience relapse or develop resistance to treatment. While the oncogenic transcription factor B-cell chronic lymphocytic leukaemia/lymphoma 11 A (BCL11A) has been implicated in various tumors, its specific role in DLBCL remains unclear.

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Objective: This study aimed to investigate risk factors associated with severe postoperative complications following hip fracture surgery in elderly patients and to develop a nomogram-based risk prediction model for these complications.

Methods: A total of 627 elderly patients with hip fractures treated at Yongchuan Hospital of Chongqing Medical University from January 2015 to April 2024 were collected. 439 patients were assigned to the training cohort for model development, and 188 to the validation cohort for model assessment.

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Objective: Tirofiban plus recombinant tissue plasminogen activator (rtPA) shows good efficacy and safety in treating acute ischemic stroke (AIS) patients, but there is a lack of comprehensive assessment. This meta-analysis aimed to compare the efficacy and safety of rtPA plus tirofiban with rtPA alone in AIS patients.

Methods: This meta-analysis retrieved studies comparing rtPA intravenous thrombolysis followed by tirofiban (rtPA+T group) versus rtPA intravenous thrombolysis alone (rtPA group) for AIS patients in Excerpt Medica Database, Web of Science, Cochrane, PubMed, China National Knowledge Infrastructure, Wanfang, and SinoMed until March 2024.

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Article Synopsis
  • The study aimed to explore the effects of low doses of esketamine on postpartum depression and pain in women after elective cesarean sections.
  • It involved 150 participants who were given either esketamine or a placebo, and outcomes measured included the incidence of postpartum depression and postoperative pain.
  • Results showed no difference in postpartum depression rates between the two groups, but those receiving esketamine reported lower pain levels at 24 hours post-surgery and experienced some temporary side effects shortly after administration.
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Comparative transcriptional analyses of the striatum in the chronic social defeat stress model in C57BL/6J male mice and the gut microbiota-dysbiosis model in Kumming mice.

Neuroscience

December 2024

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; The Jin Feng Laboratory, Chongqing 401329, China. Electronic address:

Depression is a complex disorder with multiple contributing factors, and chronic stress has previously been recognized as a major causative factor, while gut microbes have also been found to be involved in depression recently. However, gene expression in depression models with different etiologies is unclear. Here, we compared the transcriptomes of the striatum in chronic social defeat stress (CSDS) model of C57BL/6J male mice and fecal microbiota transplant (FMT) model of Kumming male mice.

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Article Synopsis
  • - Ischemic stroke leads to significant mortality and disability, with current treatments focusing on breaking up blood clots and protecting brain tissue from damage, but they face major challenges and limited options for neuroprotection.
  • - Researchers have developed a nanoplatform, MiCM@PLGA/anti-RGMa/FeO@PFH (MiCM-NPs), that uses a monoclonal antibody and microglia membranes to target damaged blood vessels, releasing therapeutic agents through ultrasound stimulation.
  • - This innovative approach not only helps dissolve blood clots using ultrasound but also protects brain tissue and allows for imaging of the affected area, showing promise in animal studies for safe and effective treatment of ischemic strokes.
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HTS and scRNA-seq revealed that the location and RSS quality of the mammalian TRBV and TRBJ genes impact biased rearrangement.

BMC Genomics

October 2024

Department of Immunology, Center of Immunomolecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China.

The quality of Recombination signal sequences (RSSs), location, and genetics of mammalian V, D, and J genes synergistically affect the recombination frequency of genes; however, the specific regulatory mechanism and efficiency have not been elucidated. By taking advantage of single-cell RNA-sequencing (scRNA-seq) and high-throughput sequencing (HTS) to investigate V(D)J rearrangement characteristics in the CDR3 repertoire, we found that the distal and proximal V genes (or J genes) "to D" gene were involved in rearrangement significantly more frequently than the middle V genes (or J genes) in the TRB locus among various species, including Primates (human and rhesus monkey), Rodentia (BALB/c, C57BL/6, and Kunming mice), Artiodactyla (buffalo), and Chiroptera (Rhinolophus affinis). The RSS quality of the V and J genes affected their frequency in rearrangement to varying degrees, especially when the V-RSSs with recombination signal information content (RIC) score < -45 significantly reduced the recombination frequency of the V gene.

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Colorectal cancer (CRC) is one of the most common and deadly malignancies worldwide, and immune regulation plays a critical role in its development. This study investigates the causal relationships between uveitis, specific immune cell traits, and CRC using Mendelian Randomization (MR) analyses. A total of 21 single nucleotide polymorphisms (SNPs) associated with uveitis were identified, and the analysis revealed that a 1 log-odds increase in uveitis was linked to a statistically significant 3.

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Conventional methods for detecting single nucleotide polymorphisms (SNPs) in clinical practice often require substantial time, labor, and specialized equipment, limiting their widespread application. To address this limitation, we refined our previous SNP detection method, IMAS-RPA [introducing an extra mismatched base adjacent to the single-base mutant site by recombinase polymerase amplification (RPA)], resulting in an updated version termed IMAS-RPAv2. We began by introducing a suboptimal protospacer adjacent motif (PAM) sequence, GTTG, into the double-stranded DNA (dsDNA) products using either RPA or reverse transcription RPA.

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Background: The preoperative prediction of the pathological nuclear grade of clear cell renal cell carcinoma (CCRCC) is crucial for clinical decision making. However, radiomics features from one or two computed tomography (CT) phases are required to predict the CCRCC grade, which reduces the predictive performance and generalizability of this method. We aimed to develop and externally validate a multiparameter CT radiomics-based model for predicting the World Health Organization/International Society of Urological Pathology (WHO/ISUP) grade of CCRCC.

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Article Synopsis
  • Tafasitamab is an approved treatment for patients with relapsed/refractory diffuse large B-cell lymphoma who cannot undergo stem cell transplantation, and this study assessed its associated adverse events (AEs) using data from the FDA Adverse Event Reporting System (FAERS).
  • A disproportionality analysis identified 1,262 AEs from 529 reports related to tafasitamab, with the main concerns being cytopenia, immunosuppression, and other serious conditions like neutropenic sepsis and hematotoxicity.
  • The findings highlight the need for increased awareness among healthcare providers regarding the potential risks of tafasitamab, thus improving patient safety in clinical settings.
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  • - Our study investigates the long non-coding RNA, Pvt1, focusing on how its presence affects heart cell apoptosis and exploring the associated miRNA and mRNA interactions.
  • - We employed several methods, including gene knockdown using siRNA and adeno-associated virus, as well as various assays to measure cell apoptosis and cardiac function after inducing myocardial infarction in mice.
  • - Results showed that higher levels of Pvt1 in heart cells under low oxygen conditions lead to increased cell death, while reducing Pvt1 expression can enhance heart function and reduce damage after a heart attack in mice.
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