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Phyllodes tumors of breast (PTB) have been known to an uncommon and particular disease to handle owing to diagnostic ambiguity and unpredictable clinical outcome. Malignant phyllodes tumors (MPT) are diagnosed when there are marked stromal hypercellularity, atypia, increased mitoses of ≥10/10 HPFs, permeative tumor borders, and stromal overgrowth. The presence of a malignant heterologous element (MHE) places the tumor into the malignant category regardless of other histological features.
View Article and Find Full Text PDFIsoflavone intake on the risk of overall breast cancer and molecular subtypes in women at high risk for hereditary breast cancer.
Breast Cancer Res Treat
November 2020
Interdisciplinary Program in Cancer Biology, Seoul National University College of Medicine, Seoul, South Korea.
Article Synopsis
- The study explored the link between isoflavone (ISF) intake and the risk of hereditary breast cancer (BC) among East-Asian women, focusing on BRCA1/2 mutation carriers and other high-risk groups.
- The research involved 1,709 participants and utilized hazard ratios and confidence intervals to assess the relationship between ISF consumption and different breast cancer subtypes.
- Findings indicated that higher ISF intake is associated with a lower risk of luminal A and triple negative breast cancer among BRCA mutation carriers and women with a family history of breast cancer.