Venous leg symptoms, ecchymosis, and coldness in patients with peripheral varicose vein: A multicenter assessment and validation study (VEIN-VIOLET study).

Objectives: We aimed to evaluate peripheral varicose vein symptoms including ecchymosis and coldness by using the Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms (VEINES-QoL/Sym) questionnaire.

Methods: A total of 1120 patients were enrolled to the analysis after the exclusion of 199 patients who did not match the inclusion criteria. Patients were asked to answer the VEINES-Sym questionnaire and questions about ecchymosis and coldness.

Dendritic cell activation is blunted in patients with coronary artery disease and diabetes mellitus.

Background: It has been shown that functional status of dendritic cells (DCs) in diabetic patients with unstable angina pectoris (UAP) are more mature and activated than diabetic patients without coronary artery disease (CAD) and none diabetic patients with UAP. Accordingly we aimed to assess the activation of DCs in patients with CAD with/and without Diabetes Mellitus (DM) and compare to those in subjects with normal coronary arteries (NCA).

Materials And Methods: Twenty three patients with severe CAD who were scheduled to coronary artery by-pass grafting surgery and 6 patients with angiographycally NCAs were included in the study.

Inflammation in Coronary Artery Ectasia Compared to Atherosclerosis.

We have read with great enthusiasm the article recently published by Boles et al. [..

Ecchymosis: A novel sign in patients with varicose veins.

Background: In the absence of trauma, hematologic disease and anti-platelet use, no attention has been paid to elucidate the mechanism of ecchymosis. It has taken our attention that ecchymosis on lower limb might be a sign of varicose vein. Accordingly, we aimed to analyze and describe the frequency of leg symptoms and presence of ecchymosis in patients with varicose vein.

Symptoms in supraventricular tachycardia: Is it simply a manifestation of increased heart rate?

A significant proportion of patients in clinical practice may not have ECG recordings of the index tachycardia (non-documented SVT), or only have recordings of limited diagnostic value. Despite the highly specified symptomatic and ECG diagnostic criteria, diagnosis and referral for ablation treatment is not always straightforward. Although ECG based diagnostic or treatment algorithms have been well defined in literature, we need a symptom based diagnostic algorithm or scoring system in patients with suspected supraventricular arrhythmia.