A new nano approach to prevent tumor growth in the local treatment of glioblastoma: Temozolomide and rutin-loaded hybrid layered composite nanofiber.

Total resection of glioblastoma (GB) tumors is nearly impossible, and systemic administration of temozolomide (TMZ) is often inadequate. This study presents a hybrid layered composite nanofiber mesh (LHN) designed for localized treatment in GB tumor bed. The LHN, consisting of polyvinyl alcohol and core-shell polylactic acid layers, was loaded with TMZ and rutin.

Validity and reliability study of the Turkish version of the quiet quitting scale in healthcare workers.

This study aimed to assess the reliability and validity of the Turkish version of the Quiet Quitting Scale (QQS) among healthcare workers. After completing the language validation, the psychometric properties of the QQS were tested on a sample of 542 healthcare workers from two hospitals in Turkey. Convergent validity was examined using the Burnout Measure-Short Version (BMS).

Does thiol-disulphide balance in tissue and serum play a role in disease management in ureteropelvic junction stenosis?

Background: The study aimed at evaluating the role of thiol-disulphide balance parameters [native thiol (SH), total thiol (SH + SS), disulphide (SS), disulphide/native thiol ratio (% SS/SH), disulphide/total thiol ratio (% SS/Total Thiol) and native thiol/total thiol ratio (%SH/Total Thiol)], which are important oxidative stress markers in the congenital ureteropelvic junction (UPJ) stenosis, in the diagnosis of the disease, and its role in determining the need for surgery and follow-up.

Materials And Methods: This prospective study included 30 children diagnosed with congenital intrinsic ureteropelvic junction obstruction (UPJO) and a control group of 30 healthy children admitted to the pediatric clinic between January 2016 and February 2017. The children with UPJO underwent laparoscopic dismembered pyeloplasty.

Effects of Curcumin and Its Analogue Desmethoxycurcumin on miR-133b and Its Target Gene GSTP-1 in Cisplatin-resistant Ovarian Cancer Cells.

Background/aim: Ovarian cancer, despite being the fifth most common gynecological malignancy, has the highest mortality rate. Recent clinical studies have explored the potential of natural products, like curcumin (CUR), to enhance conventional chemotherapy by targeting multiple cellular pathways. This study aimed to evaluate the effects of CUR and its analog, demethoxycurcumin (DMC), on human ovarian cancer and cisplatin-resistant ovarian cancer cell proliferation and apoptosis.

Green Synthesis of Ag and Cu Nanoparticles Using Ehrh Extract: Coating, Characterization, and Bioactivity on PEEK Polymer Substrates.

PEEK-based implant materials have gained increasing attention as an alternative to titanium due to their biocompatibility and bone-like elasticity. However, PEEK's surface quality and wear resistance are lower than those of metals. This study aimed to enhance the bioactivity and surface quality of PEEK by coating it with silver and copper nanoparticles synthesized via a green method using Ehrh.

DiMA: sequence diversity dynamics analyser for viruses.

Sequence diversity is one of the major challenges in the design of diagnostic, prophylactic, and therapeutic interventions against viruses. DiMA is a novel tool that is big data-ready and designed to facilitate the dissection of sequence diversity dynamics for viruses. DiMA stands out from other diversity analysis tools by offering various unique features.

Twenty year outcomes following short-segment posterior instrumentation and fusion for thoracolumbar burst fractures: A retrospective observational study.

This study reviews the long-term efficacy of short-segment posterior instrumentation and fusion (SSPIF) in treating thoracolumbar burst fractures. Authors retrospectively reviewed the radiographic results of single-level thoracolumbar burst fractures treated by SSPIF. Vertebral body height and wedge angles were measured on the preoperative, postoperative, and follow-up radiographic images.

Effect of Laparoscopic Sleeve Gastrectomy on Calcium Metabolism Parameters, Vitamin D, and Parathyroid Hormone in Morbidly Obese Patients: Short-Term Results.

Objective: Sleeve gastrectomy (SG) is a widely utilized bariatric surgical procedure. It may affect various aspects of nutritional and metabolic health, including calcium (Ca) metabolism, vitamin D levels, and parathyroid hormone (PTH) secretion. We aimed to investigate the effect of laparoscopic SG (LSG) on Ca metabolism parameters, vitamin D, and PTH in morbidly obese patients.

Pembrolizumab-Induced Addison's Disease Leading to Severe Hyponatremia in a Breast Cancer Survivor: A Case Report With Implications for Emergency Department Practice.

Pembrolizumab, a PD-1 inhibitor, has become a cornerstone in the treatment of various cancers, including breast cancer. However, its use is associated with immune-related adverse effects (irAEs), particularly those involving the endocrine system. This case report presents a rare instance of pembrolizumab-induced Addison's disease leading to severe hyponatremia.

Should Gallbladder Pathologies Be Investigated in Patients With Colon Polyps?

Background Data regarding the frequency of development of gallbladder pathologies in patients with colon polyps are quite limited and heterogeneous. Hence, this study aimed to investigate whether colon polyps cause an increased risk of developing gallbladder pathologies and the necessity of ultrasonographic screening. Methodology This retrospective, cross-sectional study was conducted among adult patients who underwent a colonoscopy and hepatobiliary ultrasound as part of their health check-up from January 2018 to January 2023.

Effects of quercetin-immobilized albumin cerium oxide nanoparticles on glutamate toxicity: in vitro study.

One aspect of glutamate (Glut) toxicity may be the opening of the blood-brain barrier to albumin (Al), which in itself can cause nerve cell death. Quercetin (Q) is a polyphenolic substance and has a neuroprotective effect. Cerium oxide nanoparticles (CeONPs) are highly interested in biological applications due to their antioxidant properties.

Case report: Bladder stone caused by dislocated Cu-IUD.

Introduction And Importance: The intrauterine device, usually in the form of a copper IUD or levonorgestrel intrauterine system, is a widely used contraceptive method. The risk of uterine perforation is low and ranges from 0.3 to 2.

The relationship between the online learning process, 21st century skills and work readiness in senior nursing students.

Aim: The aim of this study was to: a) develop scales that measure nursing students' perceptions of the online learning process and the effects of this process on nursing knowledge and skills and b) explain the relationship between these scales, 21st century skills and work readiness.

Background: Twenty-first century skills include learning and innovation skills, information, media and technology skills and life and career skills. These skills have come to the fore through nursing education's adoption of online education after recent global events such as the COVID-19 restrictions.

Ameliorating effect of S-Allyl cysteine (Black Garlic) on 6-OHDA mediated neurotoxicity in SH-SY5Y cell line.

Therapeutic approaches based on isolated compounds derived from natural products are more common in preventing diseases involving inflammation and oxidative stress at present. S-allyl cysteine (SAC) is a promising garlic-derived organosulfur compound with many positive effects in cell models and living systems. SAC has biological activity in various fields, enclosing healing in learning and memory disorders, neurotrophic effects, and antioxidant activity.

Evaluation of Splint and Exercise Interventions for Carpal Tunnel Syndrome: Insights from Ultrasonographic Measurements.

BACKGROUND Carpal tunnel syndrome (CTS) is a neuropathy caused by the entrapment of the median nerve, which requires effective management strategies. The median nerve is subjected to pressure within the carpal tunnel, resulting in tingling, numbness, and pain in the median side of the hand. We compared the efficacy of splint use with an exercise program vs exercise alone in patients with mild and moderate CTS.

Evaluation of the results of closed kinetic chain exercises applied in the conservative treatment of patellofemoral pain syndrome by means of shear wave elastography: A randomized controlled trial.

Purpose: Non-selective closed kinetic chain exercises (NSKCE) and or selective closed kinetic chain exercises (SCKCE) has been shown to increase Vastus medialis obliquus (VMO) muscle power in patellofemoral pain syndrome (PFPS). However, the superiority of the exercises to each other has not been shown. This study aimed to evaluating the effects of different exercises on the stiffness of the VMO and vastus lateralis (VL) muscles, pain management, functional scores, and thigh circumferences.

Effect of boswellia () supplementation on glycemic markers and lipid profile in type 2 diabetic patients: a systematic review and meta-analysis.

Background: Type 2 diabetes mellitus (T2DM) is a significant global health challenge whose prevalence is projected to increase alarmingly. Recently, due to better safety and fewer adverse effects, herbal medicines have been used to manage T2DM. This study aimed to evaluate the efficacy of boswellia in improving glycemic markers and lipid profiles in T2DM patients.

Love of life and flourishing in Turkish youth: mediating effects of optimism and hope.

The concept of love of life, which refers to a positive attitude towards one's own life, care for it and attachment to it, has recently captured the attention of researchers in the field of positive psychology. Despite its growing importance, there is a lack of research investigating the underlying mechanisms through which love of life impacts the flourishing and well-being of individuals. For the first time, the present study examined the mediating roles of optimism and hope in the association between love of life and flourishing in Turkish youth.

The effect of posture regulation training on musculoskeletal disorders, fatigue level and job performance in intensive care nurses.

Background: Intensive care units (ICUs) are one of the high-risk working areas in terms of musculoskeletal disability and ergonomic risks including the environment and posture factors. Correct posture technique is often ignored by nurses working in these units. This study was conducted to determine the effect of posture regulation training on work-related musculoskeletal disorders, fatigue level and job performance in nurses working in ICUs.