3 results match your criteria: "Yellow River Hospital Attached Henan University of Science and Technology[Affiliation]"
Autophagic degradation of CDK4 is responsible for G0/G1 cell cycle arrest in NVP-BEZ235-treated neuroblastoma.
Cancer Biol Ther
December 2024
Department of Oncology, Shanghai ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: CDK4 is highly expressed and associated with poor prognosis and decreased survival in advanced neuroblastoma (NB). Targeting CDK4 degradation presents a potentially promising therapeutic strategy compared to conventional CDK4 inhibitors. However, the autophagic degradation of the CDK4 protein and its anti-proliferation effect in NB cells has not been mentioned.
View Article and Find Full Text PDFCombined transjugular/percutaneous intrahepatic portosystemic shunts (cTIPS) for cavernous transformation of the portal vein after conventional transjugular approach TIPS failure.
Medicine (Baltimore)
April 2023
Yellow River Hospital Attached Henan University of Science and Technology, Sanmeixia, China.
This study aim was to compare the safety and efficacy of combined transjugular/percutaneous intrahepatic portosystemic shunts (cTIPS) and transjugular intrahepatic portosystemic shunt (TIPS) in cirrhotic patients with cavernous transformation of the portal vein (CTPV) after conventional transjugular approach TIPS failure. Cirrhotic patients who were diagnosed as CTPV and treated by cTIPS or TIPS between July 2012 and April 2022 were retrospectively analyzed. Patients' characteristics and clinical data were recorded.
View Article and Find Full Text PDFTiron Inhibits UVB-Induced AP-1 Binding Sites Transcriptional Activation on MMP-1 and MMP-3 Promoters by MAPK Signaling Pathway in Human Dermal Fibroblasts.
PLoS One
August 2017
Institute of Oncology, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- * The study shows that Tiron can inhibit the expression of matrix metalloproteinases (MMP)-1 and MMP-3 in human dermal fibroblast cells when exposed to ultraviolet B (UVB) radiation.
- * Tiron works by blocking the activation of the MAPK signaling pathway and the AP-1 protein, which leads to reduced expression of MMP-1 and MMP-3, suggesting its potential in preventing skin aging caused by UV exposure.