MiR-762 regulates the activation of PI3K/AKT and Hippo pathways involved in the development of gastric cancer by targeting LZTS1.

Objective: MiR-762 has been confirmed as a tumor promoter in multiple tumors, while few reports illustrate its role in gastric cancer (GC). Thus, this research aimed to investigate whether miR-762 is involved in GC development.

Methods: MiR-762 expression in the tumor tissues from GC patients and GC cell lines was analyzed by qRT-PCR.

Silencing of TLR7 protects against lipopolysaccharide-induced chondrocyte apoptosis and injury by blocking the p21-mediated JAK2/STAT3 pathway.

Involvement of toll-like receptor 7 (TLR7) in the immune response has been reported in diverse inflammatory diseases. However, the role of TLR7 in the pathogenesis of osteoarthritis (OA) is poorly understood. In this study, we sought to investigate the contribution of TLR7 in regulating chondrocyte apoptosis, inflammation, and degradation of the extracellula matrix (ECM), and its underlying mechanisms.

Microcystic urothelial carcinoma: a case report.

Microcystic urothelial carcinoma (MUC) is a rare variant of urothelial carcinoma that is highly aggressive with poor prognosis. Due to the scarcity of cases, its histologic morphology and immunohistochemical characteristics are still not clear. This paper reports a 71-year old female patient with gross hematuria and abdominal pain.

Apatinib inhibits macrophage-mediated epithelial-mesenchymal transition in lung cancer.

Chemotherapy is one of the main treatment approaches for lung cancer. However, few drugs can be used in the post-first-line treatment of lung cancer. Apatinib is a small molecule inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) and is widely used in advanced gastric cancer.

Three-dimensional image navigation system-assisted anterior cervical screw fixation for treatment of acute odontoid fracture.

This study is to investigate the role of three-dimensional image navigation system for surgical treatment of odontoid fracture. A total of 21 patients were enrolled in this study. The anterior cervical hollow screw fixation was performed for treatment of acute odontoid fracture under monitoring of isocentric C-arm three-dimensional navigation system (Iso-C 3D) navigation system.