Bioaugmented design and functional evaluation of low damage implantable array electrodes.

Implantable neural electrodes are key components of brain-computer interfaces (BCI), but the mismatch in mechanical and biological properties between electrode materials and brain tissue can lead to foreign body reactions and glial scarring, and subsequently compromise the long-term stability of electrical signal transmission. In this study, we proposed a new concept for the design and bioaugmentation of implantable electrodes (bio-array electrodes) featuring a heterogeneous gradient structure. Different composite polyaniline-gelatin-alginate based conductive hydrogel formulations were developed for electrode surface coating.

Enhanced CAD Detection Using Novel Multi-Modal Learning: Integration of ECG, PCG, and Coupling Signals.

Early and highly precise detection is essential for delaying the progression of coronary artery disease (CAD). Previous methods primarily based on single-modal data inherently lack sufficient information that compromises detection precision. This paper proposes a novel multi-modal learning method aimed to enhance CAD detection by integrating ECG, PCG, and coupling signals.

Efficient biodegradation of poly(butylene adipate-co-terephthalate) in mild temperature by cutinases derived from a marine fungus.

Poly(butylene adipate-co-terephthalate) (PBAT) waste gradually accumulates in the environment, posing ecological risks. Enzymatic hydrolysis holds great potential in the end-of-life management of PBAT, but reported enzymes require high reaction temperatures, limiting their practical industrial applications. In this study, we discovered that the marine fungus Alternaria alternata FB1 can efficiently degrade PBAT at 28 °C.

MXene-Based Skin-Like Hydrogel Sensor and Machine Learning-Assisted Handwriting Recognition.

Conductive hydrogels are widely used in flexible sensors owing to their adjustable structure, good conductivity, and flexibility. The performance of excellent mechanical properties, high sensitivity, and elastic modulus compatible with human tissues is of great interest in the field of flexible sensors. In this paper, the functional groups of trisodium citrate dihydrate (SC) and MXene form multiple hydrogen bonds in the polymer network to prepare a hydrogel with mechanical properties (Young's modulus (23.

Identification of AdipoRon analogues as novel activators of AMPK for the treatment of type 2 diabetes.

The activation of AMPK has emerged as a promising therapeutic approach for the treatment of metabolic diseases. AdipoRon, an agonist of the adiponectin receptor, has been identified as a compound capable of activating AMPK the adiponectin receptor. To identify novel AdipoRon analogues with AMPK activation potential, a total of 17 analogues were designed, synthesized, and subjected to biological evaluation.

Identification and expression analysis of Sox family genes in echinoderms.

The Sox gene family, a collection of transcription factors widely distributed throughout the animal kingdom, plays a crucial role in numerous developmental processes. Echinoderms occupy a pivotal position in many research fields, such as neuroscience, sex determination and differentiation, and embryonic development. However, to date, no comprehensive study has been conducted to characterize and analyze Sox genes in echinoderms.

Unveiling the role of political education for political participation in China.

It is a well-known fact that political education plays a pivotal role in shaping informed, engaged, and responsible citizens in a country. The empirical literature lacks the exploration of the impact of political education on political participation in addition to political efficacy and social media usage. This study investigates the interconnected relationship between political education, social media usage, political efficacy, and political participation in China.

Study on the influence of rock bridge angle on the size effect of rock uniaxial compression.

As a basic parameter of rock, the rock bridge angle plays an important role in maintaining the stability of rock masses. To study the size effect of rock bridge angle on the uniaxial compressive strength of rocks, this paper adopts the principle of regression analysis and combines numerical simulation to carry out relevant research. The research results indicate that: (1) the uniaxial compressive strength decreases with the increase of the rock bridge angle, showing a power function relationship; (2) The uniaxial compressive strength decreases with the increase of rock size and tends to stabilize when the rock size is greater than 350 mm, showing a significant size effect.

The acute neurotoxicity of inorganic mercury in Mactra chinensis philippi.

Inorganic mercury (IHg) is hazardous to marine organisms especially resulting in neurotoxicity, bivalves are sensitive to pollutants as "ocean sentinel", but data on the neurotoxicity of IHg in bivalves are sparse. So we chosed M. chinensis philippi with typical neural structures in bivalves to investigate the neurotoxicity of IHg, which could be helpful to understand the specificity of neural regulation and the response characteristics of bivalves.

Deciphering variations in the surficial bacterial compositions and functional profiles in the intersection between North and South Yellow Sea.

The coastal ocean systems play paramount role in the nutrient biogeochemistry because of its interconnected environment. To gain a novel insight into coupling relationships between bacterial community, functioning properties and nutrient metabolism, we conducted analysis on the patterns and driving factors of planktonic bacterial functional community across subsurface water of marine ranching near the Yellow Sea in both summer and winter. Illumina HiSeq Sequencing and a corresponding set of biogeochemical data were used to assess distribution patterns of taxa, adaptive mechanism and metabolic function.

Construction of a smart face recognition model for university libraries based on FaceNet-MMAR algorithm.

The continuous development of science and technology has led to the gradual digitization and intelligence of campus construction. To apply facial recognition technology to construct smart libraries in higher education, this study optimizes traditional facial recognition algorithm models. Firstly, a smart management system for university libraries is designed with facial recognition as the core, and secondly, the traditional FaceNet network is optimized.

Assessing the social cost of municipal solid waste management in Beijing: A systematic life cycle analysis.

The increased municipal solid waste generation poses ponderous pressure on the economy, environment, and public health. The current waste treatment process has multiple limitations. To inform policymakers on the best practices and feasibility, we develop a more comprehensive social costing model to assess the impacts of municipal solid waste management throughout its life cycle.

The Effect of Parenting Practices on Creativity: Mediating Role of Psychological Resilience.

Aim: This study aimed to investigate the relationship between parenting practices and creativity (both general and malignant creativity) in a representative sample of college students in China, and to explore the potential mediating role of resilience.

Methods: The study was conducted among 1201 Chinese college students who completed questionnaires on parenting practices, creativity, and resilience. The parenting practices were assessed using the short-form Egna Minnen av Barndoms Uppfostran for Chinese, while creativity was measured using the Malevolent Creativity Behavior Scale and the Runco Ideational Behavior Scale.

Synthesis, characterization and application of oligomeric proanthocyanidin-rich dual network hydrogels.

A structurally dense hydrogel, with strong hydrogen bonding networks, was formed from poly(vinyl alcohol), sodium alginate, and oligomeric proanthocyanidins, using a combination of freeze-thaw cycles and calcium ion cross-linking. The structure of the hydrogel was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. Mechanical testing and thermogravimetric analysis showed that incorporation of proanthocyanidins enhanced both the mechanical properties and the thermal stability of the hydrogel.

Genome-wide identification and comparative analysis of Dmrt genes in echinoderms.

The Dmrt (Doublesex-mab3-related transcription factor) gene family is a class of crucial transcription factors characterized by one or several conserved DM (Doublesex/Mab-3) domains. Dmrt family genes can participate in various physiological developmental processes, especially in sex determination/differentiation. Echinoderms are extremely important research objects in various fields, such as sex determination/differentiation and neuroscience.

Simple lignin-based, light-driven shape memory polymers with excellent mechanical properties and wide range of glass transition temperatures.

Lignin is the most abundant biomass source of aromatic hydrocarbons but, at present, is not effectively utilized. The development of simple and efficient methods for producing lignin-based polymers to replace petroleum-based products is an important strategy for promoting environmentally friendly and sustainable materials and controlling carbon emissions. In this work, lignin-based, light-driven shape memory polymers (ELIDs) with improved mechanical properties have been prepared from enzymatic hydrolysis lignin, itaconic acid and 1,12-dodecanediol, without any chemical modification of the lignin.

Experimental and numerical investigation of the transient thermal characteristics of twisted nitinol wires in a continuous torsional refrigeration system.

Twistocaloric cooling technology is a novel solid elastocaloric refrigeration to be promising alternatives to conventional compression refrigeration. The transient thermal characteristics of the twistocaloric-effect material and its cooling capacity are critical for this technology. A test rig of the continuous torsional refrigeration system (CTRS) using nitinol wires twisted by a stepping motor was built.

TXNIP Participated in NLRP3-Mediated Inflammation in a Rat Model of Cervical Spondylotic Myelopathy.

Background: Cervical spondylotic myelopathy (CSM) is a spinal cord disease caused by cervical disc degeneration and related pathological changes. Cervical spondylotic myelopathy may result from inflammation responses and neuronal damage. Thioredoxin-interacting protein (TXNIP)/NOD-like receptor protein 3 (NLRP3) signaling promotes inflammation.

[Study on the effect of Xiaoqinglong decoction on vascular endothelin inpulmonary hypertension rat based on Jiebiaokuoluo method].

Objective: To discuss the effect of Xiaoqinglong decoction on vascular endothelin (ET) in rats pulmonary hypertension (PAH) model based on the Jiebiaokuoluo method.

Methods: Sixty male SD rats were randomly divided into six groups: control group, PAH model group, positive drug group, and Xiaoqinglong decoction in the high-dose, medium-dose and low-dose groups, 10 rats in each group. The control group did not receive any treatment.

High lignin, light-driven shape memory polymers with excellent mechanical performance.

With the gradual global standardization of carbon emission policies, the development of renewable resources to replace traditional fossil resources is assuming increasing importance. Lignin is the most abundant natural source of aromatic compounds and has the potential to replace petroleum-based aromatic hydrocarbons. In this work, the rigid benzene ring structure and excellent photothermal properties of lignin were exploited to produce light-driven lignin-based shape memory polymers (ELEPs) that contain high proportions of lignin and have good mechanical properties.

Brain Network Alterations in Rectal Cancer Survivors With Depression Tendency: Evaluation With Multimodal Magnetic Resonance Imaging.

Surgery and chemotherapy may increase depression tendency in patients with rectal cancer (RC). Nevertheless, few comprehensive studies are conducted on alterations of brain network induced by depression tendency in patients with RC. Resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) data were collected from 42 patients with RC with surgery and chemotherapy and 38 healthy controls (HCs).

A Study on the Impact of Basketball on the Physical Fitness and Health of Adolescents Based on the Method of Correlation Analysis.

Basketball can improve physical fitness, keep healthy, and become the main form of modern sports. However, basketball generally has the problem of unreasonable sports schemes and even reduces physical fitness. Therefore, finding an effective basketball program is an urgent problem to be solved at present.