745 results match your criteria: "Yantai Affiliated Hospital of Binzhou Medical University[Affiliation]"

Capsaicin-induced Ca overload and ablation of TRPV1-expressing axonal terminals for comfortable tumor immunotherapy.

Nanoscale

December 2024

Institute of Rehabilitation Medicine, School of Rehabilitation Medicine, Binzhou Medical University, Yantai 264003, People's Republic of China.

As a common malignancy symptom, cancer pain significantly affects patients' quality of life. Approximately 60%-90% of patients with advanced cancer experience debilitating pain. Therefore, a comprehensive treatment system that combines cancer pain suppression and tumor treatment could provide significant benefits for these patients.

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Neuroinflammation and oxidative stress are key factors leading to neuronal injury. In this study, we investigated the role of S32, a novel 3-acetylaminocoumarin compound, in ameliorating neuronal injury induced by neuroinflammation and oxidative stress and . First, we found that S32 reduced the expression levels of p-P65 and p-P38, inhibited the nuclear translocation of P65, and lowered the levels of pro-inflammatory factors in LPS-induced BV2 cells, which indicated that S32 had an antineuroinflammatory effect.

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Article Synopsis
  • - A 32-year-old man with schizophrenia visited a gastroenterology clinic due to abdominal pain and unusual behavior; he had a large metallic object in his stomach found through a CT scan.
  • - He initially denied swallowing anything, and because the object was too large for endoscopic removal, doctors attempted laparoscopic surgery instead.
  • - The surgery required conversion to an open procedure, during which they successfully removed the metallic object and over 60 magnets, and he reported being symptom-free at a follow-up after one month.
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Tenecteplase thrombolytic therapy for acute ischaemic stroke in China: a real-world, multicentre, retrospective, controlled study.

Stroke Vasc Neurol

November 2024

Department of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.

Background And Aims: Tenecteplase (TNK) offers logistical advantages in stroke thrombolytic therapy with its single bolus administration compared with alteplase. We aim to investigate the real-world evidence regarding its safety and effectiveness in China.

Methods: We conducted a retrospective study on patients receiving alteplase or TNK for acute ischaemic stroke (AIS) within 4.

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Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) coexisting with pulmonary adenocarcinoma (ADC) is rare. Herein, we report a new case and review the cases published previously in the English literature. The clinicopathological features of similar cases reported in the English literature were summarized, and a putative association between DIPNECH and pulmonary ADC was suggested.

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Epilepsy is a common chronic neurological disorder with high prevalence that profoundly affects millions of people worldwide. Inflammatory dysregulation affects central nervous system disorders including epilepsy, and YTHDF1, the most common "reader" of m6A and m6A-binding protein, can attenuate the inflammatory response and activate PTEN, and here we aimed to investigate its effect on epilepsy through epigenetics. All mice were injected intraperitoneally with 12 mg/kg of sea manic acid to establish an epilepsy model, and the epileptic behaviors of the mice were classified into 6 grades; epileptic behaviors of grade 3 or above were defined as seizures, and consecutive epileptic seizures of more than 30 min were considered as successful modeling.

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Article Synopsis
  • The study aimed to identify factors influencing hyperuricemia (HUA) in different populations in Shandong Province and create a prediction model for early detection.
  • Data from 705 patients across five hospitals were analyzed using various statistical methods, including logistic regression and ROC curves, alongside machine learning techniques like random forest and support vector machines (SVM).
  • Significant risk factors identified included total protein, low-density lipoprotein cholesterol, and glucose, with the SVM model showing strong predictive ability (AUC of 0.875) for HUA diagnosis.
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Detection of H1N1 Influenza Virus in the Bile of a Severe Influenza Mouse Model.

Influenza Other Respir Viruses

October 2024

State Key Laboratory of Respiratory Health and Multimorbidity, National Center for Respiratory Medicine, China.

Article Synopsis
  • - The study investigates how the influenza virus can cause severe complications, including organ failure and sepsis, highlighting its detection in various organs during the 2009 pandemic, but with less focus on blood infections.
  • - Using a mouse model for severe H1N1 influenza, researchers found live influenza virus in bile and blood samples early in the infection, as well as viral components in liver tissues; however, no live virus was found in bile when administered directly.
  • - The research concluded that influenza can spread through the bloodstream, affecting the liver and altering metabolic pathways, specifically reducing a certain bile acid and down-regulating genes involved in fat metabolism and bile secretion.
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Article Synopsis
  • - The study identifies the lipolysis-stimulated lipoprotein receptor (LSR) as a key host factor that helps defend against SARS-CoV-2 infection, showing its importance for potential therapies and prevention strategies.
  • - Research methods included using various models like cell lines, intestinal tissues, and humanized mice, revealing that losing LSR increases susceptibility to SARS-CoV-2, while adding LSR can protect against the virus.
  • - Mechanistically, LSR prevents the SARS-CoV-2 Spike protein from binding to the ACE2 receptor, which is crucial for viral entry, and a peptide derived from LSR can block this interaction, suggesting a new therapeutic approach against COVID-19.
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  • A new high-throughput electrochemiluminescence (ECL) method for detecting iodide ions was developed, utilizing a hydrophobic ruthenium derivative mixed with polymer dots to enhance ECL intensity significantly.
  • The enhanced ECL emitters showed 18 times higher intensity than the original polymer dots and 220 times higher than other coreactant-dependent systems, making them highly effective for measurement.
  • This method achieved a notable detection range of 0.8 nM to 4 μM and is particularly valuable for applications in marine monitoring, nuclear security, and cancer treatment due to its specificity and resistance to radiation.
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A bibliometrics and visualization analysis of ropivacaine research from 2000 to 2023.

Front Med (Lausanne)

October 2024

Department of Anesthesiology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Aim: Bibliometric and data visualization methods were used to identify the current status, key areas, and emerging frontiers in ropivacaine research.

Methods: We conducted a comprehensive search of the Web of Science database for publications related to ropivacaine published from 2000 to 2023. The publication types were limited to original articles and reviews.

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Preliminary identification of somatic mutations profile in ACL injury.

Sci Rep

October 2024

Central Laboratories, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, 266071, Shandong Province, China.

Anterior cruciate ligament (ACL) injury is a common orthopedic disease with a high incidence, long recovery time, and often requiring surgical treatment. However, the susceptibility factors for ACL injury are currently unclear, and there is a lack of analysis on the differences in the ligament itself. Previous studies have focused on germline mutations, with less research on somatic mutations.

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Background: The efficacy of DL-3-n-butylphthalide (NBP) in the treatment of post-stroke cognitive impairment (PSCI) has been reported previously. However, the course of treatment that shows curative effect and cytokines predictive of the efficacy of NBP in the treatment of PSCI have not been systematically evaluated. This study aimed to assess the efficacy, course of treatment, and cytokines that can predict the effectiveness of NBP in treating poststroke cognitive impairment PSCI.

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The application of nanoparticles in delivering small RNAs for cancer therapy.

Discov Oncol

September 2024

Department of Breast and Thyroid Surgery, Affiliated Yantaishan Hospital of Binzhou Medical University, Yantai, Shandong, 264000, People's Republic of China.

Article Synopsis
  • Small molecular RNAs like microRNA (miRNA) and small interfering RNA (siRNA) are crucial in regulating gene expression, especially in cancer diagnostics and treatment.* -
  • miRNAs are involved in posttranscriptional regulation, while siRNAs can silence specific genes and inhibit tumor development by targeting proto-oncogenes.* -
  • Nanoparticles can protect small RNAs from degradation by RNAase, making them effective carriers for delivering these molecules in cancer therapies; the review covers their benefits, limitations, and applications.*
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Article Synopsis
  • Traditional neuroimaging studies often focus on group analyses, missing out on individual differences in brain connectivity, which is crucial for understanding major depressive disorder (MDD).
  • This study aims to combine individualized functional and structural connectivity with machine learning to differentiate between people with MDD and healthy controls.
  • A total of 182 MDD patients and 157 healthy controls were involved, using advanced imaging techniques and statistical tests to assess connectivity differences, leading to the development of a support vector machine model for classification.
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Previous studies have found alterations in the local regional homogeneity of brain activity in individuals diagnosed with major depressive disorder. However, many studies have failed to consider that even during resting states, brain activity is dynamic and time-varying. The lack of investigation into the dynamic regional homogeneity has hindered the discovery of biomarkers for depression.

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Unlabelled: To explore brain function alterations in chronic insomnia (CI). 65 CI patients and 48 healthy controls were included to analyze abnormal alterations in brain spontaneous activity using static regional homogeneity (sReHo) and dynamic regional homogeneity (dReHo) methods. CI patients focused on decreased sReHo in bilateral lingual gyrus, bilateral middle occipital gyrus, bilateral inferior occipital gyrus and right superior occipital gyrus; decreased dReHo in bilateral superior occipital gyrus, bilateral cortical area around the talus fissure, and right middle occipital gyrus.

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Molecular mechanisms and targeted therapy for the metastasis of prostate cancer to the bones (Review).

Int J Oncol

November 2024

Department of Urology, Yantai Affiliated Hospital of Binzhou Medical University, The Second Clinical Medical College of Binzhou Medical University, Yantai, Shandong 264100, P.R. China.

The incidence of prostate cancer (PCa) is increasing, making it one of the prevalent malignancies among men. Metastasis of PCa to the bones poses the greatest danger to patients, potentially resulting in treatment ineffectiveness and mortality. At present, the management of patients with bone metastasis focuses primarily on providing palliative care.

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Article Synopsis
  • * Key findings showed decreased activity in the left cuneus and right angular gyrus, while the right cerebellar_Crus1 had increased activity.
  • * Correlations were found between brain function measures and clinical assessments, indicating that altered brain functions could help evaluate the severity of heat stroke.
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Background: Diabetes mellitus type 2 (T2DM) is formed by defective insulin secretion with the addition of peripheral tissue resistance of insulin action. It has been affecting over 400 million people all over the world.

Aim: To explore the pathogenesis of T2DM and to develop and implement new prevention and treatment strategies for T2DM.

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The study aims to evaluate the prognosis and risk factors of sepsis-associated thrombocytopenia (SAT) among patients with coagulopathy, and to provide evidence of the relationship between adverse outcomes and potential risks. Patients with sepsis-associated coagulopathy were included in the study from January 2014 to December 2022. The primary outcome was sepsis-associated thrombocytopenia (platelet count less than 100 *10/L), which was evaluated by logistic regression models adjusted for demographic characteristics and comorbidities.

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