1 results match your criteria: "Yangzhou University Yangzhou Jiangsu 225009 China featherinwind81@163.com.[Affiliation]"
Preparation of a minocycline polymer micelle thermosensitive gel and its application in spinal cord injury.
Nanoscale Adv
September 2024
School of Medicine, Yangzhou University Yangzhou Jiangsu 225009 China
Article Synopsis
- Neuroprotection is crucial in treating spinal cord injuries (SCI), and minocycline (MC) has shown potential but suffers from low effectiveness due to instability and bioavailability issues.
- Researchers created a new micellar thermosensitive hydrogel (MCPP-M-gel) that safely encapsulates MC in a specialized polymer, enhancing its performance in rat models with SCI.
- The study found that MCPP-M-gel promotes neuronal regeneration and improves the expression of critical proteins associated with nerve repair, indicating its potential for future applications in treating SCI and other neurodegenerative conditions.