Using a visible light-triggered pH switch to activate nanozymes for antibacterial treatment.

Here, we develop a visible light-triggered platform to activate the biomimetic activity of CuS nanoparticles by incorporating a photoacid generator. Under visible-light illumination, the remarkable pH decrease, caused by the intramolecular photoreaction of the photoacid generator, activates the peroxidase-like activity of the CuS nanoparticles. This visible light-triggered pH switch meets the antibacterial demands of peroxidase mimics perfectly in bacteria-infected wounds.

MnO microspheres as an oxidase mimic for rapid detection of glutathione.

Exploiting a rapid and sensitive method for biomarker detection has important implications in the early diagnosis of diseases. Here, we synthesized MnO microspheres which worked as a nanozyme to exhibit outstanding oxidase-like activity for rapid colorimetric determination of glutathione (GSH). The MnO microspheres of about 800 nm in size could be prepared through a hydrothermal method, and we found that the as-prepared MnO microspheres could quickly oxidize 3,3',5,5'-tetramethylbenzidine (TMB) to its oxidized form (TMBox) in the absence of HO.