Transcribed ultraconserved noncoding RNA uc.160 acts as a negative regulator in gastric cancer.

Background: Transcribed ultraconserved regions (T-UCRs) are a subset of long noncoding RNAs. It has been reported that T-UCRs are dysregulated in cancers and play an important role in the development and progression of malignancies. uc.

Latitudinal effects on crown shape evolution.

Large variations in crown shape are observed across the globe, from plants with wide and deep crowns to those with leaves clustered at the top. While there have been advances in the large-scale monitoring of forests, little is known about factors driving variations in crown shape with environmental conditions. Previous theoretical research suggests a gradient in crown shape with latitude, due to the effects of sun angle.

Adsorption and reduction of hexavalent chromium on magnetic greigite (FeS)-CTAB: leading role of Fe(ii) and S(-ii).

In this study, a facile one-step route was used to synthesize a novel magnetic mesoporous greigite (FeS)-CTAB composite, which was utilized to remove hexavalent chromium (Cr(vi)). The optimized FeS-CTAB composite with a CTAB dosage of 0.75 g possessed the maximum specific surface, showing the highest Cr(vi) adsorption capacity of 330.

Convenient construction of tetrahydrochromeno[4',3':2,3]indolizino[8,7-]indoles and tetrahydroindolizino[8,7-]indoles one-pot domino reaction.

The functionalized tetrahydrochromeno[4',3':2,3]indolizino[8,7-]indoles were conveniently synthesized in high yields by one-pot domino reaction of tryptamines, alkyl propiolates and 2-aryl-3-nitro-2-chromenes. Under similar conditions, the one-pot reaction of tryptamines, alkyl propiolates and β-nitroalkenes resulted in functionalized tetrahydroindolizino[8,7-]indoles. The reaction mechanism involved sequential generation of β-enamino ester, Michael addition, Pictet-Spengler reaction and annulation process.

Preparation and application synthesis of magnetic nanocomposite using waste toner for the removal of Cr(vi).

In this study, a novel magnetic nanocomposite was prepared using waste toner (WT) through high temperature decomposition, and calcination was conducted in different atmospheres (air, ammonia, and vacuum). WT calcined in ammonia (WT(NH)), and it was then utilized as an efficient absorbent for the reduction of Cr(vi) in aqueous solutions; a batch experiment with different conditions was performed to investigate its Cr(vi) removal ability. The effects of two pH-regulating acid (HCl and HSO) treatments were also studied.

Zusanli (ST36) Acupoint Injection with Neostigmine for Paralytic Postoperative Ileus following Radical Gastrectomy for Gastric Cancer: a Randomized Clinical Trial.

: The Zusanli (ST36) acupoint has been associated with treatment of various gastrointestinal conditions. There have been no studies of acupuncture therapy for paralytic postoperative ileus (PPOI). Patients with PPOI following gastrectomy for gastric cancer were randomized to receive ST36 acupoint injection with neostigmine, gluteal intramuscular injection with 1.

Diastereoselective synthesis of dispirooxindoles [3+2] cycloaddition of azomethine ylides to 3-phenacylideneoxindoles and evaluation of their cytotoxicity.

The three-component reaction of 1,2,3,4-tetrahydroisoquinoline, isatins and 3-phenacylideneoxindoles in refluxing ethanol afforded dispiro[indoline-3,1'-pyrrolo[2,1-]isoquinoline-3',3'-indolines] (4a-4x) in good yields 1,3-dipolar cycloaddition of generated azomethine ylide with the exocyclic double bond of 3-phenacylideneoxindoles. H NMR spectra and single crystal structures indicated the reaction has high regioselectivity and diastereoselectivity. Furthermore, their biological activities have been preliminarily demonstrated by evaluation against mouse breast cancer cells 4T1 and human liver cancer cells HepG2 by MTT assay.

Circ-PAX2 promotes proliferation and metastasis by absorbing miR-186 in lung cancer cells.

Circ-RNAs are a type of non-coding-protein RNAs which act as an effector role in many physiological processes. However, the novel function of circ-PAX2 in lung carcinomas is still unidentified. The current study is to detect the expression of circ-PAX2 in lung squamous cell carcinoma (LSCC) tissues and the physiological functions of circ-PAX2.

FeO -Based Materials for Electrochemical Energy Storage.

Iron oxides (FeO ), such as FeO and FeO materials, have attracted much attention because of their rich abundance, low cost, and environmental friendliness. However, FeO , which is similar to most transition metal oxides, possesses a poor rate capability and cycling life. Thus, FeO -based materials consisting of FeO , carbon, and metal-based materials have been widely explored.

Tandem four-component reaction for efficient synthesis of dihydrothiophene with substituted amino acid ethyl esters.

The one-pot four-component reaction of aromatic aldehydes, malononitrile, 1,3-thiazolidinedione and ethyl glycinate hydrochloride in ethanol in the presence of triethylamine afforded -dihydrothiophene ureidoformamide derivatives in moderate to good yields. The other α-amino acid ethyl esters resulted in the corresponding diastereoisomeric dihydrothiophene derivatives with various molecular ratios. The functionalized thiophene derivatives were also successfully prepared by sequential dehydrogenation reaction with DDQ.

Effects of the inhibitor of glutamate decarboxylase on the development and GABA accumulation in germinating fava beans under hypoxia-NaCl stress.

Glutamate decarboxylase (GAD) is the key enzyme in GABA shunt, which catalyzes the α-decarboxylation of glutamate to produce GABA. A specific inhibitor for GAD is convenient to study the dynamic balances of GABA metabolism in plants. The inhibitor of GAD in germinated fava beans was screened, and its inhibitory effect on the growth and GABA accumulation in fava beans during germination under hypoxia-NaCl stress was investigated.

Graphitic-phase carbon nitride-based electrochemiluminescence sensing analyses: recent advances and perspectives.

Graphitic-phase carbon nitride (g-CN) materials are important polymeric and metal-free semiconductors, and have attracted extensive attention as emerging electrochemiluminescence (ECL) emitters due to their wonderful optical and electronic properties. The g-CN-based ECL sensing analysis, as a research hotspot in analytical chemistry, offers an exquisite pathway to monitor target analytes with the advantages of low background signal, high sensitivity, desirable controllability, and simple instrumentation. Herein, we briefly describe the current research status of g-CN-based ECL assays along with versatile signaling strategies, introduce the preparation methods and ECL emission mechanisms of g-CN-dependent emitters, summarize their ECL sensing applications from 2012 to now, highlighting with special examples of metal ion and small molecule detection, nucleic acid bioanalysis, immunoassay, protein sensing, and cell-related determination.

Zein regulating apatite mineralization, degradability, cells responses and osteogenesis of 3D-printed scaffold of n-MS/ZN/PCL ternary composite.

Bioactive and degradable scaffolds of nano magnesium silicate (n-MS)/zein (ZN)/poly(caprolactone) (PCL) ternary composites were prepared by 3D-printing method. The results showed that the 3D-printed scaffolds possessed controllable pore structure, and pore morphology, pore size, porosity and pore interconnectivity of the scaffolds can be efficiently adjusted. In addition, the apatite-mineralization ability of the scaffolds in simulated body fluids was obviously improved with the increase of ZN content, in which the scaffold with 20 w% ZN (C20) possessed excellent apatite-mineralization ability.

iTRAQ-based quantitative proteomic analysis of dark-germinated soybeans in response to salt stress.

Soybean germination under stressful conditions, especially salt stress, has been verified to be an effective way of accumulating gamma-aminobutyric acid (GABA) in dark-germinated soybeans. In this study, a combination of physiological characteristics and isobaric tags for relative and absolute quantitation (iTRAQ) in a proteomic-based approach was used to investigate the protein changes in dark-germinated soybeans under salt stress. A total of 201 differentially abundant proteins (DAPs) were identified and divided into 13 functional groups.

Effects of arbuscular mycorrhizal fungi on seedlings under salt-alkali stress and nitrogen deposition conditions: from osmotic adjustment and ion balance.

Nitrogen deposition and soil salinization-alkalization have become major environmental problems throughout the world. is the dominant, and considered the most valuable, species for grassland restoration in the Northeast of China. However, little information exists concerning the role of arbuscular mycorrhizal fungi (AMF) in the adaptation of seedlings to the interactive effects of nitrogen and salt-alkali stress, especially from the perspective of osmotic adjustment and ion balance.

Hierarchically Nanostructured Transition Metal Oxides for Lithium-Ion Batteries.

Lithium-ion batteries (LIBs) have been widely used in the field of portable electric devices because of their high energy density and long cycling life. To further improve the performance of LIBs, it is of great importance to develop new electrode materials. Various transition metal oxides (TMOs) have been extensively investigated as electrode materials for LIBs.

TUCR.454 inhabits metastasis in lung cancer cells.

Transcribed ultraconserved regions (TUCRs) belong to long non-coding RNAs (lncRNAs) are transcripts longer than 200 base pair RNA with no protein-coding capacity. Previous studies showed that TUCRs serve as oncogenes or tumor suppressor genes are involved in tumorigenesis and cancer progressive. However, little is known about the expression level and biological role of TUCR.

Serum miR-10a-5p and miR-196a-5p as non-invasive biomarkers in non-small cell lung cancer.

Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for about 85% of all cases. MicroRNAs are stable molecules in the blood and can be used as biomarkers for early diagnosis of various malignancies. The aim of this study was to evaluate expression of miR-10a-5p and miR-196a-5p in tissue and serum of patients with NSCLC and to explore its relationship with clinicopathological characteristics.

Steering Photoelectrons Excited in Carbon Dots into Platinum Cluster Catalyst for Solar-Driven Hydrogen Production.

In composite photosynthetic systems, one most primary promise is to pursue the effect coupling among light harvesting, charge transfer, and catalytic kinetics. Herein, this study designs the reduced carbon dots (r-CDs) as both photon harvesters and photoelectron donors in combination with the platinum (Pt) clusters and fabricated the function-integrated r-CD/Pt photocatalyst through a photochemical route to control the anchoring of Pt clusters on r-CDs' surface for solar-driven hydrogen (H) generation. In the obtained r-CD/Pt composite, the r-CDs absorb solar photons and transform them into energetic electrons, which transfer to the Pt clusters with favorable charge separation for H evolution reaction (HER).

Inflammatory cytokine profiles of serum and cerebrospinal fluid in Chinese children with hand, foot and mouth disease.

Objective: Hand, foot and mouth disease (HFMD) is mainly caused by enterovirus 71 (EV71) or coxsackie virus A16 infection. Severe HFMD with encephalitis is a life-threatening disease for children. This study aimed to examine the levels of a variety of inflammatory cytokines in HFMD patients.

Metabolic reprogramming induced by inhibition of SLC2A1 suppresses tumor progression in lung adenocarcinoma.

Lung adenocarcinoma (LAC) is one of the common reasons of cancer-related death with few biomarkers for diagnosis and prognosis. Solute carrier family 2 member 1 protein, SLC2A1, has been associated with tumor progression, metastasis, and poor prognosis in many human solid tumors. However, little is reported about its biological functions in lung adenocarcinoma.

Human influence on the temporal dynamics and spatial distribution of forest biomass carbon in China.

Global carbon cycles are impacted by human activity primarily via fossil fuel combustion and forest carbon budget alterations. In this study, the temporal dynamics and spatial distribution of forest biomass carbon (FBC) stock and density in China were analyzed to assess the large-scale effects of humans on FBC. The results indicated that from 1977 to 2013, the FBC stock increased by 62.

Circulating exosomes and exosomal lncRNA HIF1A-AS1 in atherosclerosis.

Background: Exosomes which mainly function in intercellular communication and lncRNA HIF1A-AS1 which can be transferred by exosomes, have been shown to play a significant role in atherosclerosis. This study aims to explore the diagnostic value of exosomes and exosomal lncRNA HIF in atherosclerosis.

Methods: Plasma sample from 35 patients with atherosclerosis and from 28 healthy adults were collected for further investigation.