Gut microbiomes of bigheaded carps and hybrids provide insights into invasion: A hologenome perspective.

Gut microbiomes play an essential role in host survival and local adaptation and thus can facilitate the invasion of host species. Biological invasions have been shown to be linked to the genetic properties of alien host species. It is thus plausible that the holobiont, the host, and its associated microbiome act as an entity to drive invasion success.

PADI2-Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1-Mediated SOX2 mRNA Stability in Endometrial Cancer.

Peptidylarginine deiminase II (PADI2) converts positively charged arginine residues to neutrally charged citrulline, and this activity has been associated with the onset and progression of multiple cancers. However, a role for PADI2 in endometrial cancer (EC) has not been previously explored. This study demonstrates that PADI2 is positively associated with EC proregression.

Comprehensive Genomic Investigation of Coevolution of genes in Strains via Nanopore Sequencing.

Horizontal gene transfer facilitates the spread of antibiotic resistance genes, which constitutes a global challenge. However, the evolutionary trajectory of the mobile colistin resistome in bacteria is largely unknown. To investigate the coevolution and fitness cost of the colistin resistance genes in wild strains, different assays to uncover the genomic dynamics of and in bacterial populations are utilized.

On-line separation/analysis of Rhodamine B dye based on a solid-phase extraction high performance liquid chromatography self-designed device.

A special self-designed device based on poly-1-vinyl-3-pentylimidazole hexafluorophosphate (PILs-C) solid-phase extraction and high performance liquid chromatography (HPLC) is proposed as a novel method for the on-line separation and analysis of Rhodamine B (RhB) dye. Single factor experiment design and orthogonal experiment design were used to optimize the experimental parameters, such as pH, the amount of PILs-C, sample volume, flow rate, eluent type, eluent concentration, eluent volume, and the flow rate of eluent. Under the optimized conditions, the linear range was 0.

Tanshinone IIA regulates fibroblast proliferation and migration and post-surgery arthrofibrosis through the autophagy-mediated PI3K and AMPK-mTOR signaling pathway.

Post-surgery arthrofibrosis is one of the most restrictive factors in the development of intra-articular surgery and has presented tremendous obstacles for most orthopaedic surgeons. Tanshinone IIA (Tan IIA), a key active ingredient of Den-shen, has been used to treat fibrosis-related diseases, such as pulmonary, hepatic and myocardial fibrosis. In the present study, we aimed to investigate the effects of Tan IIA on post-surgery arthrofibrosis and .

A weak post-acidification UV mutant with improved textural properties.

To derive a mutant of SH2-1 with the capacity of weak postacidification and high texturing, first, taking frs4-1 and grx02 as the controls, H-ATPase activity was demonstrated to be highly related to the postacidification of SH2-1. Then, by detecting H-ATPase activity, the weak postacidify mutant of SH2-1 (renamed as sh2-5-66) was selected from 80 UV mutants. The pH and acidity of the milk fermented with sh2-5-66 were separately 0.

Expression of JWA and XRCC1 as prognostic markers for gastric cancer recurrence.

Gastric cancer is one of the common gastrointestinal tumors. Tumor recurrence leads to a high death rate of gastric cancer. It is very important to find markers to effectively predict gastric cancer recurrence.

Activation of brain regions using task-state FMRI in patients with mild traumatic brain injury: a meta-analysis.

Activation likelihood estimation meta-analysis was performed to examine the activation characteristics of cognition-related brain regions in patients with mild traumatic brain injury (mTBI). The databases PubMed, Ovid, Cochrane Library, Google Scholar, CNKI, WFSD, and VIP were systematically searched. The software Ginger-ALE 3.

Reproduction of ectoparasitic mites in a coevolved system: spp.-Eastern honey bees, .

Parasite host shifts can impose a high selective pressure on novel hosts. Even though the coevolved systems can reveal fundamental aspects of host-parasite interactions, research often focuses on the new host-parasite relationships. This holds true for two ectoparasitic mite species, and , which have shifted hosts from Eastern honey bees, , to Western honey bees, , generating colony losses of these pollinators globally.

A new strategy for synthesizing silver doped mesoporous bioactive glass fibers and their bioactivity, antibacterial activity and drug loading performance.

A new strategy for preparing mesoporous metal-doped bioactive glass fibers (MBGFs) was designed, which included electrospinning and sulfonating mesoporous PS fibers, precipitating metal ions and bioactive glass sol-gel precursor into the mesoporous polystyrene (PS) fibers and calcinations. Silver-doped mesoporous BGFs (Ag-MBGFs) with a uniform diameter of 1-2 μm and a specific surface area of 40.22 m g were prepared as an example and characterized by SEM, XRD, TG, ICP and FTIR.

Magnetic graphene oxide-ultrathin nickel-organic framework composite for the extraction and determination of epoxiconazole in food samples.

In this work, a magnetic graphene oxide-ultrathin metal-organic framework composite (FeO@SiO-GO-Ni-MOF) was synthesized for the first time. Employing FeO@SiO-GO-Ni-MOF composite as extractant, a novel method for the separation and analysis of the pesticide epoxiconazole was established with the assistance of high performance liquid chromatography (HPLC). The adsorption mechanisms were studied including by adsorption kinetics, thermodynamic parameters and adsorption isotherms.

Raddeanin A suppresses lung cancer cell proliferation via induction of apoptosis and increased production of ROS.

At present, in vitro cell experiments have confirmed that RaddeaninA can effectively inhibit the proliferation of some tumor cells, but the effect of RaddeaninA on lung cancer cells has not been observed. Therefore, this study explored its effect on lung cancer cells and its mechanism of action. Human lung cancer cell lines were treated with serum-free medium and varied concentrations of Raddeanin A.

Anti-inflammatory activity of a water-soluble polysaccharide from the roots of purple sweet potato.

In this study, a water-soluble polysaccharide was isolated from purple sweet potato roots. The and anti-inflammatory effects of the polysaccharide were evaluated by lipopolysaccharide (LPS)-induced inflammatory RAW264.7 macrophages and mice, respectively.

Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune-Adjuvant.

Influenza poses a severe threat to global health. Despite the whole inactivated virus (WIV)-based nasal vaccine being a promising strategy for influenza protection, the mucosal barrier is still a bottleneck of the nasal vaccine. Here, a catalytic mucosal adjuvant strategy for an influenza WIV nasal vaccine based on chitosan (CS) functionalized iron oxide nanozyme (IONzyme) is developed.

The effect of DALI02 in reducing the oxidative stress and inflammatory response induced by high-fat diet of rats.

A long-term high-fat diet (HFD) leads to significant oxidative stress in the body and induces inflammation. A preliminary evidence suggests a potential therapeutic utility of probiotics for this condition. To evaluate the potential effect of DALI02 on the oxidative stress and inflammatory damage induced by HFD, we used a hyperlipidemic rat as a model fed with HFD.

Flumatinib versus Imatinib for Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia: A Phase III, Randomized, Open-label, Multi-center FESTnd Study.

Purpose: Flumatinib has been shown to be a more potent inhibitor of BCR-ABL1 tyrosine kinase than imatinib. We evaluated the efficacy and safety of flumatinib versus imatinib, for first-line treatment of chronic phase Philadelphia chromosome-positive chronic myeloid leukemia (CML-CP).

Patients And Methods: In this study, 394 patients were randomized 1:1 to flumatinib 600 mg once daily ( = 196) or imatinib 400 mg once daily ( = 198) groups.

Clinical Features of Patients With COVID-19 With Nonalcoholic Fatty Liver Disease.

Previous studies reported that coronavirus disease 2019 (COVID-19) was likely to result in liver injury. However, few studies investigated liver injury in patients with COVID-19 with chronic liver diseases. We described the clinical features in patients with COVID-19 with nonalcoholic fatty liver disease (NAFLD).

Postgraduate nursing internationality education: A study in establishing an English nursing course.

Aim: The study was to explore the significant influence of an English nursing course in nursing postgraduate internationalization education.

Design: A cross-sectional study.

Method: The research object included three grades (a total of 18) of nursing postgraduate students in the Nursing School of Yangzhou University.

miR-638 acts as an oncogene and predicts poor prognosis in renal cell carcinoma.

Objective: The aim of this study was to investigate the function and prognostic value of miR-638 in renal cell carcinoma (RCC).

Methods: Expression of miR-638 in RCC tissues and corresponding noncancerous tissues were examined by reverse transcription quantitative polymerase chain reaction (RT-qPCR). To explore the effects of miR-638 on cell migration, invasion, viability, and apoptosis of RCC cells, wound scratch, transwell, MTT, CCK-8, and flow cytometry assays were performed.

The simultaneous detection of the squamous cell carcinoma antigen and cancer antigen 125 in the cervical cancer serum using nano-Ag polydopamine nanospheres in an SERS-based lateral flow immunoassay.

The accurate analysis of tumor related biomarkers is extremely critical in the diagnosis of the early stage cervical cancer. Herein, we designed a novel and inexpensive surface-enhanced Raman scattering-based lateral flow assay (SERS-based LFA) strip with a single test line, which was applied for the rapid and sensitive quantitative simultaneous analysis of SCCA and CA125 in serum samples from patients with cervical cancer. In the presence of target antigens, the monoclonal antibody-coupled and Raman reporter-labeled nano-Ag polydopamine nanospheres (PDA@Ag-NPs) aggregated on the test line modified by the polyclonal antibody to form a double-antibody sandwich structure.

Protein-mediated sponge-like copper sulfide as an ingenious and efficient peroxidase mimic for colorimetric glucose sensing.

Strenuous efforts have been made to develop nanozymes for achieving the performance of natural enzymes to broaden their application in practice, but the fabrication of high-performance and biocompatible nanozymes facile and versatile approaches has always been a great challenge. Here, sponge-like casein-CuS hybrid has been facilely synthesized in the presence of amphiphilic protein-casein through a simple one-step approach. Casein-CuS hybrid exhibits substrates-dependent peroxidase-like activity.

Metformin Restores Tetracyclines Susceptibility against Multidrug Resistant Bacteria.

Highly persistent incidence of multidrug resistant (MDR) bacterial pathogens constitutes a global burden for public health. An alternative strategy to alleviate such a crisis is to identify promising compounds to restore antibiotics activity against MDR bacteria. It is reported that the antidiabetic drug metformin exhibits the potentiation effect on tetracycline antibiotics, particularly doxycycline and minocycline, against MDR , , , and .

studies of adhesion properties of six lactic acid bacteria isolated from the longevous population of China.

Six lactic acid bacteria (LAB), isolated from the intestinal tract of the longevous population, were prominent for their strong bacteriostatic ability. In this study, the adhesion properties of the six strains were determined to explore their potential to be used as probiotics. The hydrophobicity and aggregation activity were firstly detected and were varied from 14.

Revision of the structure of isochaetoglobosin D based on NMR analysis and biosynthetic consideration.

Isochaetoglobosin D is a new chaetoglobosin possessing a unique 3,4-substituted pyrrole ring isolated and named by Qiu , and it is different from any one of the 14 sub-types in the macrocyclic ring of chaetoglobosins classified in our previous work. Its chemical shift values, coupling constants and biosynthetic consideration implied that the proposed structure of isochaetoglobosin D was incorrect. In this report, based on detailed NMR data analysis together with biosynthetic consideration, the structure of isochaetoglobosin D is suggested to be revised to that of penochalasin C.

Shifts in potential geographical distribution of under climate change scenarios in China.

Climate change poses a serious threat to biodiversity. Predicting the effects of climate change on the distribution of a species' habitat can help humans address the potential threats which may change the scope and distribution of species. is a common fast-growing tree species often used in the ecological restoration of riverbanks and alpine forests in central and eastern China.