716 results match your criteria: "Yanbian University Hospital[Affiliation]"

Background: The results of observational studies indicate a potential link between Helicobacter pylori infection and Sjogren's syndrome (SS), but the causal relationship between them remains unknown. This study applied Mendelian randomization (MR) to evaluate this relationship.

Method: Genome-wide association study (GWAS) summary statistics on H.

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Article Synopsis
  • The study evaluates the role of nutrition and immune-related biomarkers in predicting outcomes for patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant therapy and surgery, an area with limited evidence.
  • A total of 214 patients were analyzed and categorized based on their prognostic nutritional index (PNI), with findings indicating that lower PNI values correlate with reduced disease-free and overall survival rates.
  • Specifically, a low PNI was linked to worse 5-year disease-free survival (DFS) and overall survival (OS), suggesting that PNI could be a significant predictor of recurrence and mortality in LARC patients.
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The relationship between clinical outcomes and various factors influencing pregnancy was analyzed to provide reference data for patients and clinicians when selecting embryo transfer protocols. This was a retrospective study of 1309 transfer cycles between June 1, 2018, and May 1, 2023, in the Reproductive Medicine Center. Univariate analysis was performed on various factors that may have affected pregnancy outcomes, and further regression analysis was performed on those factors found by univariate analysis to correlate positively with clinical pregnancy outcomes.

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Background: One of the main illnesses in the globe that causes impairment and death in people is stroke. In the globe today, it ranks as the second leading cause of death and the leading cause of death in China.

Objective: This paper analyses into the critical role of risk perception in developing individual awareness of stroke risk and encouraging proactive preventive health behaviors, essential for effective primary stroke prevention strategies and reduced stroke incidence.

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The relationship between molybdenum and kidney-related disease outcomes, including hyperuricemia, is not well investigated. This study aims to determine whether molybdenum and its antioxidative property are associated with systemic inflammation and kidney-related disease parameters including hyperuricemia. Urinary molybdenum's epidemiological relationship to hyperuricemia and kidney-disease related outcomes was evaluated in 15,370 adult participants in the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2016.

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Background/aim: Cancer-associated fibroblasts (CAFs) have recently been suggested as critical cellular components of bone invasion in oral squamous cell carcinoma (OSCC). However, the underlying molecular mechanisms and subtypes related to their bone-invasive function are unclear. This study investigated the implications of thymidine phosphorylase (TP)-positive CAFs (TPCAFs) in OSCC bone invasion.

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Foritinib in advanced ROS1-rearranged non-small-cell lung cancer in China: a multicentre, open-label, single-arm, phase 2 study.

Lancet Respir Med

September 2024

Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. Electronic address:

Article Synopsis
  • - The study evaluates foritinib, a new treatment for patients with advanced ROS1-rearranged non-small-cell lung cancer (NSCLC), aiming to improve upon existing therapies that struggle with brain activity or safety.
  • - Conducted in China, the two-part clinical trial involved 104 patients with varying previous treatments and aimed to assess the drug's effectiveness and safety through objective response rates and safety assessments.
  • - Initial findings, gathered over nearly three years, monitored patient outcomes and noted adjustments in study protocols, particularly regarding participant eligibility related to prior ROS1 inhibitor use.
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This study was conducted to compare the changes in different clinical scores and imaging indexes of patients who underwent robot-assisted total knee arthroplasty (RA-TKA) and manual total knee arthroplasty (M-TKA). PubMed, Web of Science, Cochrane Library and Embase were searched according to PRISMA guidelines in June 2024. Search terms included "robot-assisted", "manual" and "total knee arthroplasty".

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  • - This study investigates the relationship between various immune cell types and biliary tract cancer, using Mendelian randomization to identify potential causal links and improve understanding of immune roles in this cancer type! - Utilizing data from genome-wide association studies (GWAS), the research analyzed 731 immune cell phenotypes and found a significant association between 26 immune cell types and the risk of developing biliary tract cancer! - The identified immune cell types included primarily 13 types of B cells, three classical dendritic cells, one mature T cell type, six regulatory T cells, and three myeloid cells, highlighting the diversity of immune cells potentially influencing cancer risk!
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  • Kidney Renal Clear Cell Carcinoma (KIRC) is a rising malignant tumor, with EBP1 being upregulated in various cancers but its role in KIRC previously unexplored.
  • * Research methods included analyzing EBP1 expression in kidney tissues, knocking it down in KIRC cell lines, and conducting various assays to assess its impact on tumor characteristics like proliferation and invasion.
  • * Results indicated that EBP1 is linked to worse clinical outcomes in KIRC and appears to promote cancer progression through the p38/HIF-1α signaling pathway.
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A dried sweat spot paper (DSSP) method based on novel mass spectrometry probe labeling for detection and resolution of DL-lactate enantiomers as potential biomarkers for diabetes mellitus.

Anal Chim Acta

August 2024

Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Department of Pharmaceutical Analysis, College of Pharmacy Yanbian University, Department of Pharmacy, Yanbian University Hospital, Yanji, 133002, Jilin Province, China. Electronic address:

Background: Human sweat can be collected non-invasively with low infectivity; however, its application as a determination method has been challenged due to the presence of trace amounts of chiral metabolites. Moreover, its application as a biological fluid for disease diagnosis has not been previously reported. In this study, the human dried sweat spot paper (DSSP) method was proposed for the derivatization of a novel mass spectrometric chiral probe, N-[1-Oxo-5-(triphenylphosphonium) pentyl]-(S)-3-aminopyrrolidine (OTPA), determination and resolution of DL-lactic acid (DL-LA) enantiomers in human elbow sweat.

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Residual intravenous foreign bodies following hand trauma are relatively rare; only a few previous reports of this situation are available. It has been reported that foreign bodies often migrate to the heart and atrium dextrum. Herein, we report a recent case of needle breakage in the dorsal vein of the hand that was removed with lignification using an intraoperative C-arm fluoroscopy machine and tape tourniquet to avoid proximal movement during removal.

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Background: With the increase in the number of low birth weight infants, oxygen therapy is more widely used. However, chronic high-concentration oxygen environments lead to hyperoxic lung injury in children, which in turn leads to bronchopulmonary dysplasia (BPD). PGE1 is widely used in the clinic for its ability to inhibit inflammation and improve circulation.

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Ethnopharmacological Relevance: Alcoholic depression, a disorder of the central nervous system, is characterized by alcohol abuse, which causes blood-brain barrier disruption and oxidative damage in the brain. The rhizome of Rhodiola crenulate, from which Dazhu Hongjingtian Injection (DZHJTI) is derived, has been traditionally employed in ethnopharmacology to treat neurological disorders due to its neuroprotective, anti-inflammatory, and antioxidant properties. However, the exact mechanism by which DZHJTI alleviates alcoholic depression remains unclear.

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Overview of multifunctional Tregs in cardiovascular disease: From insights into cellular functions to clinical implications.

FASEB J

July 2024

Department of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, P.R. China.

Regulatory T cells (Tregs) are crucial in regulating T-cell-mediated immune responses. Numerous studies have shown that dysfunction or decreased numbers of Tregs may be involved in inflammatory cardiovascular diseases (CVDs) such as atherosclerosis, hypertension, myocardial infarction, myocarditis, cardiomyopathy, valvular heart diseases, heart failure, and abdominal aortic aneurysm. Tregs can help to ameliorate CVDs by suppressing excessive inflammation through various mechanisms, including inhibition of T cells and B cells, inhibition of macrophage-induced inflammation, inhibition of dendritic cells and foam cell formation, and induction of anti-inflammatory macrophages.

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This study analysed the incidence of lower extremity amputation and its associated risk factors in patients with diabetic foot ulcers. This study systematically searched both Chinese and English databases, including CNKI, Wanfang, VIP, PubMed, EMBASE and Web of Science, to identify cohort studies related to lower extremity amputation and associated risk factors in patients with diabetic foot ulcers up to October 2023. The patients were stratified based on whether they underwent lower extremity amputation, and relevant data, including basic information, patient characteristics, complications, comorbidities and pertinent laboratory test data, were extracted from the included studies.

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Immunotherapy combined with chemotherapy regimen has been shown to be effective in recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). However, due to the small number of patients, its efficacy remains controversial in Asian populations, particularly in mainland China. Here a randomized, double-blind phase 3 trial evaluated the efficacy and safety of finotonlimab (SCT-I10A), a programmed cell death 1 (PD-1) monoclonal antibody, combined with cisplatin plus 5-fluorouracil (C5F) for the first-line treatment of R/M HNSCC.

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Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the colony formation assay data shown in Fig. 7A on p. 1183 were strikingly similar to data appearing in different form in the following article written by different authors at different research institutes that had already been published prior to its date of submission: Lou L, Chen G, Zhong B and Liu F: polysaccharide induced apoptosis and inhibited proliferation in infantile hemangioma endothelial cells via down‑regulation of PI3K/AKT signaling pathway.

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Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized inflammatory imbalance, intestinal epithelial mucosal damage, and dysbiosis of the gut microbiota. polysaccharides (PCPs) can regulate gut microbiota and inflammation. Here, the different doses of PCPs were administered to dextran sodium sulfate-induced UC mice, and the effects of the whole PCPs were compared with those of the fractionated fractions PCP-1 (19.

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Cisplatin (DDP) is a basic chemotherapy drug for gastric cancer (GC). With the increase of DDP drug concentration in clinical treatment, cancer cells gradually became resistant. Therefore, it is necessary to find effective therapeutic targets to enhance the sensitivity of GC to DDP.

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Article Synopsis
  • - Prostate cancer (PC) is a significant health issue for men, with the androgen-independent variant being particularly challenging due to its slow progression and resistance to hormone therapy.
  • - Mortalin, an oncogene, plays a crucial role in tumor migration and invasion, and its expression is found to be increased in prostate cancer tissues.
  • - Research indicates that Mortalin influences the epithelial-mesenchymal transition (EMT) through the Wnt/β-catenin signaling pathway, suggesting it could be a valuable target for new immunotherapy approaches in treating prostate cancer.
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Salidroside (SAL), a phenylpropanoid bioactive compound, has various pharmacological properties, including antioxidant, anti-inflammatory, and hepatoprotective effects. However, the pharmacological effects and mechanisms of action of SAL on cholestatic liver injury are unclear. This study investigated the mechanism and effects of salidroside (SAL) on intestinal flora distribution and hepatic stellate cell (HSC) activation in cholestatic hepatic fibrosis.

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