716 results match your criteria: "Yanbian University Hospital[Affiliation]"
Med Ultrason
December 2024
Department of Medical Ultrasound, Yanbian University Hospital, Yanji, Jilin, China.
Med Ultrason
December 2024
Department of Medical Ultrasound, Yanbian University Hospital,Yanji, Jilin, China.
ACS Appl Mater Interfaces
December 2024
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Protein corona (PC) formation confers novel biological properties to the original nanomaterial, impeding its uptake and targeting efficacy in cells and tissues. Although many studies discussing PC formation have focused on inert proteins that may inhibit the function of nanomaterials, some functional plasma proteins with intrinsic targeting capabilities can also be adsorbed to the surface of nanomaterials, with active ligand properties to improve the targeting ability. In this approach, nanomaterials are surface-engineered to promote the adsorption of specific functional plasma proteins that are directly targeted to transport nanomaterials to the target site.
View Article and Find Full Text PDFPhytomedicine
December 2024
Key Laboratory Pathobiology, State Ethnic Affairs Commission, Yanbian University, Yanji 133000, PR China. Electronic address:
Background: Pancreatic cancer (PC) is a malignant tumor with complex development mechanisms and a poor prognosis. Taraxasterol (TAX), a pentacyclic triterpenoid plant sterol derived from Taraxacum mongolicum, has multiple biological activities including an anti-tumor effect. However, the mechanism by which TAX exerts its anticancer effects in PC remains unclear.
View Article and Find Full Text PDFiScience
December 2024
Stroke Center, Department of Neurology, Yanbian University Hospital, Yanji 133002, China.
Ischemic stroke has a high disability rate, which leads to irreversible neuronal death. The efficacy of conventional stroke treatments, including thrombolytic and neuroprotective therapies, is constrained by a number of factors, including safety concerns and inefficient drug delivery. The advent of nanomaterials has created new avenues for stroke therapy, facilitating enhanced pharmacokinetic behavior of drugs, effective drug accumulation at the target site, augmented therapeutic efficacy, and concomitant reduction in side effects.
View Article and Find Full Text PDFJ Craniofac Surg
December 2024
Department of Medical Cosmetology, Yanbian University Hospital, Yanji, Jilin, China.
Keloid is the result of abnormal wound healing, puzzled by the invasive growth and high recurrence rate attributed to its complex pathogenic mechanism. Syndecan1 (SDC1) contributes to regulating cell migration and invasion by activating epithelial-mesenchymal transition (EMT) in tumor and fibrotic disease. Herein, using western blot analysis, the authors assessed the role of SDC1 on EMT in keloid and its underlying mechanism.
View Article and Find Full Text PDFJ Clin Oncol
December 2024
Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
J Hepatocell Carcinoma
November 2024
Department of Oncology, Yanbian University Hospital, Yanji, People's Republic of China.
Background: Primary hepatic Neuroendocrine carcinoma (PHNEC) is exceptionally rare, and when it cannot be surgically removed locally, systemic combination therapy is the preferred treatment. However, current treatments have shown limited effectiveness, and more effective approach remains a matter of debate.
Case Presentation: We present a case involving a female patient diagnosed with non-surgically suitable PHNEC, confirmed through pathology.
J Med Case Rep
November 2024
Department of Laboratory Medicine, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, China.
Asian J Surg
November 2024
Department of Cardiovascular SurgeryⅡ, Yanbian University Hospital, Yanji, 133000, Jilin, China. Electronic address:
Neuropsychiatr Dis Treat
November 2024
Department of Emergency Medicine, The First Hospital of Jilin University, Changchun, Jilin, 130000, People's Republic of China.
Asian J Surg
November 2024
Department of Nuclear Medicine, Yanbian University Hospital, Yanji, 133000, Jilin, China. Electronic address:
Asian J Surg
November 2024
Department of Nuclear Medicine, Yanbian University Hospital, Yanji, 133000, Jilin, China. Electronic address:
Asian J Surg
November 2024
Department of Nuclear Medicine, Yanbian University Hospital, Yanji, 133000, Jilin, China. Electronic address:
Sci Rep
November 2024
Yanbian University Hospital, Yanji, Jilin Province, China.
Heart
November 2024
Department of Cardiology, The First Hospital of Jilin University, Changchun, Jilin, China
Cell Death Dis
November 2024
College of Pharmacy, Yanbian University Hospital, Yanbian University, Yanji, 133002, P. R. China.
Ferroptosis is a distinctive process of cellular demise that is linked to amino acid metabolism, lipid oxidation, and iron oxidation. The ferroptosis cascade genes, which are closely associated with the onset of lung diseases, are among the regulatory targets of nuclear factor erythroid 2-related factor 2 (Nrf2). Although the regulation of ferroptosis is mostly mediated by Nrf2, the precise roles and underlying regulatory mechanisms of ferroptosis and Nrf2 in lung illness remain unclear.
View Article and Find Full Text PDFLife Sci
December 2024
Department of Pathology & Cancer Research Center, Yanbian University Medical College, Yanji, China; Central Laboratory, Yanbian University Hospital & Key Laboratory of Pathobiology, Yanbian University, State Ethnic Affairs Commission, Yanji, China. Electronic address:
Cancer cells possess an extraordinary ability to dodge cell death through various pathways, granting them a form of immortality-a key obstacle in oncotherapy. Thus, it's vital to unravel the intricate mechanisms behind newly discovered types of cell death that drive tumor suppression, going beyond apoptosis alone. The emergence of PANoptosis, a form of cell death intertwining necroptosis, pyroptosis, and apoptosis, offers a fresh perspective, integrating these pathways into one cohesive process.
View Article and Find Full Text PDFMol Med Rep
January 2025
Department of Pathology, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China.
In the present study, pleckstrin homology domain‑containing family A member 4 (PLEKHA4) was identified as being upregulated in renal cell carcinoma, particularly within the kidney renal clear cell carcinoma (KIRC) subtype. The present study conducted bioinformatics analysis, Cell Counting Kit‑8 and cell migration assays, flow cytometry, western blotting and experiments with the aim of uncovering the role of PLEKHA4 in β‑catenin signaling in KIRC cells. Notably, PLEKHA4 upregulation was revealed to be associated with enhanced cell proliferation, indicating its potential role as an oncogene in KIRC.
View Article and Find Full Text PDFIran J Basic Med Sci
January 2024
Cancer Research Center, Yanbian University Medical College, Key Laboratory of Pathobiology (Yanbian University), State Ethnic Affairs Commission, Research and Innovation Group of Yanbian University, Yanji 133002, China.
Objectives: Baicalein (BAI) is one of the main ingredients of georgi. Its pharmacological effects have been widely reported in various cancers. However, the specific molecular mechanism of BAI in gastric cancer (GC) has not been defined.
View Article and Find Full Text PDFKorean J Physiol Pharmacol
November 2024
Department of Pathology, Yanbian University Hospital, Yanji 133002, Jilin, China.
Macrophages are innate immune cells connected with the development of inflammation. Retinoic acid has previously been proved to have anti-inflammatory and anti-arthritic properties. However, the exact mechanism through which retinoic acid modulates arthritis remains unclear.
View Article and Find Full Text PDFNeurobiol Stress
November 2024
Key Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, China.
There is increasing evidence that chronic stress (CS), which occurs when the body is exposed to prolonged stressors, significantly impairs learning and memory. Dopamine (DA) plays a critical role in learning and memory in the hippocampus through the activation of D1-like receptors (D1R). However, the specific roles of DA and D1R in the hippocampal dentate gyrus (DG), particularly in CS-induced changes in spatial learning and memory, are not well understood.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
November 2024
College of Pharmacy, Yanbian University Hospital, Yanbian University, Yanji, Jilin, 133000, China.
While studies have shown that Angelica gigas Nakai (A. gigas) can alleviate ulcerative colitis in mice, the therapeutic role of its main active ingredient, decursin, is uncertain. Therefore, we aimed to investigate the protective effect and mechanism of decursin against inflammatory bowel disease (IBD) in vivo using mice.
View Article and Find Full Text PDFBMC Nephrol
November 2024
Department of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, 310000, China.
Discov Oncol
November 2024
Department of Ultrasound, Yanbian University Hospital, No. 1327, Juzi Street, Yanji City, 133000, Jilin Province, China.
Objective: To prepare and characterize transferrin (Tf)-modified liposomes (Lipo) encapsulating the photosensitizing agent neoindocyanine green (IR820), and to investigate their effects on breast cancer 4T1 cells as well as in a breast cancer mouse model.
Methods: Photosensitive liposomes, IR820@Lipo and Tf-IR820@Lipo, were synthesized using thin film dispersion, with encapsulation efficiency assessed via UV detection. The physicochemical properties were analyzed using transmission electron microscopy (TEM) and particle size analysis.