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32 results match your criteria: "Yanbian University Affiliated Hospital[Affiliation]"
Exp Ther Med
December 2024
Department of Neurosurgery, Yanbian University Affiliated Hospital, Yanbian University, Yanji, Jilin 133000, P.R. China.
Stroke, including hemorrhagic stroke and ischemic stroke, is a common disease of the central nervous system. It is characterized by a high mortality and disability rate and is closely associated with atherosclerosis, hypertension hyperglycemia, atrial fibrillation and unhealthy living habits. The continuous development of surgery and medications has decreased the mortality rate of patients with stroke and has greatly improved the disease prognosis.
View Article and Find Full Text PDFInt Immunopharmacol
October 2024
Department of Functional Science, College of Medicine, Yanbian University, Yanji, Jilin, PR China. Electronic address:
Int Immunopharmacol
July 2024
Department of Functional Science, College of Medicine, Yanbian University, Yanji, Jilin, PR China. Electronic address:
An inflammatory response is one of the pathogeneses of depression. The anti-inflammatory and neuroprotective effects of auraptene have previously been confirmed. We established an inflammatory depression model by lipopolysaccharide (LPS) injection combined with unpredictable chronic mild stress (uCMS), aiming to explore the effects of auraptene on depressive-like behaviors in adult mice.
View Article and Find Full Text PDFZhongguo Dang Dai Er Ke Za Zhi
April 2024
Perinatal/Neonatal Clinic and Children's Family Clinic, Yanbian University Affiliated Hospital, Yanji, Jilin 133000, China.
Medicine is a continuously advancing science, characterized by the integration of multiple disciplines, ultimately focusing on the "human" aspect. Over the past half-century, there has been a global surge in efforts to reshape the humanistic spirit of medicine. Narrative medicine, a field that highly integrates medical professionalism with universal humanistic values, has developed rapidly in China from scratch over the past decade or so.
View Article and Find Full Text PDFEur J Pharmacol
October 2023
Department of Functional Science, College of Medicine, Yanbian University, Park Street 977, Yanji, 133002, Jilin, PR China; Experimental Teaching Center of Morphology, College of Medicine, Yanbian University, Park Street 977, Yanji, 133002, Jilin, PR China. Electronic address:
Bioactive lipid mediator N-palmitoylethanolamide (PEA) is an endocannabinoid-like molecule. Based on our previous data, this study aimed to further investigate the antidepressant property of PEA via the peroxisome proliferator-activated receptor alpha (PPARα) pathway, focusing on the intervention of PEA on hippocampal neuroplasticity. Behavioral tests were performed in rats induced by unpredictable chronic mild stress (uCMS) in the last week of the experiment, and then the brain tissue samples were retained for subsequent immunohistochemical detection and Western blot analysis.
View Article and Find Full Text PDFThe primary site of infection in COVID-19 exhibit is the respiratory system, but multiple organ systems could be affected. The virus could directly invade cardiomyocytes. Alternatively, cytokine storm could lead to myocardial injury.
View Article and Find Full Text PDFRespirology
August 2022
Department of Pulmonary and Critical Care Medicine, East Hospital, Shanghai, China.
Front Pharmacol
November 2021
Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, China.
Hepatocellular carcinoma results in a high risk of second primary malignancies and has prominent morbidity and mortality. There is a lack of effective treatment and prognosis is poor. Therefore, effective drugs need to be discovered.
View Article and Find Full Text PDFClin Infect Dis
June 2022
Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin, China.
Background: Pradefovir is a liver-targeted prodrug of adefovir, a nucleoside/nucleotide analogue with antiviral activity against hepatitis B virus (HBV) DNA polymerase. This phase 2 study compared the efficacy and safety of oral pradefovir (30, 45, 60, or 75 mg) versus tenofovir disoproxil fumarate (TDF; 300 mg) and aimed to identify the most appropriate dose of pradefovir for the forthcoming phase 3 study.
Methods: Treatment-naive and experienced (not on treatment >6 months) patients with chronic hepatitis B were eligible.
Folia Biol (Praha)
July 2021
Department of Pathology, College of Medicine, Yanbian University, Yanji, Jilin, China.
Platycodin D is an active component isolated from Chinese herb Platycodonis radix with various pharmacological activities, such as antitussive, expectorant, anti-inflammatory, and analgesic effects. Interestingly, platycodin D also exerts anticancer effects against several types of cancer. However, few studies on the anti-tumour effects of platycodin against urinary bladder cancer have been reported.
View Article and Find Full Text PDFJ Int Med Res
June 2021
Department of Radiology, Yanbian University Affiliated Hospital, Yanji, Jilin Province, China.
Primary squamous cell carcinoma of the liver is extremely rare, very difficult to diagnose, and carries an extremely poor prognosis. In this study, we discuss the imaging features of a patient with primary hepatic squamous cell carcinoma. The patient was admitted to hospital owing to discomfort in the right upper abdominal quadrant and a loss of appetite.
View Article and Find Full Text PDFEvid Based Complement Alternat Med
April 2021
Jilin Key Laboratory for Immune and Targeting Research on Common Allergic Diseases, Yanbian University, Yanji 133000, China.
Glaucocalyxin A (GLA) has various pharmacological effects like antioxidation, immune regulation, and antiatherosclerosis. Here, in this study, the effect and mechanism of GLA on mast cell degranulation were studied. The results of the anti-DNP IgE-mediated passive cutaneous anaphylaxis (PCA) showed that GLA dramatically inhibited PCA in vivo, as evidenced by reduced Evans blue extravasation and decreased ear thickness.
View Article and Find Full Text PDFLin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2021
To investigate the olfactory function of patients with obstructive sleep apnea(OSA) without any treatment, and to providereference for clinical olfactory research. One hundred and thirty-one participants underwent polysomnography(PSG) overnight, and were divided into OSA group (observation group) and non-OSA group (control group) according to the results. The two groups were examined by the Korean version of the olfactory stick test Ⅱ(Korean Bersion) of Sniffin Sticks Test (KVSS Test Ⅱ).
View Article and Find Full Text PDFAging (Albany NY)
December 2020
Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji, China.
SPOCK1 is highly expressed in many types of cancer and has been recognized as a promoter of cancer progression. Its regulatory mechanism in breast cancer (BC) remains unclear. This study aimed to explore the precise function of SPOCK1 in BC progression and to identify the mechanism by which SPOCK1 is involved in cell proliferation and epithelial-mesenchymal transition (EMT).
View Article and Find Full Text PDFPathol Res Pract
December 2020
Department of Pathology, Yanbian University College of Medicine, Yanji 133002, Jilin Province, P.R. China; Institute for Regenerative Medicine, Yanbian University College of Medicine, Yanji 133002, Jilin Province, PR China. Electronic address:
SETD8 is a lysine methyltransferase containing an SET domain and has been reported to regulate various biological processes, including carcinogenesis. However, its prognostic value and mechanisms of action in non-small cell lung cancer (NSCLC) have not been extensively studied. Here, we assessed SETD8 expression and its relationship with clinicopathological parameters, cancer stemness proteins, and cell cycle-regulating proteins in NSCLC.
View Article and Find Full Text PDFLiver Int
November 2020
Department of Hepatology, the First Hospital of Jilin University, Changchun, China.
Background & Aim: An affordable, pangenotypic regimen remains as an unmet medical need for chronic hepatitis C patients in China. This single-arm, open-label, multicenter, phase 3 trial evaluated the efficacy and safety of coblopasvir, a pangenotypic non-structural protein 5A (NS5A) inhibitor, combined with sofosbuvir for treating Chinese patients with chronic hepatitis C virus (HCV) infection.
Methods: Treatment-naïve and interferon-experienced adult patients, including those with advanced fibrosis (F3) or compensated cirrhosis (F4), were treated with a universal, combinational regimen of coblopasvir 60 mg and sofosbuvir 400 mg, once daily, for 12 weeks.
Ophthalmic Res
April 2023
Department of Ophthalmology, Second Hospital of Jilin University, Jilin University, Changchun, China.
Background: Excessive scarring of filtering blebs is the main cause of surgical failure in glaucoma. Previous studies have highlighted the role of chloride channels (ClCs) in scar formation, whereas the role of ClCs in scarring of filtering blebs has not been studied.
Objectives: The objective of this study was to investigate the effects of the chloride channel 2 (ClC-2) on scar formation of filtering blebs after glaucoma filtering surgery.
Cancer Manag Res
March 2020
Institute for Regenerative Medicine, Yanbian University College of Medicine, Yanji 133002, Jilin Province, People's Republic of China.
Purpose: The leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is a mitochondrial protein that has been associated with the occurrence and development of malignant tumors. Previous studies have shown that LETM1 expression is increased in several types of human cancer and is associated with a poor clinical outcome. However, the role of LETM1 in prostate cancer (PCa) has not yet been determined.
View Article and Find Full Text PDFLin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
February 2020
The aim of this study is to investigate the incidence of dysosmia in patients with and without nasal polyps, and the impact of dysosmia on the quality of life and mental health in patients with Sinusitis. A total of 105 randomly selected patients with Sinusitis were divided into two groups based on the results of the Sniffin's Sticks olfactory examination: The dysosmia group and the non dysosmia group, the quality of life (Qol) of olfaction quality of life scale and SCL-90 symptom checklist-90(SCL-90) were scored respectively. The incidence of olfactory disorders in chronic sinusitis patients with nasal polyps was significantly higher than those without nasal polyps(χ²=37.
View Article and Find Full Text PDFPhytomedicine
March 2020
Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Molecular Medicine Research Center, Ministry of education, College of Pharmacy, Yanbian University, Yanji 133002, Jilin Province, China. Electronic address:
Background: Aberrant activation of STAT3 is frequently encountered and promotes survival, cellular proliferation, migration, invasion and angiogenesis in tumor cell. Convallatoxin, triterpenoid ingredient, exhibits anticancer pharmacological properties.
Purpose: In this work, we investigated the anticancer potential of convallatoxin and explored whether convallatoxin mediates its effect through interference with the STAT3 activation in colorectal cancer cells.
Microb Pathog
January 2020
Eye Center, The Second Hospital of Jilin University, Changchun 130041, China. Electronic address:
As a kind of serious, potentially sight-threatening corneal infections with poor prognosis, fungal keratitis can bring a heavy economic burden to patients and seriously affect the quality of life, especially those in developing countries where fungal keratitis is more prevalent. Typical clinical features include immune rings, satellite lesions, pseudopods, hypha moss, hypopyon and endothelial plaques. The ideal therapeutic effects could not be achieved by current treatments for many reasons.
View Article and Find Full Text PDFJ Viral Hepat
January 2020
Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
A simple, pangenotypic and effective treatment regimen for patients with a broad range of chronic hepatitis C virus (HCV) infections remains an unmet medical need. We conducted a phase 2, randomized, open study involving untreated patients with chronic HCV genotypes 1, 2, 3, or 6 infections. Patients without cirrhosis were randomly assigned in a 1:2 ratio to receive capsules of the NS5A inhibitor coblopasvir at a dose of 30 or 60 mg plus tablets of the nucleotide polymerase inhibitor sofosbuvir (400 mg) once daily for 12 weeks.
View Article and Find Full Text PDFCancer Manag Res
July 2019
Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji 133002, People's Republic of China.
Abstract: Endoplasmic reticulum oxidoreductase 1-α (ERO1A) is a kind of hypoxia-induced endoplasmic reticulum oxidase that regulates translation and folding of oxidized proteins. This study aimed to explore the clinicopathological significance of ERO1A and the effect on the biological behavior of cholangiocarcinoma (CCA) cells.
Methods: Immunohistochemical staining was used to detect the expression of ERO1A, carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) in cholangiocarcinoma.
Exp Mol Pathol
August 2019
Institute for Regenerative Medicine, Yanbian University College of Medicine, Yanji, China; Department of Pathology, Yanbian University College of Medicine, Yanji, China. Electronic address:
Although tenascin-C (TNC), an extracellular matrix protein, has been shown to be widely expressed in stromal fibroblasts in various cancers, the role of its expression in esophageal squamous cell carcinoma (ESCC) cells remains unclear. Using immunohistochemistry, we investigated the expression of cancer stem-like cell (CSC) markers, epithelial-to-mesenchymal transition (EMT)-related genes, and the Akt/hypoxia-inducible factor-1α (HIF1α) signal pathway in ESCC tissue specimens from 154 patients. We further addressed the effects of TNC on the Akt/HIF1α axis and its putative association with cancer stemness in several ESCC cell lines by immunofluorescence imaging and western blot analysis.
View Article and Find Full Text PDFZhonghua Wei Zhong Bing Ji Jiu Yi Xue
August 2018
Department of Intensive Care Unit, Yanbian University Affiliated Hospital, Yanji 133000, Jilin, China (Xu HX, Lei YN, Cui QS, Jin MG); Department of Intensive Care Unit, Shuyang Hospital of Traditional Chinese Medicine, Suqian 223600, Jiangsu, China (Xie J). Corresponding author: Jin Minggen, Email:
Objective: To investigate the anti-inflammatory effect of penehyclidine hydrochloride on oleic acid-induced acute respiratory distress syndrome (ARDS) in rats.
Methods: According to randomize number table method, 30 adult male Sprague-Dawley (SD) rats were divided into control group, model group and treatment group. Catheters were placed in femoral vein in each group.