Global research trends on biomarkers for cancer immunotherapy: Visualization and bibliometric analysis.

The global burden of cancer continues to grow, posing a significant public health challenge. Although cancer immunotherapy has shown significant efficacy, the response rate is not high. Therefore, the objective of our research was to identify the latest research trends and hotspots on biomarkers from 1993 to 2023.

Functional Role of Odorant-Binding Proteins in Response to Sex Pheromone Component 8-14:Ac in (Busck).

The plum fruit moth (PFM), , and the oriental fruit moth (OFM), , are closely related fruit moth species that severely damage fruit trees in Rosaceae. Both species share common primary sex pheromone components 8-12:Ac and 8-12:Ac. The secondary sex pheromone components of PFMs consist of 8-12:OH, 8-14:Ac, and 10-14:Ac, while those of OFMs include 8-12:OH and 12:OH.

Elbow rotation affects the accuracy of rotational formulas: validation of a modified method.

Background: Supracondylar humerus fractures (SCHFs) are the most common elbow fractures in children and are typically treated with closed reduction and Kirschner pin fixation. However, varying degrees of residual rotational displacement may remain after closed reduction. Several methods exist to assess rotational displacement, but none account for the effect of elbow rotation on the results.

Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content.

The anti-PD-1 mAb may be further considered along with PGD2 or active molecules that can promote PGD2 synthesis to enhance the anti-tumor immune response.

A sensitive bromate sensor based on a gold nanoparticle-poly(diallyldimethylammonium chloride)-reduced graphene oxide nanocomposite modified glassy carbon electrode.

A nanocomposite consisting of gold nanoparticles (AuNPs), poly(diallyldimethylammonium chloride) (PDDA), and reduced graphene oxide (rGO) was fabricated by a two-step chemical reduction method. Firstly, a PDDA-rGO composite was prepared by using hydrazine hydrate as a reducing agent. Subsequently, the AuNP-PDDA-rGO composite was prepared in ethylene glycol with PDDA-rGO and HAuCl as raw materials using sodium citrate as a reduction agent.

Status quo and influencing factors of job burnout among residents in standardized training.

Background: With the continuous progress and in-depth implementation of the reform of the medical and health care system, alongside the gradual enhancement of the standardized training framework for residents, such training has become a crucial avenue for cultivating high-level clinicians and improving medical quality. However, due to various constraints and limitations in their own capabilities, residents undergoing standardized training are often susceptible to job burnout during this process. Numerous factors contribute to job burnout, which is closely associated with depression and anxiety.

Bloodstream Infection Combined with Thoracic Infection Caused by : A Case Report and Review of the Literature.

Objective: is usually found in urogenital tract infections and is associated with several extra-genitourinary infections, including septic arthritis, bacteremia, and meningitis. Here, we report a rare case of induced bloodstream infection with thoracic inflammation in a surgical patient.

Methods: A 56-year-old male who underwent surgery for multiple pelvic and rib fractures developed fever, pleural effusion, and wound exudation despite receiving prophylactic anti-infection treatment with cefotiam.

First Documented Successful Treatment of Chronic Postoperative Fungal Endophthalmitis Induced by with Fluconazole.

This report details an uncommon occurrence of chronic endophthalmitis following cataract surgery attributed to an infection by Trichosporon inkin (T. inkin). The infection was identified through MALDI-TOF mass spectrometry along with sequencing analysis.

Amelioration of Gap Junction Dysfunction in a Depression Model by Loganin: Involvement of GSK-3β/β-Catenin Signaling.

Ethnopharmacological Relevance: Comus officinalis Sieb. et Zucc has significant neuroprotective activity and has been widely studied for its potential to improve cognitive function. Our team's previous research has found that loganin isolated from Comus officinalis has an antidepressant effect.

Scaffolding and Heavy-Atom Effects of Metal Chains Enhanced Tunable Long Persistent Luminescence in Metal-Organic Frameworks.

Metal-organic frameworks (MOFs) with long persistent luminescence (LPL) have attracted extensive research attention due to their potential applications in information encryption, anticounterfeiting technology, and security logic. The strategic combinations of organic phosphor linkers and metal ions lead to tremendous frameworks, which could unveil many undiscovered properties of organics. Here, the synthesis and characterization of a three-dimensional MOF (Cd-MOF) is reported, which demonstrates enhanced blue photoluminescence and a phosphorescent lifetime of 124 ms as compared to the pristine linker (HL) under ambient conditions due to the scaffolding and heavy-atom effects of metal chains in the framework.

[Holliday junction-recognizing protein is a potential predictive and prognostic biomarker for kidney renal clear cell carcinoma].

Objectives: To investigate the role of Holliday cross-recognition protein (HJURP) in tumorigenesis, progression, and immunotherapy responses.

Methods: Bioinformatics approaches were used to analyze the expression level of in various cancers and its association with prognosis, clinical stage, and immune cell infiltration using TCGA, GTEx, SangerBox and TIMER 2.0 databases.

A review of sodium alginate-based hydrogels: Structure, mechanisms, applications, and perspectives.

With the global emphasis on green and sustainable development, sodium alginate-based hydrogels (SAHs), as a renewable and biocompatible environmental material, have garnered widespread attention for their research and application. This review summarizes the latest advancements in the study of SAHs, thoroughly discussing their structural characteristics, formation mechanisms, and current applications in various fields, as well as prospects for future development. Initially, the chemical structure of SA and the network structure of hydrogels are introduced, and the impact of factors such as molecular weight, crosslinking density, and environmental conditions on the hydrogel structure is explored.

Uncovering ZnS growth behavior and morphology control for high-performance aqueous Zn-S batteries.

Aqueous Zn-S batteries provide competitive energy density for large-scale energy storage systems. However, the cathode active material exhibits poor electrical conductivity especially at the discharged state of ZnS. Its morphology generated in cells thus directly determines the cathode electrochemical activity.

Data-Driven Machine Learning Strategy for Designing Metal-Ion-Doped γ-BiMoO Photocatalysts to Enhance Degradation Performance.

Doped semiconductors are often used to improve photocatalytic efficiency and address the challenges of easy recombination of electron-hole pairs and poor photoluminescence. However, the reproducibility and complexity of experimental studies result in time-consuming and less cost-effective studies, and it is difficult to gain insights into the intrinsic properties of doped photocatalysts to control their performance. Introducing a machine learning approach, we constructed a photocatalytic model of transition-metal- and rare earth metal-ion-doped γ-BiMoO.

3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models.

Tissue engineering and in vitro modeling of the airways and lungs in the respiratory system are of substantial research and clinical importance. In vitro airway and lung models aim to improve treatment options for airway and lung repair and advance respiratory pathophysiological research. The construction of biomimetic native airways and lungs with tissue-specific biological, mechanical, and configurable features remains challenging.

Precise application of water and fertilizer to crops: challenges and opportunities.

Precision water and fertilizer application technologies have emerged as crucial innovations in sustainable agriculture, addressing the pressing need to enhance crop yield and quality while optimizing resource use and minimizing environmental impacts. This review systematically explores the latest advancements in precision water and fertilizer application technologies. It examines the integration of advanced sensors, remote sensing, and machine learning algorithms in precision agriculture, assessing their roles in optimizing irrigation and nutrient management.

Epidemiological characteristics of eleven common respiratory viral infections in children.

Background: Lower respiratory tract infections (LRTIs) are one of the leading causes of hospital admissions among children. In this study, we aimed to describe the epidemiological characteristics of viral pathogens associated with LRTIs in hospitalized children in Yan'an; this has yet to be reported in the literature and may guide public health interventions and resource allocation in this region.

Methods: Between June 2021 and May 2023, we conducted a retrospective analysis of the results of viral detection using oral pharyngeal swabs from 4565 children with LRTIs in the Inpatient Department of Yan'an University Affiliated Hospital.

Zn and Cl Coregulated MXene Catalyst Enhances Li-CO Battery Reversibility.

MXenes are promising cathodes for Li-CO batteries owing to their high electrical conductivity and efficient CO activation function. However, the effects of adsorption and electronic structures of MXene on the full life cycle of Li-CO batteries have been rarely investigated. Here, we employ a coregulation approach to enhance the adsorption-decomposition of lithium carbonate (LiCO) by introducing Zn and Cl surface groups onto the TiC MXene (Zn-TiCCl) catalyst.

U-Shaped Relationship Between MSpO Levels and the Incidence of Frailty in Elderly OSA Patients: Findings from a Multicenter Cohort Study.

Background: Previous studies have demonstrated a significant correlation between obstructive sleep apnea (OSA) and frailty. However, the association of mean pulse oxygen saturation (MSpO) with frailty among OSA patients remains unconfirmed. This study aimed to explore this potential association using data from a multicenter, prospective cohort.

Genome-Wide Analysis of BURP Domain-Containing Gene Family in and Functional Analysis of Under Drought and Salt Stresses.

The BURP domain-containing () genes belong to plant-specific families and are known as essential for various biological processes in plants. However, knowledge of the functions of genes in tomato () is lacking. In our study, bioinformatics analysis was performed for the gene family, including phylogeny, chromosomal localization, gene structure, -acting elements and expression.

Lateral malleolus-first fixation improves short-term recovery in patients with trimalleolar fractures.

Objective: To evaluate the impact of different surgical fixation sequences on ankle joint stability and functional recovery in patients with trimalleolar fractures.

Methods: A retrospective analysis was conducted on the medical records of 144 patients with trimalleolar fractures treated at Xi'an International Medical Center Hospital. Among these, 78 patients underwent the fixation sequence of lateral malleolus-posterior malleolus-medial malleolus (Group A), while 66 patients underwent the sequence of posterior malleolus-lateral malleolus-medial malleolus (Group B).

Exosomal miRNA-let-7i-5p from bone marrow mesenchymal stem cells protects against myocardial infarction by inhibiting myocardial apoptosis.

Objectives: To elucidate the regulatory effect of exosomes secreted by bone marrow mesenchymal stem cells (BMSCs-exosomes) on cardiomyocyte apoptosis through miRNA-let-7i-5p in myocardial infarction.

Methods: BMSCs-exosomes were extracted, and their morphology and size distribution were analyzed using transmission electron microscope. Expression of exosome surface markers was determined by western blot.

The role of DUOXA2 in the clinical diagnosis of paediatric congenital hypothyroidism.

: Congenital hypothyroidism (CH) is a common metabolic disorder in children that can impact growth and neurodevelopment, particularly during infancy and early childhood. DUOXA2, a DUOX maturation factor, plays a crucial role in the maturation and activation of dual oxidase DUOX2 (a member of the NADPH oxidase family). DUOX2 can correctly migrate to the plasma membrane from the endoplasmic reticulum (ER) with the help of DUOXA2, and the two proteins together form a stable complex that promotes hydrogen peroxide (H2O2) generation in the synthesis of thyroid hormones.

Erratum: Inhibition of STAT3 signaling as critical molecular event in HUC-MSCs suppressed Glioblastoma Cells: Erratum.

[This corrects the article DOI: 10.7150/jca.77905.