2 results match your criteria: "Yamaguchi University Graduate School of Medicine 1-1-1 Minamikogushi[Affiliation]"

Dantrolene is a ryanodine receptor blocker that is used clinically for treatment of malignant hyperthermia. This study was conducted using murine aortic vascular smooth muscle cells (MOVAS) and a mouse arterial injury model to investigate the inhibitory effect of dantrolene on smooth muscle cell proliferation and migration. We investigated whether dantrolene suppressed platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and migration in vitro.

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Article Synopsis
  • The study investigated how intrapulmonary clots (IPCs) influence lung perfused blood volume (LPBV) improvement after anticoagulation therapy using advanced CT imaging in patients with venous thromboembolism.
  • A total of 81 patients were analyzed, with significant findings indicating that those with IPCs showed higher initial D-dimer levels and V5 values, but these differences diminished with treatment.
  • The results highlighted that increased overall lung perfusion (V120) and decreased low perfusion volume (V5) significantly contribute to the improvement in the %V5 values post-treatment.
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